FGF16_MOUSE
ID FGF16_MOUSE Reviewed; 207 AA.
AC Q9ESL8; A2RTU5; Q9ERQ5;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Fibroblast growth factor 16;
DE Short=FGF-16;
GN Name=Fgf16;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Itoh N.;
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Heart;
RX PubMed=12619867; DOI=10.1023/a:1021133611130;
RA Sontag D.P., Cattini P.A.;
RT "Cloning and bacterial expression of postnatal mouse heart FGF-16.";
RL Mol. Cell. Biochem. 242:65-70(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays an important role in the regulation of embryonic
CC development, cell proliferation and cell differentiation, and is
CC required for normal cardiomyocyte proliferation and heart development.
CC {ECO:0000250|UniProtKB:O43320}.
CC -!- SUBUNIT: Interacts with FGFR1 and FGFR2.
CC {ECO:0000250|UniProtKB:O43320}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O54769}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; AB049219; BAB16405.1; -; mRNA.
DR EMBL; AF292104; AAG29501.1; -; mRNA.
DR EMBL; CH466564; EDL14069.1; -; Genomic_DNA.
DR EMBL; BC132641; AAI32642.1; -; mRNA.
DR EMBL; BC137993; AAI37994.1; -; mRNA.
DR CCDS; CCDS30336.1; -.
DR RefSeq; NP_085117.2; NM_030614.2.
DR AlphaFoldDB; Q9ESL8; -.
DR SMR; Q9ESL8; -.
DR STRING; 10090.ENSMUSP00000033581; -.
DR GlyGen; Q9ESL8; 1 site.
DR iPTMnet; Q9ESL8; -.
DR PhosphoSitePlus; Q9ESL8; -.
DR PaxDb; Q9ESL8; -.
DR PRIDE; Q9ESL8; -.
DR Antibodypedia; 72310; 247 antibodies from 27 providers.
DR DNASU; 80903; -.
DR Ensembl; ENSMUST00000033581; ENSMUSP00000033581; ENSMUSG00000031230.
DR GeneID; 80903; -.
DR KEGG; mmu:80903; -.
DR UCSC; uc009uba.1; mouse.
DR CTD; 8823; -.
DR MGI; MGI:1931627; Fgf16.
DR VEuPathDB; HostDB:ENSMUSG00000031230; -.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000160087; -.
DR HOGENOM; CLU_081609_0_0_1; -.
DR InParanoid; Q9ESL8; -.
DR OMA; NRTKKHQ; -.
DR OrthoDB; 1097566at2759; -.
DR PhylomeDB; Q9ESL8; -.
DR TreeFam; TF317805; -.
DR Reactome; R-MMU-109704; PI3K Cascade.
DR Reactome; R-MMU-1257604; PIP3 activates AKT signaling.
DR Reactome; R-MMU-190322; FGFR4 ligand binding and activation.
DR Reactome; R-MMU-190372; FGFR3c ligand binding and activation.
DR Reactome; R-MMU-190375; FGFR2c ligand binding and activation.
DR Reactome; R-MMU-5654221; Phospholipase C-mediated cascade, FGFR2.
DR Reactome; R-MMU-5654227; Phospholipase C-mediated cascade, FGFR3.
DR Reactome; R-MMU-5654228; Phospholipase C-mediated cascade, FGFR4.
DR Reactome; R-MMU-5654695; PI-3K cascade:FGFR2.
DR Reactome; R-MMU-5654699; SHC-mediated cascade:FGFR2.
DR Reactome; R-MMU-5654700; FRS-mediated FGFR2 signaling.
DR Reactome; R-MMU-5654704; SHC-mediated cascade:FGFR3.
DR Reactome; R-MMU-5654706; FRS-mediated FGFR3 signaling.
DR Reactome; R-MMU-5654710; PI-3K cascade:FGFR3.
DR Reactome; R-MMU-5654712; FRS-mediated FGFR4 signaling.
DR Reactome; R-MMU-5654719; SHC-mediated cascade:FGFR4.
DR Reactome; R-MMU-5654720; PI-3K cascade:FGFR4.
DR Reactome; R-MMU-5654727; Negative regulation of FGFR2 signaling.
DR Reactome; R-MMU-5654732; Negative regulation of FGFR3 signaling.
DR Reactome; R-MMU-5654733; Negative regulation of FGFR4 signaling.
DR Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
DR Reactome; R-MMU-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR BioGRID-ORCS; 80903; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q9ESL8; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9ESL8; protein.
DR Bgee; ENSMUSG00000031230; Expressed in mesenchyme of tongue and 38 other tissues.
DR Genevisible; Q9ESL8; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; ISO:MGI.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; ISO:MGI.
DR GO; GO:0070349; P:positive regulation of brown fat cell proliferation; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:2000546; P:positive regulation of endothelial cell chemotaxis to fibroblast growth factor; ISO:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028285; FGF16.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF27; PTHR11486:SF27; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Growth factor; Phosphoprotein; Reference proteome; Secreted.
FT CHAIN 1..207
FT /note="Fibroblast growth factor 16"
FT /id="PRO_0000147614"
FT MOD_RES 111
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O43320"
FT CARBOHYD 78
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 16
FT /note="H -> Q (in Ref. 2; AAG29501)"
FT /evidence="ECO:0000305"
FT CONFLICT 150
FT /note="T -> A (in Ref. 2; AAG29501)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 207 AA; 23778 MW; D8AD03EBDABDB5F8 CRC64;
MAEVGGVFAS LDWDLHGFSS SLGNVPLADS PGFLNERLGQ IEGKLQRGSP TDFAHLKGIL
RRRQLYCRTG FHLEIFPNGT VHGTRHDHSR FGILEFISLA VGLISIRGVD SGLYLGMNER
GELYGSKKLT RECVFREQFE ENWYNTYAST LYKHSDSERQ YYVALNKDGS PREGYRTKRH
QKFTHFLPRP VDPSKLPSMS RDLFRYR
