ID   AJM1_HUMAN              Reviewed;         976 AA.
AC   C9J069;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Apical junction component 1 homolog {ECO:0000305};
GN   Name=AJM1 {ECO:0000312|HGNC:HGNC:37284}; Synonyms=C9orf172;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
CC   -!- FUNCTION: May be involved in the control of adherens junction
CC       integrity. {ECO:0000250|UniProtKB:A0A1C3NSL9}.
CC   -!- SUBCELLULAR LOCATION: Apical cell membrane
CC       {ECO:0000250|UniProtKB:A0A1C3NSL9}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:A0A1C3NSL9}. Cell junction, adherens junction
CC       {ECO:0000250|UniProtKB:A0A1C3NSL9}.
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DR   EMBL; AL355987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS48059.1; -.
DR   RefSeq; NP_001073951.2; NM_001080482.2.
DR   AlphaFoldDB; C9J069; -.
DR   BioGRID; 133280; 2.
DR   STRING; 9606.ENSP00000412388; -.
DR   iPTMnet; C9J069; -.
DR   PhosphoSitePlus; C9J069; -.
DR   BioMuta; C9orf172; -.
DR   jPOST; C9J069; -.
DR   MassIVE; C9J069; -.
DR   PaxDb; C9J069; -.
DR   PeptideAtlas; C9J069; -.
DR   PRIDE; C9J069; -.
DR   ProteomicsDB; 7898; -.
DR   Antibodypedia; 32260; 47 antibodies from 10 providers.
DR   DNASU; 389813; -.
DR   Ensembl; ENST00000436881.3; ENSP00000412388.1; ENSG00000232434.3.
DR   GeneID; 389813; -.
DR   KEGG; hsa:389813; -.
DR   MANE-Select; ENST00000436881.3; ENSP00000412388.1; NM_001080482.5; NP_001073951.2.
DR   UCSC; uc011meh.3; human.
DR   CTD; 389813; -.
DR   GeneCards; AJM1; -.
DR   HGNC; HGNC:37284; AJM1.
DR   HPA; ENSG00000232434; Tissue enhanced (brain, pituitary gland).
DR   neXtProt; NX_C9J069; -.
DR   OpenTargets; ENSG00000232434; -.
DR   PharmGKB; PA165585544; -.
DR   VEuPathDB; HostDB:ENSG00000232434; -.
DR   eggNOG; ENOG502QQYV; Eukaryota.
DR   GeneTree; ENSGT00390000016543; -.
DR   HOGENOM; CLU_012765_0_0_1; -.
DR   InParanoid; C9J069; -.
DR   OMA; KEKTHDN; -.
DR   OrthoDB; 71355at2759; -.
DR   PhylomeDB; C9J069; -.
DR   TreeFam; TF323946; -.
DR   PathwayCommons; C9J069; -.
DR   SignaLink; C9J069; -.
DR   BioGRID-ORCS; 389813; 18 hits in 1003 CRISPR screens.
DR   ChiTaRS; C9orf172; human.
DR   GenomeRNAi; 389813; -.
DR   Pharos; C9J069; Tdark.
DR   PRO; PR:C9J069; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; C9J069; protein.
DR   Bgee; ENSG00000232434; Expressed in right hemisphere of cerebellum and 94 other tissues.
DR   Genevisible; C9J069; HS.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0043296; C:apical junction complex; IBA:GO_Central.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0045216; P:cell-cell junction organization; IBA:GO_Central.
DR   InterPro; IPR038825; Apical_junction.
DR   PANTHER; PTHR21517; PTHR21517; 1.
PE   3: Inferred from homology;
KW   Cell junction; Cell membrane; Cell projection; Membrane; Methylation;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..976
FT                   /note="Apical junction component 1 homolog"
FT                   /id="PRO_0000392544"
FT   REGION          21..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          61..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          220..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          264..294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          412..443
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          539..574
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          614..660
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          855..888
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..93
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         52
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A2AJA9"
FT   MOD_RES         129
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A2AJA9"
FT   MOD_RES         322
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:A2AJA9"
FT   MOD_RES         468
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A2AJA9"
FT   MOD_RES         509
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A2AJA9"
FT   MOD_RES         512
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A2AJA9"
FT   MOD_RES         749
FT                   /note="Asymmetric dimethylarginine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:A2AJA9"
FT   MOD_RES         749
FT                   /note="Omega-N-methylarginine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:A2AJA9"
SQ   SEQUENCE   976 AA;  106650 MW;  7DB1CCE956BCA47D CRC64;
     MTRTDPPDLL VSTVYQDIKV ATPGPASKCS PCERSVARPA EPAPFNKRHC RSFDFLEALD
     GPAMETLPEP PPPESAVPRA RTREAEPRRR ARSKSAPRAP PGLTPAPASP PVLPRRGREA
     QRAARAEASP RREPAYPALR ALANELHPIK LQPQRGGPGR VAPLCAAAGR CAPPEPPAGP
     APHVRCRLDI KPDDAVLQHA TRGSRSCGPT EAAHWARPAP QFHGLTVPGP RHMALSRTPT
     PSDSYCADPR AFYCDGPLPG PRDYAERRSL PFTTPPGPTQ FFYTEEPQGF RGSFAASPGP
     TFDAYYPRPY PSEELSGPSP RRMGGYYAGE VRTFPIQEPP SRSYYGEAPR AYGLPYGPRY
     VPEEPRAHST ARPFYTEDFG RYRERDVLAR TYPHPRSSPA WADWGPRPYR TLQVVPPSDP
     DPLLASWHGG TGTSPPRLAT DSRHYSRSWD NILAPGPRRE DPLGRGRSYE NLLGREVREP
     RGVSPEGRRP PVVVNLSTSP RRYAALSLSE TSLTEKGRAG EGLGRNWYVT PEITITDNDL
     RATERPSARA WELPGGRTRP PPHAAPDGPT SGRQRSLEQL DELITDLVID SRPTAGQASE
     PAADCLGPQL RRLLDSRPAG SGAPALAPPR SPPASAGSAE EPAAPGEAAD ASPEPSADED
     DLMTCSNARC RRTETMFNAC LYFKSCHSCY TYYCSRLCRR EDWDAHKARC VYGRVGSVCR
     HVLQFCRDSG PVHRAFSRIA RVGFLSRGRG VLFLGFPSPG SADNFLRFGL EGLLLSPTYL
     SLRELATHAA PLGSYARELA AAGRLYEPAE CFLLSVSVAV GPGTAPPGTP ALPAPAPRSH
     GPTVRKFAKV ALAAGSPARP PPARSREPDM ETLILTPPPG TAGLDQDGEA GRRAREVAFI
     HIQRELRLRG VFLRHEFPRV YEQLCEFVEA NRRFTPTTIY PTDRRTGRPF MCMIMAASEP
     RALDWVASAN LLDDIM