AIDA_DANRE
ID AIDA_DANRE Reviewed; 303 AA.
AC Q6PBN2;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Axin interactor, dorsalization-associated protein;
DE AltName: Full=Axin interaction partner and dorsalization antagonist;
GN Name=aida; ORFNames=zgc:73327;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney marrow;
RX PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA Look A.T., Chen Z.;
RT "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Retina;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=17681137; DOI=10.1016/j.devcel.2007.07.006;
RA Rui Y., Xu Z., Xiong B., Cao Y., Lin S., Zhang M., Chan S.-C., Luo W.,
RA Han Y., Lu Z., Ye Z., Zhou H.-M., Han J., Meng A., Lin S.-C.;
RT "A beta-catenin-independent dorsalization pathway activated by Axin/JNK
RT signaling and antagonized by aida.";
RL Dev. Cell 13:268-282(2007).
CC -!- FUNCTION: Acts as a ventralizing factor during embryogenesis. Inhibits
CC axin-mediated JNK activation by binding axin and disrupting axin
CC homodimerization. This in turn antagonizes a Wnt/beta-catenin-
CC independent dorsalization pathway activated by axin/JNK-signaling.
CC {ECO:0000269|PubMed:17681137}.
CC -!- TISSUE SPECIFICITY: At 24 hours post-fertilization, expressed in most
CC tissues, with strongest expression in the brain and somites.
CC {ECO:0000269|PubMed:17681137}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC {ECO:0000269|PubMed:17681137}.
CC -!- SIMILARITY: Belongs to the AIDA family. {ECO:0000255|PROSITE-
CC ProRule:PRU01259, ECO:0000305}.
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DR EMBL; AY398347; AAQ97780.1; -; mRNA.
DR EMBL; BX936461; CAM56324.1; -; Genomic_DNA.
DR EMBL; BC059647; AAH59647.1; -; mRNA.
DR RefSeq; NP_957084.1; NM_200790.1.
DR PDB; 2QZQ; X-ray; 1.90 A; A=151-302.
DR PDBsum; 2QZQ; -.
DR AlphaFoldDB; Q6PBN2; -.
DR SMR; Q6PBN2; -.
DR STRING; 7955.ENSDARP00000026849; -.
DR PaxDb; Q6PBN2; -.
DR PRIDE; Q6PBN2; -.
DR Ensembl; ENSDART00000010271; ENSDARP00000026849; ENSDARG00000014532.
DR GeneID; 393763; -.
DR KEGG; dre:393763; -.
DR CTD; 64853; -.
DR ZFIN; ZDB-GENE-071126-2; aida.
DR eggNOG; ENOG502QSD5; Eukaryota.
DR GeneTree; ENSGT00390000016465; -.
DR HOGENOM; CLU_064322_0_0_1; -.
DR InParanoid; Q6PBN2; -.
DR OMA; KLHAAWC; -.
DR OrthoDB; 1196787at2759; -.
DR PhylomeDB; Q6PBN2; -.
DR TreeFam; TF328541; -.
DR EvolutionaryTrace; Q6PBN2; -.
DR PRO; PR:Q6PBN2; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 20.
DR Bgee; ENSDARG00000014532; Expressed in early embryo and 22 other tissues.
DR GO; GO:0016020; C:membrane; IDA:ZFIN.
DR GO; GO:0035091; F:phosphatidylinositol binding; IDA:ZFIN.
DR GO; GO:0048264; P:determination of ventral identity; IDA:MGI.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IDA:MGI.
DR GO; GO:2000016; P:negative regulation of determination of dorsal identity; IDA:MGI.
DR GO; GO:0046329; P:negative regulation of JNK cascade; IDA:MGI.
DR GO; GO:0043508; P:negative regulation of JUN kinase activity; IDA:MGI.
DR GO; GO:0031333; P:negative regulation of protein-containing complex assembly; ISS:UniProtKB.
DR Gene3D; 1.20.120.360; -; 1.
DR Gene3D; 2.60.40.150; -; 1.
DR InterPro; IPR025939; Aida_C.
DR InterPro; IPR023421; AIDA_N.
DR InterPro; IPR036818; AIDA_N_sf.
DR InterPro; IPR035892; C2_domain_sf.
DR Pfam; PF14186; Aida_C2; 1.
DR Pfam; PF08910; Aida_N; 1.
DR SUPFAM; SSF109779; SSF109779; 1.
DR PROSITE; PS51911; C2_AIDA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Coiled coil; Developmental protein; Reference proteome.
FT CHAIN 1..303
FT /note="Axin interactor, dorsalization-associated protein"
FT /id="PRO_0000305281"
FT DOMAIN 154..301
FT /note="C2 Aida-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01259"
FT REGION 133..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..218
FT /note="Axin-binding"
FT /evidence="ECO:0000250"
FT COILED 25..51
FT /evidence="ECO:0000255"
FT STRAND 165..174
FT /evidence="ECO:0007829|PDB:2QZQ"
FT HELIX 178..180
FT /evidence="ECO:0007829|PDB:2QZQ"
FT STRAND 182..191
FT /evidence="ECO:0007829|PDB:2QZQ"
FT STRAND 197..199
FT /evidence="ECO:0007829|PDB:2QZQ"
FT STRAND 212..222
FT /evidence="ECO:0007829|PDB:2QZQ"
FT HELIX 227..229
FT /evidence="ECO:0007829|PDB:2QZQ"
FT STRAND 235..243
FT /evidence="ECO:0007829|PDB:2QZQ"
FT TURN 245..247
FT /evidence="ECO:0007829|PDB:2QZQ"
FT STRAND 249..259
FT /evidence="ECO:0007829|PDB:2QZQ"
FT HELIX 260..262
FT /evidence="ECO:0007829|PDB:2QZQ"
FT STRAND 265..270
FT /evidence="ECO:0007829|PDB:2QZQ"
FT STRAND 273..276
FT /evidence="ECO:0007829|PDB:2QZQ"
FT STRAND 289..291
FT /evidence="ECO:0007829|PDB:2QZQ"
FT STRAND 294..301
FT /evidence="ECO:0007829|PDB:2QZQ"
SQ SEQUENCE 303 AA; 34560 MW; 40C9336436CE04FD CRC64;
MSDVNKTVQK WHASFKKGTD FDSWGQLVEA IDEYQILARQ LQKEVQSSNS HDFTEEQKKT
LGKFATCLEM RSAALQCTQS QEEFKLEDLK KLEPIIKNIL TYNKDFPFDV QPVPLRKILA
PGEEENLDVE EDLDAGTGAG STPSFTSRLP GSLLPRLPSE PGMTLLTLTI EKIGLKDAGQ
CIDPYITVSV KDLNGIDLNP VQDTPVATRK EDTYIHFSVD VEIQRHLEKL PKGAAIFFEF
KHYKPKKRFT STKCFAFMEM DEIKPGPIVI ELYKKPTDFK RKKLNLLTKK PLYLHLNQTL
HKD
