ID   FASC_STRPU              Reviewed;         496 AA.
AC   Q05634;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Fascin;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8415664; DOI=10.1073/pnas.90.19.9115;
RA   Bryan J., Edwards R.H., Matsudaira P., Otto J., Wulfkuhle J.;
RT   "Fascin, an echinoid actin-bundling protein, is a homolog of the Drosophila
RT   singed gene product.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:9115-9119(1993).
RN   [2]
RP   CHARACTERIZATION.
RX   PubMed=731692; DOI=10.1016/0022-2836(78)90345-5;
RA   Bryan J., Kane R.E.;
RT   "Separation and interaction of the major components of sea urchin actin
RT   gel.";
RL   J. Mol. Biol. 125:207-224(1978).
RN   [3]
RP   CHARACTERIZATION.
RX   PubMed=1033188; DOI=10.1083/jcb.71.3.704;
RA   Kane R.E.;
RT   "Actin polymerization and interaction with other proteins in temperature-
RT   induced gelation of sea urchin egg extracts.";
RL   J. Cell Biol. 71:704-714(1976).
CC   -!- FUNCTION: Acts as an actin bundling protein.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the fascin family. {ECO:0000305}.
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DR   EMBL; L12047; AAC37183.1; -; mRNA.
DR   RefSeq; NP_999701.1; NM_214536.1.
DR   AlphaFoldDB; Q05634; -.
DR   SMR; Q05634; -.
DR   STRING; 7668.SPU_010943-tr; -.
DR   EnsemblMetazoa; NM_214536; NP_999701; GeneID_373309.
DR   GeneID; 373309; -.
DR   KEGG; spu:373309; -.
DR   CTD; 6624; -.
DR   eggNOG; ENOG502QPRX; Eukaryota.
DR   HOGENOM; CLU_030960_2_0_1; -.
DR   OMA; GHETFQL; -.
DR   OrthoDB; 1419861at2759; -.
DR   PhylomeDB; Q05634; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0015629; C:actin cytoskeleton; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0003779; F:actin binding; ISS:UniProtKB.
DR   GO; GO:0051015; F:actin filament binding; ISS:UniProtKB.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:InterPro.
DR   GO; GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.
DR   GO; GO:0051017; P:actin filament bundle assembly; IBA:GO_Central.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0007163; P:establishment or maintenance of cell polarity; IBA:GO_Central.
DR   CDD; cd00257; Fascin; 4.
DR   InterPro; IPR008999; Actin-crosslinking.
DR   InterPro; IPR010431; Fascin.
DR   InterPro; IPR022768; Fascin-domain.
DR   InterPro; IPR024703; Fascin_metazoans.
DR   InterPro; IPR030146; FSCN1.
DR   PANTHER; PTHR10551; PTHR10551; 1.
DR   PANTHER; PTHR10551:SF23; PTHR10551:SF23; 1.
DR   Pfam; PF06268; Fascin; 3.
DR   PIRSF; PIRSF005682; Fascin; 1.
DR   SUPFAM; SSF50405; SSF50405; 4.
PE   1: Evidence at protein level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..496
FT                   /note="Fascin"
FT                   /id="PRO_0000219385"
SQ   SEQUENCE   496 AA;  54944 MW;  FF12FCE8C08B311B CRC64;
     MPAMNLKYKF GLVNSAGRYL TAEKFGGKVN ASGATLKARQ VWILEQEESS TISYLKAPSG
     NFLSADKNGN VYCSVEDRTE DADTGFEIEL QPDGKWALKN VSHQRYLACN GEELICSESS
     TSNPSANWTV QLAIHPQVCM KNVQHQRYAH LKTSEEGEDS VVVDELVPWG ADSTLTLVYL
     GKGKYGLEAF NGKFVQTDGQ LAGTANEQTQ FTLIFTSGHL VLRDNNGRHL GVDSGTRVLK
     SSKPGLTKAN YFILEDSCPQ GAFEFGGKYA SLKQGEDVSF KLLVDEDIED TETFQLEFVE
     TDKYAIRVCD PKKNSRDAKF WKTVAAGIQA NGNSKDQTDC QFSVEYNGND MHVRAPGGKY
     VSVRDNGHLF LQDSPKDFIF RLLNRPKLVL KCPHGFVGMK EGKAEVACNR SNFDVFTVTY
     KEGGYTIQDS CGKYWSCDDS SRIVLGEAAG TFFFEFHELS KFAIRAESNG MLIKGEQSGL
     FTANGSEVSK DTLWEF