FTSH1_ORYSJ
ID FTSH1_ORYSJ Reviewed; 686 AA.
AC Q5Z974; A3BFJ7; B7EAD1; Q0D9D4;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=ATP-dependent zinc metalloprotease FTSH 1, chloroplastic;
DE Short=OsFTSH1;
DE EC=3.4.24.-;
DE Flags: Precursor;
GN Name=FTSH1; OrderedLocusNames=Os06g0725900, LOC_Os06g51029;
GN ORFNames=OsJ_021819, P0548E04.20;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16040665; DOI=10.1104/pp.105.061234;
RA Yu F., Park S., Rodermel S.R.;
RT "Functional redundancy of AtFtsH metalloproteases in thylakoid membrane
RT complexes.";
RL Plant Physiol. 138:1957-1966(2005).
CC -!- FUNCTION: Probable ATP-dependent zinc metallopeptidase. {ECO:0000250}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane
CC {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Stromal side
CC {ECO:0000250}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the AAA ATPase
CC family. {ECO:0000305}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC family. {ECO:0000305}.
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DR EMBL; AP003685; BAD61706.1; -; Genomic_DNA.
DR EMBL; AP008212; BAF20539.1; -; Genomic_DNA.
DR EMBL; AP014962; BAS99592.1; -; Genomic_DNA.
DR EMBL; CM000143; EAZ38336.1; -; Genomic_DNA.
DR EMBL; AK065019; BAG89328.1; -; mRNA.
DR RefSeq; XP_015643811.1; XM_015788325.1.
DR AlphaFoldDB; Q5Z974; -.
DR SMR; Q5Z974; -.
DR BioGRID; 811150; 1.
DR STRING; 4530.OS06T0725900-01; -.
DR MEROPS; M41.020; -.
DR PaxDb; Q5Z974; -.
DR PRIDE; Q5Z974; -.
DR EnsemblPlants; Os06t0725900-01; Os06t0725900-01; Os06g0725900.
DR GeneID; 4342113; -.
DR Gramene; Os06t0725900-01; Os06t0725900-01; Os06g0725900.
DR KEGG; osa:4342113; -.
DR eggNOG; KOG0731; Eukaryota.
DR HOGENOM; CLU_000688_16_2_1; -.
DR InParanoid; Q5Z974; -.
DR OMA; QYGMTER; -.
DR OrthoDB; 217929at2759; -.
DR Proteomes; UP000000763; Chromosome 6.
DR Proteomes; UP000007752; Chromosome 6.
DR Proteomes; UP000059680; Chromosome 6.
DR ExpressionAtlas; Q5Z974; baseline and differential.
DR Genevisible; Q5Z974; OS.
DR GO; GO:0009534; C:chloroplast thylakoid; IBA:GO_Central.
DR GO; GO:0009535; C:chloroplast thylakoid membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR Gene3D; 1.20.58.760; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01458; FtsH; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR005936; FtsH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000642; Peptidase_M41.
DR InterPro; IPR037219; Peptidase_M41-like.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF01434; Peptidase_M41; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF140990; SSF140990; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR01241; FtsH_fam; 1.
DR PROSITE; PS00674; AAA; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Cell cycle; Cell division; Chloroplast; Hydrolase; Membrane;
KW Metal-binding; Metalloprotease; Nucleotide-binding; Plastid; Protease;
KW Reference proteome; Thylakoid; Transit peptide; Transmembrane;
KW Transmembrane helix; Zinc.
FT TRANSIT 1..16
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT TRANSIT 17..?
FT /note="Thylakoid"
FT /evidence="ECO:0000255"
FT CHAIN ?..686
FT /note="ATP-dependent zinc metalloprotease FTSH 1,
FT chloroplastic"
FT /id="PRO_0000247472"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ACT_SITE 495
FT /evidence="ECO:0000250"
FT BINDING 272..279
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 494
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 498
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 575
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT CONFLICT 167
FT /note="A -> P (in Ref. 4; EAZ38336)"
FT /evidence="ECO:0000305"
FT CONFLICT 200
FT /note="G -> A (in Ref. 4; EAZ38336)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 686 AA; 72703 MW; AAE12F9DCAA85FB1 CRC64;
MAPPCSISSA SHLLITASLP KPSLRPPRLP HPKPLPAALL ALAAAAPTLP ALADVPAPPP
SPTQDVQVLE APSPAANPFS NALLTAPKPT SSAAADLPEG AQWRYSEFLS AVKKGKVERV
RFSKDGGLLQ LTAIDGRRAT VVVPNDPDLI DILATNGVDI SVAEGDAAGP GGFLAFVGNL
LFPFLAFAGL FFLFRRAQGG PGAGPGGLGG PMDFGRSKSK FQEVPETGVT FVDVAGADQA
KLELQEVVDF LKNPDKYTAL GAKIPKGCLL VGPPGTGKTL LARAVAGEAG VPFFSCAASE
FVELFVGVGA SRVRDLFEKA KAKAPCIVFI DEIDAVGRQR GAGLGGGNDE REQTINQLLT
EMDGFAGNSG VIVLAATNRP DVLDAALLRP GRFDRQVTVD RPDVAGRVKI LEVHSRGKAL
AKDVDFEKIA RRTPGFTGAD LQNLMNEAAI LAARRDLKEI SKDEISDALE RIIAGPEKKN
AVVSEEKRRL VAYHEAGHAL VGALMPEYDP VAKISIIPRG QAGGLTFFAP SEERLESGLY
SRSYLENQMA VALGGRVAEE VIFGQENVTT GASNDFMQVS RVARQMVERF GFSKKIGQVA
IGGPGGNPFL GQQMSSQKDY SMATADVVDA EVRELVEKAY SRATQIITTH IDILHKLAQL
LMEKETVDGE EFMSLFIDGQ AELFVA
