ID   FASC_XENLA              Reviewed;         483 AA.
AC   Q91837;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Fascin;
GN   Name=fscn;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=8086462; DOI=10.1016/0167-4781(94)90267-4;
RA   Holthuis J.C.M., Schoonderwoert V.T.G., Martens G.J.M.;
RT   "A vertebrate homolog of the actin-bundling protein fascin.";
RL   Biochim. Biophys. Acta 1219:184-188(1994).
CC   -!- FUNCTION: Organizes filamentous actin into bundles.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the fascin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X75938; CAA53540.1; -; mRNA.
DR   PIR; S40128; S40128.
DR   AlphaFoldDB; Q91837; -.
DR   SMR; Q91837; -.
DR   PRIDE; Q91837; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0015629; C:actin cytoskeleton; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; ISS:UniProtKB.
DR   GO; GO:0051015; F:actin filament binding; ISS:UniProtKB.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:InterPro.
DR   GO; GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.
DR   GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR   GO; GO:0016477; P:cell migration; IEA:InterPro.
DR   CDD; cd00257; Fascin; 4.
DR   InterPro; IPR008999; Actin-crosslinking.
DR   InterPro; IPR010431; Fascin.
DR   InterPro; IPR022768; Fascin-domain.
DR   InterPro; IPR024703; Fascin_metazoans.
DR   InterPro; IPR030146; FSCN1.
DR   PANTHER; PTHR10551; PTHR10551; 1.
DR   PANTHER; PTHR10551:SF23; PTHR10551:SF23; 1.
DR   Pfam; PF06268; Fascin; 4.
DR   PIRSF; PIRSF005682; Fascin; 1.
DR   SUPFAM; SSF50405; SSF50405; 4.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..483
FT                   /note="Fascin"
FT                   /id="PRO_0000219386"
SQ   SEQUENCE   483 AA;  53023 MW;  86C7E09D70D465AC CRC64;
     MSSGPLQLGL VNCNNKYLTA EAFGFKINAS ASSLKKKQVW SLEPAGDDTS AVLLRSHLGR
     FLSADKDGKV SGESDTAGPE CRFLVSAQGD GRWALQSELF GRYFGGSEDR ISCFSPSVSP
     AEKWGVHLAM HPQFTLYSVT RKRYRRLSAS GDELSVERDV PWGVDSLITL LFQENRYSIQ
     TPDHRLLASD GSLREKPGPD TAYTLDISAG KVAFRGSDGR YLTSSGPSGT LKSGKNSKAG
     RDELFVLERS CPQVVLTAGN GGTCLQGKVL IFSANQDEES DQETFQLEIN KDTKMCAFRT
     HTGKYWTLSS NGGIQASAST LNSSCYFEID WCDRRITLKG VNGKYVTAKK NGQLSASVDT
     PGETELFLMK LINRPLIVLR GEHGFIGCRK MTGTLDSNRS IYDVFELEFN DGAYSLKDAT
     GKYWTVGSDM SVTSRCHPGW SLEFCDYNKV AIQKVNGLYL KGDHAGVLKA NAENIDSTTL
     WEY