ID   AKIR1_XENTR             Reviewed;         186 AA.
AC   Q5BL57; Q28F20;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Akirin-1 {ECO:0000250|UniProtKB:Q9H9L7};
GN   Name=akirin1 {ECO:0000250|UniProtKB:Q9H9L7}; ORFNames=TGas103l22.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tail bud;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Molecular adapter that acts as a bridge between proteins, and
CC       which is involved skeletal muscle development. Functions as signal
CC       transducer for MSTN during skeletal muscle regeneration and myogenesis.
CC       {ECO:0000250|UniProtKB:Q99LF1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H9L7}.
CC   -!- SIMILARITY: Belongs to the akirin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR762217; CAJ81547.1; -; mRNA.
DR   EMBL; BC090594; AAH90594.1; -; mRNA.
DR   RefSeq; NP_001016080.1; NM_001016080.2.
DR   AlphaFoldDB; Q5BL57; -.
DR   SMR; Q5BL57; -.
DR   STRING; 8364.ENSXETP00000058585; -.
DR   PaxDb; Q5BL57; -.
DR   DNASU; 548834; -.
DR   Ensembl; ENSXETT00000065830; ENSXETP00000058585; ENSXETG00000005271.
DR   GeneID; 548834; -.
DR   KEGG; xtr:548834; -.
DR   CTD; 79647; -.
DR   Xenbase; XB-GENE-5820002; akirin1.
DR   eggNOG; KOG4330; Eukaryota.
DR   HOGENOM; CLU_119227_0_0_1; -.
DR   InParanoid; Q5BL57; -.
DR   OMA; TSESHPH; -.
DR   OrthoDB; 1420469at2759; -.
DR   TreeFam; TF317123; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000005271; Expressed in 4-cell stage embryo and 13 other tissues.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0014839; P:myoblast migration involved in skeletal muscle regeneration; IBA:GO_Central.
DR   GO; GO:1902723; P:negative regulation of skeletal muscle satellite cell proliferation; IBA:GO_Central.
DR   GO; GO:0010592; P:positive regulation of lamellipodium assembly; IBA:GO_Central.
DR   GO; GO:0010759; P:positive regulation of macrophage chemotaxis; IBA:GO_Central.
DR   GO; GO:0045663; P:positive regulation of myoblast differentiation; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   InterPro; IPR024132; Akirin.
DR   PANTHER; PTHR13293; PTHR13293; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..186
FT                   /note="Akirin-1"
FT                   /id="PRO_0000274322"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           22..27
FT                   /note="Nuclear localization signal"
FT   MOTIF           183..186
FT                   /note="SYVS motif"
FT                   /evidence="ECO:0000250|UniProtKB:Q53H80"
FT   COMPBIAS        43..59
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        57
FT                   /note="P -> L (in Ref. 1; CAJ81547)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   186 AA;  21111 MW;  6D476EB36C87F28C CRC64;
     MACGATLKRS MEFEALMSPQ SPKRRRCAPL PGSPATPSPQ RCGIRPEMQQ GQQQPLPQLG
     GDRRLTPEQI LQNIKQEYTR YQRRRQLEGA FNQSEAGVSN EVQASCSSLT APSSPGSLVK
     KDQPTFSLRQ VGILCERLLK DHEDKIREEY EQILNIKLAE QYESFVKFTH DQIMRRYGAR
     PASYVS