AK17B_MOUSE
ID AK17B_MOUSE Reviewed; 959 AA.
AC A2A3V1; B0QZD2; Q0P534; Q8BR01; Q8C6P6;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=A-kinase anchor protein 17B;
DE Short=AKAP-17B;
DE AltName: Full=Protein Talia;
DE AltName: Full=Protein kinase A-anchoring protein 17B;
DE Short=PRKA17B;
DE AltName: Full=Splicing factor, arginine/serine-rich 17B;
GN Name=Akap17b; Synonyms=Sfrs17b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-304.
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, and Oviduct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 508-959.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=17302988; DOI=10.1186/1471-213x-7-8;
RA Frankenberg S., Smith L., Greenfield A., Zernicka-Goetz M.;
RT "Novel gene expression patterns along the proximo-distal axis of the mouse
RT embryo before gastrulation.";
RL BMC Dev. Biol. 7:8-8(2007).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-671 AND SER-678, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Splice factor regulating alternative splice site selection
CC for certain mRNA precursors. {ECO:0000250}.
CC -!- SUBUNIT: Monomer. Component of the spliceosome (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC {ECO:0000269|PubMed:17302988}.
CC -!- DEVELOPMENTAL STAGE: Uniformally expressed in the extraembryonic
CC ectoderm at 5.5 dpc. Restricted to the distal part of the
CC extraembryonic ectoderm at 6.5 dpc-7.5 dpc.
CC {ECO:0000269|PubMed:17302988}.
CC -!- MISCELLANEOUS: 'Talia' means 'waistline' in Polish.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC35651.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAQ12496.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL450397; CAM13291.2; -; Genomic_DNA.
DR EMBL; AL450397; CAQ12496.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AK046007; BAC32570.2; -; mRNA.
DR EMBL; AK054091; BAC35651.1; ALT_FRAME; mRNA.
DR EMBL; BC120735; AAI20736.1; -; mRNA.
DR EMBL; BC131917; AAI31918.1; -; mRNA.
DR CCDS; CCDS40924.1; -.
DR RefSeq; NP_001075425.1; NM_001081956.1.
DR RefSeq; XP_006541446.1; XM_006541383.3.
DR RefSeq; XP_006541447.1; XM_006541384.3.
DR RefSeq; XP_017174021.1; XM_017318532.1.
DR AlphaFoldDB; A2A3V1; -.
DR STRING; 10090.ENSMUSP00000052042; -.
DR iPTMnet; A2A3V1; -.
DR PhosphoSitePlus; A2A3V1; -.
DR EPD; A2A3V1; -.
DR PaxDb; A2A3V1; -.
DR PeptideAtlas; A2A3V1; -.
DR PRIDE; A2A3V1; -.
DR ProteomicsDB; 282058; -.
DR Ensembl; ENSMUST00000051906; ENSMUSP00000052042; ENSMUSG00000059708.
DR GeneID; 338351; -.
DR KEGG; mmu:338351; -.
DR UCSC; uc009sxp.1; mouse.
DR CTD; 338351; -.
DR MGI; MGI:2443758; Akap17b.
DR VEuPathDB; HostDB:ENSMUSG00000059708; -.
DR eggNOG; KOG2891; Eukaryota.
DR GeneTree; ENSGT00440000039314; -.
DR HOGENOM; CLU_356770_0_0_1; -.
DR InParanoid; A2A3V1; -.
DR OMA; HLPNQEE; -.
DR OrthoDB; 635256at2759; -.
DR TreeFam; TF320443; -.
DR BioGRID-ORCS; 338351; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Akap17b; mouse.
DR PRO; PR:A2A3V1; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; A2A3V1; protein.
DR Bgee; ENSMUSG00000059708; Expressed in animal zygote and 244 other tissues.
DR ExpressionAtlas; A2A3V1; baseline and differential.
DR Genevisible; A2A3V1; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0051018; F:protein kinase A binding; ISO:MGI.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 1: Evidence at protein level;
KW Coiled coil; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW Reference proteome; RNA-binding; Spliceosome.
FT CHAIN 1..959
FT /note="A-kinase anchor protein 17B"
FT /id="PRO_0000343419"
FT DOMAIN 145..253
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 284..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 827..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 261..334
FT /evidence="ECO:0000255"
FT COMPBIAS 284..307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..331
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 671
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 678
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 126
FT /note="E -> K (in Ref. 2; BAC35651)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 959 AA; 111066 MW; B8663A72ECD8F434 CRC64;
MTVTVVYDNS EATELCAAQH LYLKPIAKLM INVLLPECIE PVRPFSNWEV LDQLKSLICP
DQFTTVRLSK STKDFIRFEG EAETRSLVQI LKAKLHGKII KLNGLKTDLK VVATDAQGEW
EHFPKEKEAS VIEGAEEQDH DKGPDSIYFE GLPCKWFAPK GSSGEKPCEE ILRVVFESFG
KIKNVDIPML DPYREVMTGG SFGGLNFGLQ TFEAFIQYQE STDFIKAMES LRGMKLMLKG
DDGKALACNI KVMFDTTKHF SEGAIQRRNQ ERLKLQELEE ERKKEKKREE EVAERKRKDE
VRKAQEKRKK ARDRRRALKE RDRHRQRKEK VKTKPEARQE LDSSGEWEER KYLLARRRVE
ALRLLRVLLK KIAVWMRKEK NLKPCQTHIS LLLNCLGSTQ CNPQEVGVMK SEAHHTPGTA
LKSPEEEELN TRHLLDWEEM PSYQASTLDL SQKAEKRCYQ ASKSDNKQKQ KGKKKTKAQL
QKSSHTPGVK QMRHSARKEE TGKVLSDGCD YSLVSDQNSL QSTMIADQSL AKEDHASSNE
SHSSRQAVIN RGRKQKIYET DEFIDYLLNY YQTPEYARFC LEASHLTSTC QWQRDVYAKG
DGFQIYLRKQ GYHSNSLSEE ESLQGIEQDE EQDWPQVYIK DPESKSQKTG KINYAKEFTK
KLKNHCKDIA SETDEHLSPT DGESYPVEKI HSHGVKDSQH IRKSPVSSSL RSVDVGLPLA
DFLEEISSDS ECFSETLSMN QEEEERSMAV YNSSPEKRPL GTDKISTCKQ KTKSSQQTLC
SEWKHDNEGK YSKHRVRAPG KRSKSELRYS WLEEEGDSIR VDKNISKTRG KLAPKHMLDE
GQYHESSSSD ELESTTRKKR RLTSGMFDQN VKYRPLHMPS MPPKRARAFY LGYFSRKRQT
PWKSEYNQDV RRFKRYENSE DYTLDSDNYY VSHDDNQEHI EYGSYLGDSY SSSLYFKMF
