ID   FUCR_ECOLI              Reviewed;         243 AA.
AC   P0ACK8; P11554; Q2MA29;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=L-fucose operon activator;
GN   Name=fucR; OrderedLocusNames=b2805, JW2776;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   PubMed=2664711; DOI=10.1093/nar/17.12.4883;
RA   Lu Z., Lin E.C.C.;
RT   "The nucleotide sequence of Escherichia coli genes for L-fucose
RT   dissimilation.";
RL   Nucleic Acids Res. 17:4883-4884(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: Transcriptional activator of the fuc operon.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X15025; CAA33130.1; -; Genomic_DNA.
DR   EMBL; U29581; AAB40455.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC75847.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76877.1; -; Genomic_DNA.
DR   PIR; JS0188; RGECFO.
DR   RefSeq; NP_417285.1; NC_000913.3.
DR   RefSeq; WP_000642344.1; NZ_STEB01000030.1.
DR   AlphaFoldDB; P0ACK8; -.
DR   SMR; P0ACK8; -.
DR   BioGRID; 4263538; 13.
DR   BioGRID; 851244; 1.
DR   IntAct; P0ACK8; 5.
DR   STRING; 511145.b2805; -.
DR   jPOST; P0ACK8; -.
DR   PaxDb; P0ACK8; -.
DR   PRIDE; P0ACK8; -.
DR   EnsemblBacteria; AAC75847; AAC75847; b2805.
DR   EnsemblBacteria; BAE76877; BAE76877; BAE76877.
DR   GeneID; 66673328; -.
DR   GeneID; 946905; -.
DR   KEGG; ecj:JW2776; -.
DR   KEGG; eco:b2805; -.
DR   PATRIC; fig|1411691.4.peg.3928; -.
DR   EchoBASE; EB0349; -.
DR   eggNOG; COG1349; Bacteria.
DR   HOGENOM; CLU_060699_1_2_6; -.
DR   OMA; YKHSMVA; -.
DR   PhylomeDB; P0ACK8; -.
DR   BioCyc; EcoCyc:PD00444; -.
DR   PRO; PR:P0ACK8; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0098531; F:ligand-activated transcription factor activity; IMP:EcoCyc.
DR   GO; GO:0006004; P:fucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0043468; P:regulation of fucose catabolic process; IMP:EcoCyc.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR014036; DeoR_C.
DR   InterPro; IPR001034; DeoR_HTH.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR018356; Tscrpt_reg_HTH_DeoR_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00455; DeoRC; 1.
DR   Pfam; PF08220; HTH_DeoR; 1.
DR   PRINTS; PR00037; HTHLACR.
DR   SMART; SM00420; HTH_DEOR; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00894; HTH_DEOR_1; 1.
DR   PROSITE; PS51000; HTH_DEOR_2; 1.
PE   4: Predicted;
KW   Activator; Carbohydrate metabolism; DNA-binding; Fucose metabolism;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..243
FT                   /note="L-fucose operon activator"
FT                   /id="PRO_0000050247"
FT   DOMAIN          1..57
FT                   /note="HTH deoR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
FT   DNA_BIND        19..38
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
SQ   SEQUENCE   243 AA;  27362 MW;  3DFBBD33E7E64296 CRC64;
     MKAARQQAIV DLLLNHTSLT TEALSEQLKV SKETIRRDLN ELQTQGKILR NHGRAKYIHR
     QNQDSGDPFH IRLKSHYAHK ADIAREALAW IEEGMVIALD ASSTCWYLAR QLPDINIQVF
     TNSHPICHEL GKRERIQLIS SGGTLERKYG CYVNPSLISQ LKSLEIDLFI FSCEGIDSSG
     ALWDSNAINA DYKSMLLKRA AQSLLLIDKS KFNRSGEARI GHLDEVTHII SDERQVATSL
     VTA