FTN_DROME
ID FTN_DROME Reviewed; 182 AA.
AC P35554; Q9VW65;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Flightin;
DE AltName: Full=Muscle protein 27;
GN Name=fln; Synonyms=FTN, mp27; ORFNames=CG7445;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Flight muscle;
RX PubMed=8486738; DOI=10.1083/jcb.121.3.587;
RA Vigoreaux J.O., Saide J.D., Valgeirsdottir K., Pardue M.L.;
RT "Flightin, a novel myofibrillar protein of Drosophila stretch-activated
RT muscles.";
RL J. Cell Biol. 121:587-598(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Ovary;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Possibly involved in the regulation of flight muscles
CC contraction, possibly by modulating actin-myosin interaction.
CC -!- TISSUE SPECIFICITY: Found only in indirect flight muscles (IFM).
CC -!- DEVELOPMENTAL STAGE: Expressed in late pupal and adult stages.
CC -!- PTM: Several forms of flightin are thought to be produced through post-
CC translational modifications, possibly by phosphorylation.
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DR EMBL; Z18858; CAA79309.1; -; mRNA.
DR EMBL; AE014296; AAF49084.1; -; Genomic_DNA.
DR EMBL; AY060802; AAL28350.1; -; mRNA.
DR PIR; A46436; A46436.
DR RefSeq; NP_001262084.1; NM_001275155.1.
DR RefSeq; NP_524174.1; NM_079450.4.
DR AlphaFoldDB; P35554; -.
DR BioGRID; 65452; 19.
DR IntAct; P35554; 9.
DR STRING; 7227.FBpp0074679; -.
DR iPTMnet; P35554; -.
DR PaxDb; P35554; -.
DR DNASU; 40185; -.
DR EnsemblMetazoa; FBtr0074910; FBpp0074679; FBgn0005633.
DR EnsemblMetazoa; FBtr0332723; FBpp0304969; FBgn0005633.
DR GeneID; 40185; -.
DR KEGG; dme:Dmel_CG7445; -.
DR UCSC; CG7445-RA; d. melanogaster.
DR CTD; 40185; -.
DR FlyBase; FBgn0005633; fln.
DR VEuPathDB; VectorBase:FBgn0005633; -.
DR eggNOG; ENOG502S9XB; Eukaryota.
DR HOGENOM; CLU_120629_0_0_1; -.
DR InParanoid; P35554; -.
DR OMA; YHTRAYY; -.
DR OrthoDB; 1632810at2759; -.
DR PhylomeDB; P35554; -.
DR SignaLink; P35554; -.
DR BioGRID-ORCS; 40185; 0 hits in 1 CRISPR screen.
DR ChiTaRS; cher; fly.
DR GenomeRNAi; 40185; -.
DR PRO; PR:P35554; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0005633; Expressed in second segment of antenna (Drosophila) and 15 other tissues.
DR ExpressionAtlas; P35554; baseline and differential.
DR Genevisible; P35554; DM.
DR GO; GO:0031672; C:A band; IDA:FlyBase.
DR GO; GO:0005863; C:striated muscle myosin thick filament; IDA:FlyBase.
DR GO; GO:0008307; F:structural constituent of muscle; IMP:FlyBase.
DR GO; GO:0097493; F:structural molecule activity conferring elasticity; IMP:FlyBase.
DR GO; GO:0007527; P:adult somatic muscle development; IMP:FlyBase.
DR GO; GO:0014703; P:oscillatory muscle contraction; IMP:FlyBase.
DR GO; GO:0045214; P:sarcomere organization; IMP:FlyBase.
DR GO; GO:0030241; P:skeletal muscle myosin thick filament assembly; IMP:FlyBase.
DR GO; GO:0071688; P:striated muscle myosin thick filament assembly; IDA:FlyBase.
PE 2: Evidence at transcript level;
KW Muscle protein; Phosphoprotein; Reference proteome.
FT CHAIN 1..182
FT /note="Flightin"
FT /id="PRO_0000087363"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..76
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 182 AA; 20656 MW; 4855356B0FD24F1E CRC64;
MADEEDPWGF DDGGEEEKAA STQAGTPAPP SKAPSVASDH KADSVVAGTP ANEEAAPEEV
EEIKAPPPPP EDDGYRKPVQ LYRHWVRPKF LQYKYMYNYR TNYYDDVIDY IDKKQTGVAR
EIPRPQTWAE RVLRTRNISG SDIDSYAPAK RDKQLIQTLA ASIRTYNYHT KAYINQRYAS
VL
