FIMB_ECOLI
ID FIMB_ECOLI Reviewed; 200 AA.
AC P0ADH5; P04742; Q2M601; Q47219;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Type 1 fimbriae regulatory protein FimB;
GN Name=fimB; OrderedLocusNames=b4312, JW4275;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2874022; DOI=10.1002/j.1460-2075.1986.tb04372.x;
RA Klemm P.;
RT "Two regulatory fim genes, fimB and fimE, control the phase variation of
RT type 1 fimbriae in Escherichia coli.";
RL EMBO J. 5:1389-1393(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-70.
RC STRAIN=ATCC 700336 / J96;
RX PubMed=8121417; DOI=10.1007/bf00285286;
RA Schwan W.R., Seifert H.S., Duncan J.L.;
RT "Analysis of the fimB promoter region involved in type 1 pilus phase
RT variation in Escherichia coli.";
RL Mol. Gen. Genet. 242:623-630(1994).
CC -!- FUNCTION: FimB is one of the 2 regulatory proteins which control the
CC phase variation of type 1 fimbriae in E.coli. These proteins mediate
CC the periodic inversion of a 300bp DNA segment that harbors the promoter
CC for the fimbrial structural gene, FimA. FimB switches FimA on.
CC -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
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DR EMBL; X03923; CAA27560.1; -; Genomic_DNA.
DR EMBL; U14003; AAA97208.1; -; Genomic_DNA.
DR EMBL; U00096; AAC77268.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE78305.1; -; Genomic_DNA.
DR EMBL; L07756; AAA23779.1; -; Genomic_DNA.
DR PIR; S56537; RGECFF.
DR RefSeq; NP_418732.1; NC_000913.3.
DR RefSeq; WP_000790583.1; NZ_STEB01000025.1.
DR AlphaFoldDB; P0ADH5; -.
DR SMR; P0ADH5; -.
DR BioGRID; 4259374; 158.
DR DIP; DIP-47842N; -.
DR IntAct; P0ADH5; 23.
DR STRING; 511145.b4312; -.
DR PaxDb; P0ADH5; -.
DR PRIDE; P0ADH5; -.
DR EnsemblBacteria; AAC77268; AAC77268; b4312.
DR EnsemblBacteria; BAE78305; BAE78305; BAE78305.
DR GeneID; 66671805; -.
DR GeneID; 948832; -.
DR KEGG; ecj:JW4275; -.
DR KEGG; eco:b4312; -.
DR PATRIC; fig|1411691.4.peg.2380; -.
DR EchoBASE; EB0305; -.
DR eggNOG; COG0582; Bacteria.
DR HOGENOM; CLU_027562_39_0_6; -.
DR InParanoid; P0ADH5; -.
DR OMA; KRWLAIR; -.
DR PhylomeDB; P0ADH5; -.
DR BioCyc; EcoCyc:EG10309-MON; -.
DR PRO; PR:P0ADH5; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEP:EcoliWiki.
DR GO; GO:0015074; P:DNA integration; IMP:EcoCyc.
DR GO; GO:0006310; P:DNA recombination; IMP:EcoCyc.
DR Gene3D; 1.10.443.10; -; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013762; Integrase-like_cat_sf.
DR InterPro; IPR002104; Integrase_catalytic.
DR Pfam; PF00589; Phage_integrase; 1.
DR SUPFAM; SSF56349; SSF56349; 1.
DR PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE 3: Inferred from homology;
KW DNA integration; DNA recombination; Fimbrium biogenesis;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..200
FT /note="Type 1 fimbriae regulatory protein FimB"
FT /id="PRO_0000197539"
FT DOMAIN 8..189
FT /note="Tyr recombinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 47
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 72
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 141
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 144
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 167
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 176
FT /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT CONFLICT 13
FT /note="L -> V (in Ref. 5; AAA23779)"
FT /evidence="ECO:0000305"
FT CONFLICT 32
FT /note="A -> G (in Ref. 5; AAA23779)"
FT /evidence="ECO:0000305"
FT CONFLICT 85
FT /note="E -> D (in Ref. 1; CAA27560)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 200 AA; 22993 MW; 36BFC656C68837C7 CRC64;
MKNKADNKKR NFLTHSEIES LLKAANTGPH AARNYCLTLL CFIHGFRASE ICRLRISDID
LKAKCIYIHR LKKGFSTTHP LLNKEVQALK NWLSIRTSYP HAESEWVFLS RKGNPLSRQQ
FYHIISTSGG NAGLSLEIHP HMLRHSCGFA LANMGIDTRL IQDYLGHRNI RHTVWYTASN
AGRFYGIWDR ARGRQRHAVL
