FGF10_MOUSE
ID FGF10_MOUSE Reviewed; 209 AA.
AC O35565; Q543V5;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Fibroblast growth factor 10;
DE Short=FGF-10;
DE AltName: Full=Keratinocyte growth factor 2;
DE Flags: Precursor;
GN Name=Fgf10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9332392; DOI=10.1016/s0378-1119(97)00187-x;
RA Tagashira S., Harada H., Katsumata T., Itoh N., Nakatsuka M.;
RT "Cloning of mouse FGF10 and up-regulation of its gene expression during
RT wound healing.";
RL Gene 197:399-404(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lung;
RA Duan D.R., Florence C.;
RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hippocampus, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays an important role in the regulation of embryonic
CC development, cell proliferation and cell differentiation. Required for
CC normal branching morphogenesis. May play a role in wound healing.
CC -!- SUBUNIT: Interacts with FGFR1 and FGFR2. Interacts with FGFBP1 (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed abundantly in embryos and the lung, and
CC at much lower levels in brain and heart.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; D89080; BAA22836.1; -; mRNA.
DR EMBL; U94517; AAD00761.1; -; mRNA.
DR EMBL; AK034742; BAC28816.1; -; mRNA.
DR EMBL; AK045267; BAC32287.1; -; mRNA.
DR EMBL; AK085244; BAC39398.1; -; mRNA.
DR EMBL; AK141633; BAE24777.1; -; mRNA.
DR EMBL; BC048229; AAH48229.1; -; mRNA.
DR CCDS; CCDS26795.1; -.
DR RefSeq; NP_032028.1; NM_008002.4.
DR AlphaFoldDB; O35565; -.
DR SMR; O35565; -.
DR BioGRID; 199639; 1.
DR STRING; 10090.ENSMUSP00000022246; -.
DR GlyGen; O35565; 2 sites.
DR PhosphoSitePlus; O35565; -.
DR PaxDb; O35565; -.
DR PRIDE; O35565; -.
DR Antibodypedia; 4149; 424 antibodies from 37 providers.
DR DNASU; 14165; -.
DR Ensembl; ENSMUST00000022246; ENSMUSP00000022246; ENSMUSG00000021732.
DR GeneID; 14165; -.
DR KEGG; mmu:14165; -.
DR UCSC; uc007ryv.2; mouse.
DR CTD; 2255; -.
DR MGI; MGI:1099809; Fgf10.
DR VEuPathDB; HostDB:ENSMUSG00000021732; -.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000158907; -.
DR HOGENOM; CLU_081609_3_1_1; -.
DR InParanoid; O35565; -.
DR OMA; KWILTHG; -.
DR OrthoDB; 1340221at2759; -.
DR PhylomeDB; O35565; -.
DR TreeFam; TF317805; -.
DR Reactome; R-MMU-109704; PI3K Cascade.
DR Reactome; R-MMU-1257604; PIP3 activates AKT signaling.
DR Reactome; R-MMU-190370; FGFR1b ligand binding and activation.
DR Reactome; R-MMU-190377; FGFR2b ligand binding and activation.
DR Reactome; R-MMU-5654219; Phospholipase C-mediated cascade: FGFR1.
DR Reactome; R-MMU-5654221; Phospholipase C-mediated cascade, FGFR2.
DR Reactome; R-MMU-5654687; Downstream signaling of activated FGFR1.
DR Reactome; R-MMU-5654688; SHC-mediated cascade:FGFR1.
DR Reactome; R-MMU-5654689; PI-3K cascade:FGFR1.
DR Reactome; R-MMU-5654693; FRS-mediated FGFR1 signaling.
DR Reactome; R-MMU-5654695; PI-3K cascade:FGFR2.
DR Reactome; R-MMU-5654699; SHC-mediated cascade:FGFR2.
DR Reactome; R-MMU-5654700; FRS-mediated FGFR2 signaling.
DR Reactome; R-MMU-5654726; Negative regulation of FGFR1 signaling.
DR Reactome; R-MMU-5654727; Negative regulation of FGFR2 signaling.
DR Reactome; R-MMU-5658623; FGFRL1 modulation of FGFR1 signaling.
DR Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
DR Reactome; R-MMU-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR BioGRID-ORCS; 14165; 1 hit in 110 CRISPR screens.
DR ChiTaRS; Fgf10; mouse.
DR PRO; PR:O35565; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; O35565; protein.
DR Bgee; ENSMUSG00000021732; Expressed in lung mesenchyme and 167 other tissues.
DR Genevisible; O35565; MM.
DR GO; GO:0009986; C:cell surface; ISO:MGI.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0042056; F:chemoattractant activity; IDA:MGI.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; ISO:MGI.
DR GO; GO:0008083; F:growth factor activity; ISO:MGI.
DR GO; GO:0008201; F:heparin binding; ISO:MGI.
DR GO; GO:0005111; F:type 2 fibroblast growth factor receptor binding; ISO:MGI.
DR GO; GO:0031532; P:actin cytoskeleton reorganization; ISO:MGI.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0048645; P:animal organ formation; IMP:MGI.
DR GO; GO:0009887; P:animal organ morphogenesis; IDA:MGI.
DR GO; GO:0048514; P:blood vessel morphogenesis; IMP:MGI.
DR GO; GO:0001974; P:blood vessel remodeling; IGI:MGI.
DR GO; GO:0060667; P:branch elongation involved in salivary gland morphogenesis; IMP:MGI.
DR GO; GO:0060445; P:branching involved in salivary gland morphogenesis; IDA:MGI.
DR GO; GO:0048754; P:branching morphogenesis of an epithelial tube; ISO:MGI.
DR GO; GO:0060436; P:bronchiole morphogenesis; IMP:MGI.
DR GO; GO:0060449; P:bud elongation involved in lung branching; IGI:MGI.
DR GO; GO:0060447; P:bud outgrowth involved in lung branching; ISO:MGI.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0008283; P:cell population proliferation; IDA:MGI.
DR GO; GO:0007267; P:cell-cell signaling; IDA:MGI.
DR GO; GO:0006935; P:chemotaxis; IDA:MGI.
DR GO; GO:0007368; P:determination of left/right symmetry; IMP:MGI.
DR GO; GO:0048565; P:digestive tract development; IMP:MGI.
DR GO; GO:0031076; P:embryonic camera-type eye development; IMP:MGI.
DR GO; GO:0048566; P:embryonic digestive tract development; IMP:MGI.
DR GO; GO:0048557; P:embryonic digestive tract morphogenesis; IMP:MGI.
DR GO; GO:0030538; P:embryonic genitalia morphogenesis; IMP:MGI.
DR GO; GO:0009880; P:embryonic pattern specification; IMP:MGI.
DR GO; GO:0001935; P:endothelial cell proliferation; IDA:MGI.
DR GO; GO:0008544; P:epidermis development; IMP:MGI.
DR GO; GO:0048730; P:epidermis morphogenesis; IMP:MGI.
DR GO; GO:0030855; P:epithelial cell differentiation; IDA:MGI.
DR GO; GO:0050673; P:epithelial cell proliferation; IDA:MGI.
DR GO; GO:0060664; P:epithelial cell proliferation involved in salivary gland morphogenesis; IMP:MGI.
DR GO; GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IDA:MGI.
DR GO; GO:0070371; P:ERK1 and ERK2 cascade; IMP:MGI.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IGI:MGI.
DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IMP:MGI.
DR GO; GO:0048807; P:female genitalia morphogenesis; IMP:MGI.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0060595; P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification; IDA:MGI.
DR GO; GO:0048144; P:fibroblast proliferation; IMP:MGI.
DR GO; GO:0031069; P:hair follicle morphogenesis; IMP:MGI.
DR GO; GO:0070384; P:Harderian gland development; IMP:MGI.
DR GO; GO:0050930; P:induction of positive chemotaxis; IDA:MGI.
DR GO; GO:0042472; P:inner ear morphogenesis; IMP:MGI.
DR GO; GO:0043616; P:keratinocyte proliferation; IMP:MGI.
DR GO; GO:0032808; P:lacrimal gland development; IMP:MGI.
DR GO; GO:0060174; P:limb bud formation; IMP:MGI.
DR GO; GO:0060173; P:limb development; IMP:MGI.
DR GO; GO:0035108; P:limb morphogenesis; IMP:MGI.
DR GO; GO:0048286; P:lung alveolus development; IMP:MGI.
DR GO; GO:0030324; P:lung development; IDA:MGI.
DR GO; GO:0060428; P:lung epithelium development; ISO:MGI.
DR GO; GO:0060425; P:lung morphogenesis; IMP:MGI.
DR GO; GO:0061115; P:lung proximal/distal axis specification; IDA:MGI.
DR GO; GO:0060430; P:lung saccule development; ISO:MGI.
DR GO; GO:0048808; P:male genitalia morphogenesis; IMP:MGI.
DR GO; GO:0060615; P:mammary gland bud formation; IMP:MGI.
DR GO; GO:0060594; P:mammary gland specification; IGI:MGI.
DR GO; GO:0060915; P:mesenchymal cell differentiation involved in lung development; IGI:MGI.
DR GO; GO:0060496; P:mesenchymal-epithelial cell signaling involved in lung development; IDA:MGI.
DR GO; GO:0001823; P:mesonephros development; IEA:Ensembl.
DR GO; GO:0003338; P:metanephros morphogenesis; IMP:MGI.
DR GO; GO:0000278; P:mitotic cell cycle; IMP:MGI.
DR GO; GO:0042693; P:muscle cell fate commitment; IMP:MGI.
DR GO; GO:0030857; P:negative regulation of epithelial cell differentiation; IDA:MGI.
DR GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IMP:MGI.
DR GO; GO:2000647; P:negative regulation of stem cell proliferation; IDA:MGI.
DR GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IMP:MGI.
DR GO; GO:0035265; P:organ growth; IMP:MGI.
DR GO; GO:0001759; P:organ induction; IGI:MGI.
DR GO; GO:0030916; P:otic vesicle formation; IGI:MGI.
DR GO; GO:0031016; P:pancreas development; IMP:MGI.
DR GO; GO:0021983; P:pituitary gland development; IMP:MGI.
DR GO; GO:0050918; P:positive chemotaxis; IDA:MGI.
DR GO; GO:0032781; P:positive regulation of ATP-dependent activity; ISO:MGI.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IMP:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0045739; P:positive regulation of DNA repair; ISO:MGI.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:MGI.
DR GO; GO:0010634; P:positive regulation of epithelial cell migration; IDA:MGI.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IDA:MGI.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:MGI.
DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; IMP:MGI.
DR GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; ISO:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0071338; P:positive regulation of hair follicle cell proliferation; ISO:MGI.
DR GO; GO:0051549; P:positive regulation of keratinocyte migration; ISO:MGI.
DR GO; GO:0010838; P:positive regulation of keratinocyte proliferation; IMP:MGI.
DR GO; GO:0050671; P:positive regulation of lymphocyte proliferation; ISO:MGI.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:MGI.
DR GO; GO:0045931; P:positive regulation of mitotic cell cycle; IMP:MGI.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IGI:MGI.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:MGI.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; ISO:MGI.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; IDA:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:CACAO.
DR GO; GO:0050677; P:positive regulation of urothelial cell proliferation; ISO:MGI.
DR GO; GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; IMP:MGI.
DR GO; GO:0070352; P:positive regulation of white fat cell proliferation; IMP:MGI.
DR GO; GO:0030177; P:positive regulation of Wnt signaling pathway; IMP:MGI.
DR GO; GO:0060513; P:prostatic bud formation; IGI:MGI.
DR GO; GO:0034394; P:protein localization to cell surface; ISO:MGI.
DR GO; GO:0060019; P:radial glial cell differentiation; IMP:UniProtKB.
DR GO; GO:0032925; P:regulation of activin receptor signaling pathway; IMP:MGI.
DR GO; GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; IDA:MGI.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IMP:MGI.
DR GO; GO:0046877; P:regulation of saliva secretion; ISO:MGI.
DR GO; GO:0008589; P:regulation of smoothened signaling pathway; IMP:MGI.
DR GO; GO:0060541; P:respiratory system development; IDA:MGI.
DR GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0007431; P:salivary gland development; ISO:MGI.
DR GO; GO:0007435; P:salivary gland morphogenesis; IMP:MGI.
DR GO; GO:0061033; P:secretion by lung epithelial cell involved in lung growth; ISO:MGI.
DR GO; GO:0060879; P:semicircular canal fusion; IMP:MGI.
DR GO; GO:0048752; P:semicircular canal morphogenesis; IGI:MGI.
DR GO; GO:0051145; P:smooth muscle cell differentiation; IMP:MGI.
DR GO; GO:0035019; P:somatic stem cell population maintenance; IMP:MGI.
DR GO; GO:0048536; P:spleen development; IMP:MGI.
DR GO; GO:0072089; P:stem cell proliferation; IDA:MGI.
DR GO; GO:0060661; P:submandibular salivary gland formation; IMP:MGI.
DR GO; GO:0070075; P:tear secretion; ISO:MGI.
DR GO; GO:0048538; P:thymus development; ISO:MGI.
DR GO; GO:0030878; P:thyroid gland development; IMP:MGI.
DR GO; GO:0042246; P:tissue regeneration; IEA:Ensembl.
DR GO; GO:0060510; P:type II pneumocyte differentiation; IDA:MGI.
DR GO; GO:0050674; P:urothelial cell proliferation; ISO:MGI.
DR GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IMP:MGI.
DR GO; GO:0050872; P:white fat cell differentiation; IMP:MGI.
DR GO; GO:0070343; P:white fat cell proliferation; IMP:MGI.
DR GO; GO:0016055; P:Wnt signaling pathway; IMP:MGI.
DR GO; GO:0042060; P:wound healing; ISO:MGI.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028252; FGF10.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF21; PTHR11486:SF21; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..36
FT /evidence="ECO:0000255"
FT CHAIN 37..209
FT /note="Fibroblast growth factor 10"
FT /id="PRO_0000008982"
FT CARBOHYD 50
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 197
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 209 AA; 23597 MW; 7FD22227BF4943CC CRC64;
MWKWILTHCA SAFPHLPGCC CCFLLLFLVS SFPVTCQALG QDMVSQEATN CSSSSSSFSS
PSSAGRHVRS YNHLQGDVRW RRLFSFTKYF LTIEKNGKVS GTKNEDCPYS VLEITSVEIG
VVAVKAINSN YYLAMNKKGK LYGSKEFNND CKLKERIEEN GYNTYASFNW QHNGRQMYVA
LNGKGAPRRG QKTRRKNTSA HFLPMTIQT
