FEOB_SYNY3
ID FEOB_SYNY3 Reviewed; 614 AA.
AC P73182;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Fe(2+) transporter FeoB {ECO:0000305};
DE AltName: Full=Ferrous iron transport protein B homolog;
GN Name=feoB; OrderedLocusNames=slr1392;
OS Synechocystis sp. (strain PCC 6803 / Kazusa).
OC Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC unclassified Synechocystis.
OX NCBI_TaxID=1111708;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 6803 / Kazusa;
RX PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence analysis of the genome of the unicellular cyanobacterium
RT Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT genome and assignment of potential protein-coding regions.";
RL DNA Res. 3:109-136(1996).
CC -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake system.
CC {ECO:0000250|UniProtKB:P33650}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC {ECO:0000255|PROSITE-ProRule:PRU01048}.
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DR EMBL; BA000022; BAA17208.1; -; Genomic_DNA.
DR PIR; S75294; S75294.
DR AlphaFoldDB; P73182; -.
DR SMR; P73182; -.
DR STRING; 1148.1652285; -.
DR TCDB; 9.A.8.1.3; the ferrous iron uptake (feob) family.
DR PaxDb; P73182; -.
DR EnsemblBacteria; BAA17208; BAA17208; BAA17208.
DR KEGG; syn:slr1392; -.
DR eggNOG; COG0370; Bacteria.
DR InParanoid; P73182; -.
DR OMA; PLGYDWK; -.
DR PhylomeDB; P73182; -.
DR Proteomes; UP000001425; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR CDD; cd01879; FeoB; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003373; Fe2_transport_prot-B.
DR InterPro; IPR011640; Fe2_transport_prot_B_C.
DR InterPro; IPR030389; G_FEOB_dom.
DR InterPro; IPR011642; Gate_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF07664; FeoB_C; 1.
DR Pfam; PF02421; FeoB_N; 1.
DR Pfam; PF07670; Gate; 2.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00437; feoB; 1.
DR PROSITE; PS51711; G_FEOB; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; GTP-binding; Ion transport; Iron;
KW Iron transport; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..614
FT /note="Fe(2+) transporter FeoB"
FT /id="PRO_0000210847"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 404..424
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 466..486
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 504..524
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 558..578
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 585..605
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 18..180
FT /note="FeoB-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 25..32
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 50..54
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 71..74
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 131..134
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT BINDING 160..162
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
SQ SEQUENCE 614 AA; 67405 MW; 24587CF8F486713A CRC64;
MVSHCQRGSV QSSRPDVKKR VAFIGQPNTG KSTFFNRITK ANAAIANWPG LTVDLFRAVV
PLQGELIEFV DLPGIYDLNG FSEDERVVQR FLANYAVNLV VVVVNAAQID RQIRLLLQVQ
TLGIPAITLL NLADEAKRYG VQIDVAALQE RLGLPLYPIS AKYGTGCSRA MDAIGRAVKD
QPEAYQIPNL VNVLSDHPVA IADMETALAG VVQMPSPNAR TLTNVIDGVM LHPVFGLPIF
FASMFGVFWV IWHVGLPSAD PVDAVTGWVQ SNILEPLFSP LPTILQGLLL DGIWTGFAAL
LSFVPLVAIF FIVMGILEGS GYLSRAAYLM DALMGRLGLD GRSFVLQMMG FGCNVPAIMG
TRVMRSRGMR LLSMLVIPFS LCSARLQVFV FILAAVMPGT QGAIALFLLY LMSFVAAFTV
AAILSRFHYF QARDPFVLEL PPYRLPTFKQ VFLRVWGEMR EFVARLSMFM VIGSSLIWFL
TSFPQGSTGL ETFAGRIGSV FQPLMNPLGI NPFLTISLIF GFVAKEVQIA ALTVIYGLNN
SEAVSDQIHS TVTFAQGFSY CLFSLIYIPC LTTLGAIWGE SKSLAYTAIS VATPLVTAWL
FSFIFYQSFS WLGW
