ID   FUCO_DICDI              Reviewed;         461 AA.
AC   P10901; Q554R0;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 132.
DE   RecName: Full=Alpha-L-fucosidase;
DE            EC=3.2.1.51;
DE   AltName: Full=Alpha-L-fucoside fucohydrolase;
DE   Flags: Precursor;
GN   Name=alfA; ORFNames=DDB_G0274391;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AX2, and AX3;
RX   PubMed=2540036; DOI=10.1016/0014-5793(89)80280-7;
RA   Mueller-Taubenberger A., Westphal M., Noegel A., Gerisch G.;
RT   "A developmentally regulated gene product from Dictyostelium discoideum
RT   shows high homology to human alpha-L-fucosidase.";
RL   FEBS Lett. 246:185-192(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-
CC       1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the
CC       carbohydrate moieties of glycoproteins.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an alpha-L-fucoside + H2O = an alcohol + L-fucose;
CC         Xref=Rhea:RHEA:12288, ChEBI:CHEBI:2181, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:28349, ChEBI:CHEBI:30879; EC=3.2.1.51;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10054};
CC   -!- MISCELLANEOUS: The maximum expression of alpha-L-fucosidase occurs
CC       during aggregation stage of dictyostelium discoideum.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 29 family. {ECO:0000305}.
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DR   EMBL; Y07497; CAA68800.1; -; Genomic_DNA.
DR   EMBL; AAFI02000012; EAL70088.1; -; Genomic_DNA.
DR   PIR; A30364; A30364.
DR   RefSeq; XP_644263.1; XM_639171.1.
DR   AlphaFoldDB; P10901; -.
DR   SMR; P10901; -.
DR   STRING; 44689.DDB0185016; -.
DR   CAZy; GH29; Glycoside Hydrolase Family 29.
DR   PaxDb; P10901; -.
DR   PRIDE; P10901; -.
DR   EnsemblProtists; EAL70088; EAL70088; DDB_G0274391.
DR   GeneID; 8619691; -.
DR   KEGG; ddi:DDB_G0274391; -.
DR   dictyBase; DDB_G0274391; alfA.
DR   eggNOG; KOG3340; Eukaryota.
DR   HOGENOM; CLU_002934_1_1_1; -.
DR   InParanoid; P10901; -.
DR   OMA; LPEHKWE; -.
DR   PhylomeDB; P10901; -.
DR   BRENDA; 3.2.1.51; 1939.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   Reactome; R-DDI-975578; Reactions specific to the complex N-glycan synthesis pathway.
DR   PRO; PR:P10901; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005576; C:extracellular region; IDA:dictyBase.
DR   GO; GO:0005764; C:lysosome; IDA:dictyBase.
DR   GO; GO:0033938; F:1,6-alpha-L-fucosidase activity; IDA:dictyBase.
DR   GO; GO:0004560; F:alpha-L-fucosidase activity; IDA:dictyBase.
DR   GO; GO:0006004; P:fucose metabolic process; IDA:dictyBase.
DR   GO; GO:0016139; P:glycoside catabolic process; IBA:GO_Central.
DR   GO; GO:0051591; P:response to cAMP; IDA:dictyBase.
DR   Gene3D; 2.60.40.1180; -; 1.
DR   InterPro; IPR016286; FUC_metazoa-typ.
DR   InterPro; IPR031919; Fucosidase_C.
DR   InterPro; IPR000933; Glyco_hydro_29.
DR   InterPro; IPR018526; Glyco_hydro_29_CS.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR10030; PTHR10030; 1.
DR   Pfam; PF01120; Alpha_L_fucos; 1.
DR   Pfam; PF16757; Fucosidase_C; 1.
DR   PIRSF; PIRSF001092; Alpha-L-fucosidase; 1.
DR   PRINTS; PR00741; GLHYDRLASE29.
DR   SMART; SM00812; Alpha_L_fucos; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS00385; ALPHA_L_FUCOSIDASE; 1.
PE   3: Inferred from homology;
KW   Glycosidase; Hydrolase; Reference proteome; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..461
FT                   /note="Alpha-L-fucosidase"
FT                   /id="PRO_0000010317"
FT   SITE            288
FT                   /note="May be important for catalysis"
SQ   SEQUENCE   461 AA;  52647 MW;  CB33D0771FF4B516 CRC64;
     MKMIIIFFIL LILNLIKSQQ YGPTWDQINS RPLPGWYDDV KFGIFIHFGI YSVPAFANGG
     YAEWYWWTLK NPSSDGGATQ RYHEKEFGAN FTYQDFVSRF DCRLFDANEW ASIIEKSGAK
     YVVLTSKHHE GYTLWNSEQS WNWNSVETGP GIDIVGELTK SVKNMGLHMG LYHSLFEWFN
     PLYLADAETG KNPTTQVYVD EILMKQLKDI VTTYEPELIW ADGDWMQLSN YWKSTEFLSW
     LYTNSSVKDT VIVNDRWGSE CRDKNGGFYT GADHFNPYKL QSHKWENCAT IGYSYGYDEY
     EQATDYQNAT ELIIDLVTTV ACGGNFLLDV GPDAQGTIPN NMVDRLLEIG NWLSINSESI
     YGSSPWRVQN MTFNIWYTTN TTNGNVYAFV FELPDDGVLI LSDPIGNNKT EATLLGLKGE
     KGVEVSLPIE STKPGITLNI PMVAPQDYPP YVYVFRLTDV E