FGF16_RAT
ID FGF16_RAT Reviewed; 207 AA.
AC O54769;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Fibroblast growth factor 16;
DE Short=FGF-16;
GN Name=Fgf16;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL
RP STAGE, AND TISSUE SPECIFICITY.
RC STRAIN=Wistar; TISSUE=Heart;
RX PubMed=9473496; DOI=10.1006/bbrc.1998.8073;
RA Miyake A., Konishi M., Martin F.H., Hernday N.A., Ozaki K., Yamamoto S.,
RA Mikami T., Arakawa T., Itoh N.;
RT "Structure and expression of a novel member, FGF-16, on the fibroblast
RT growth factor family.";
RL Biochem. Biophys. Res. Commun. 243:148-152(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays an important role in the regulation of embryonic
CC development, cell proliferation and cell differentiation, and is
CC required for normal cardiomyocyte proliferation and heart development.
CC {ECO:0000250|UniProtKB:O43320, ECO:0000269|PubMed:9473496}.
CC -!- SUBUNIT: Interacts with FGFR1 and FGFR2.
CC {ECO:0000250|UniProtKB:O43320}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9473496}.
CC -!- TISSUE SPECIFICITY: In adult, predominantly expressed in heart, in the
CC cardiac myocytes. Not detected in brain, lung, liver, kidney and white
CC adipose tissue. In embryos, predominantly expressed in the brown
CC adipose tissue. {ECO:0000269|PubMed:9473496}.
CC -!- DEVELOPMENTAL STAGE: Expression in brown adipose tissue decreased
CC greatly after birth. {ECO:0000269|PubMed:9473496}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; AB002561; BAA24947.1; -; mRNA.
DR EMBL; BC085738; AAH85738.1; -; mRNA.
DR PIR; JC5940; JC5940.
DR RefSeq; NP_068639.1; NM_021867.3.
DR AlphaFoldDB; O54769; -.
DR SMR; O54769; -.
DR DIP; DIP-6040N; -.
DR STRING; 10116.ENSRNOP00000003463; -.
DR GlyGen; O54769; 1 site.
DR PaxDb; O54769; -.
DR Ensembl; ENSRNOT00000090665; ENSRNOP00000071308; ENSRNOG00000061530.
DR GeneID; 60464; -.
DR KEGG; rno:60464; -.
DR UCSC; RGD:71052; rat.
DR CTD; 8823; -.
DR RGD; 71052; Fgf16.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000160087; -.
DR HOGENOM; CLU_081609_0_0_1; -.
DR InParanoid; O54769; -.
DR OMA; NRTKKHQ; -.
DR OrthoDB; 1097566at2759; -.
DR PhylomeDB; O54769; -.
DR TreeFam; TF317805; -.
DR Reactome; R-RNO-109704; PI3K Cascade.
DR Reactome; R-RNO-1257604; PIP3 activates AKT signaling.
DR Reactome; R-RNO-190322; FGFR4 ligand binding and activation.
DR Reactome; R-RNO-190372; FGFR3c ligand binding and activation.
DR Reactome; R-RNO-190375; FGFR2c ligand binding and activation.
DR Reactome; R-RNO-5654221; Phospholipase C-mediated cascade, FGFR2.
DR Reactome; R-RNO-5654227; Phospholipase C-mediated cascade, FGFR3.
DR Reactome; R-RNO-5654228; Phospholipase C-mediated cascade, FGFR4.
DR Reactome; R-RNO-5654695; PI-3K cascade:FGFR2.
DR Reactome; R-RNO-5654699; SHC-mediated cascade:FGFR2.
DR Reactome; R-RNO-5654700; FRS-mediated FGFR2 signaling.
DR Reactome; R-RNO-5654704; SHC-mediated cascade:FGFR3.
DR Reactome; R-RNO-5654706; FRS-mediated FGFR3 signaling.
DR Reactome; R-RNO-5654710; PI-3K cascade:FGFR3.
DR Reactome; R-RNO-5654712; FRS-mediated FGFR4 signaling.
DR Reactome; R-RNO-5654719; SHC-mediated cascade:FGFR4.
DR Reactome; R-RNO-5654720; PI-3K cascade:FGFR4.
DR Reactome; R-RNO-5654727; Negative regulation of FGFR2 signaling.
DR Reactome; R-RNO-5654732; Negative regulation of FGFR3 signaling.
DR Reactome; R-RNO-5654733; Negative regulation of FGFR4 signaling.
DR Reactome; R-RNO-5673001; RAF/MAP kinase cascade.
DR Reactome; R-RNO-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR PRO; PR:O54769; -.
DR Proteomes; UP000002494; Chromosome X.
DR Bgee; ENSRNOG00000061530; Expressed in heart and 9 other tissues.
DR Genevisible; O54769; RN.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IGI:MGI.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IGI:MGI.
DR GO; GO:0070349; P:positive regulation of brown fat cell proliferation; IGI:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:2000546; P:positive regulation of endothelial cell chemotaxis to fibroblast growth factor; ISO:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028285; FGF16.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF27; PTHR11486:SF27; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Growth factor; Phosphoprotein; Reference proteome; Secreted.
FT CHAIN 1..207
FT /note="Fibroblast growth factor 16"
FT /id="PRO_0000147615"
FT MOD_RES 111
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O43320"
FT CARBOHYD 78
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 207 AA; 23753 MW; 1C7A11C8BA3164BC CRC64;
MAEVGGVFAS LDWDLQGFSS SLGNVPLADS PGFLNERLGQ IEGKLQRGSP TDFAHLKGIL
RRRQLYCRTG FHLEIFPNGT VHGTRHDHSR FGILEFISLA VGLISIRGVD SGLYLGMNER
GELFGSKKLT RECVFREQFE ENWYNTYAST LYKHSDSERQ YYVALNKDGS PREGYRTKRH
QKFTHFLPRP VDPSKLPSMS RDLFRYR
