FGF13_PONAB
ID FGF13_PONAB Reviewed; 245 AA.
AC Q5RDS9;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Fibroblast growth factor 13;
DE Short=FGF-13;
GN Name=FGF13;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Microtubule-binding protein which directly binds tubulin and
CC is involved in both polymerization and stabilization of microtubules
CC (By similarity). Through its action on microtubules, may participate in
CC the refinement of axons by negatively regulating axonal and leading
CC processes branching (By similarity). Plays a crucial role in neuron
CC polarization and migration in the cerebral cortex and the hippocampus
CC (By similarity). Regulates voltage-gated sodium channels transport and
CC function (By similarity). May also play a role in MAPK signaling (By
CC similarity). Required for the development of axonal initial segment-
CC targeting inhibitory GABAergic synapses made by chandelier neurons (By
CC similarity). {ECO:0000250|UniProtKB:P70377,
CC ECO:0000250|UniProtKB:Q92913}.
CC -!- SUBUNIT: Interacts with SCN8A; regulates SCN8A activity. Interacts with
CC SCN1A; may regulate SCN1A activity. Interacts with SCN5A; the
CC interaction is direct and may regulate SNC5A density at membranes and
CC function. May also interact with SCN2A and SCN11A. Interacts with
CC MAPK8IP2; may regulate the MAPK8IP2 scaffolding activity.
CC {ECO:0000250|UniProtKB:Q92913}.
CC -!- SUBCELLULAR LOCATION: Cell projection, filopodium
CC {ECO:0000250|UniProtKB:P70377}. Cell projection, growth cone
CC {ECO:0000250|UniProtKB:P70377}. Cell projection, dendrite
CC {ECO:0000250|UniProtKB:P70377}. Cell membrane, sarcolemma
CC {ECO:0000250|UniProtKB:P70377}. Cytoplasm
CC {ECO:0000250|UniProtKB:P70377}. Nucleus {ECO:0000250|UniProtKB:P61329}.
CC Note=Not secreted. Localizes to the lateral membrane and intercalated
CC disks of myocytes. {ECO:0000250|UniProtKB:P70377}.
CC -!- PTM: May be phosphorylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; CR857820; CAH90078.1; -; mRNA.
DR RefSeq; NP_001128768.1; NM_001135296.1.
DR AlphaFoldDB; Q5RDS9; -.
DR SMR; Q5RDS9; -.
DR STRING; 9601.ENSPPYP00000023260; -.
DR Ensembl; ENSPPYT00000041339; ENSPPYP00000026918; ENSPPYG00000020777.
DR GeneID; 100189666; -.
DR KEGG; pon:100189666; -.
DR CTD; 2258; -.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000163347; -.
DR HOGENOM; CLU_081609_2_0_1; -.
DR InParanoid; Q5RDS9; -.
DR OMA; LYPSEHF; -.
DR OrthoDB; 1192273at2759; -.
DR TreeFam; TF317805; -.
DR Proteomes; UP000001595; Chromosome X.
DR GO; GO:0030424; C:axon; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0030425; C:dendrite; ISS:UniProtKB.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0030175; C:filopodium; ISS:UniProtKB.
DR GO; GO:0030426; C:growth cone; ISS:UniProtKB.
DR GO; GO:0014704; C:intercalated disc; ISS:UniProtKB.
DR GO; GO:0005874; C:microtubule; ISS:UniProtKB.
DR GO; GO:0043005; C:neuron projection; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0048487; F:beta-tubulin binding; ISS:UniProtKB.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR GO; GO:0017080; F:sodium channel regulator activity; ISS:UniProtKB.
DR GO; GO:0044325; F:transmembrane transporter binding; ISS:UniProtKB.
DR GO; GO:0021795; P:cerebral cortex cell migration; ISS:UniProtKB.
DR GO; GO:0045200; P:establishment of neuroblast polarity; ISS:UniProtKB.
DR GO; GO:0021766; P:hippocampus development; ISS:UniProtKB.
DR GO; GO:1904862; P:inhibitory synapse assembly; ISS:UniProtKB.
DR GO; GO:0007612; P:learning; ISS:UniProtKB.
DR GO; GO:0007613; P:memory; ISS:UniProtKB.
DR GO; GO:0046785; P:microtubule polymerization; ISS:UniProtKB.
DR GO; GO:0048671; P:negative regulation of collateral sprouting; ISS:UniProtKB.
DR GO; GO:0007026; P:negative regulation of microtubule depolymerization; ISS:UniProtKB.
DR GO; GO:0001764; P:neuron migration; ISS:UniProtKB.
DR GO; GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028279; FGF13.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF145; PTHR11486:SF145; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cell projection; Cytoplasm; Membrane; Microtubule;
KW Neurogenesis; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..245
FT /note="Fibroblast growth factor 13"
FT /id="PRO_0000147609"
FT REGION 1..62
FT /note="Mediates targeting to the nucleus"
FT /evidence="ECO:0000250"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 67..201
FT /note="Mediates interaction with sodium channels"
FT /evidence="ECO:0000250"
FT REGION 213..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 208
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q92913"
SQ SEQUENCE 245 AA; 27564 MW; 30FB62C6B2669F29 CRC64;
MAAAIASSLI RQKRQARERE KSNACKCVSS PSKGKTSCDK NKLNVFSRVK LFGSKKRRRR
RPEPQLKGIV TKLYSRQGYH LQLQADGTID GTKDEDSTYT LFNLIPVGLR VVAIQGVQTK
LYLAMNSEGY LYTSELFTPE CKFKESVFEN YYVTYSSMIY RQQQSGRGWY LGLNKEGEIM
KGNHVKKNKP AAHFLPKPLK VAMYKEPSLH DLTEFSRSGS GTPTKSRSVS GVLNGGKSMS
HNEST
