F120B_MOUSE
ID F120B_MOUSE Reviewed; 786 AA.
AC Q6RI63; Q5DTU5; Q8BK59; Q8BVH5; Q8BWQ3; Q8C158; Q99LL4; Q9DAC3;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Constitutive coactivator of peroxisome proliferator-activated receptor gamma;
DE Short=Constitutive coactivator of PPAR-gamma;
DE Short=Constitutive coactivator of PPARG;
DE AltName: Full=Protein FAM120B;
GN Name=Fam120b; Synonyms=Ccpg, Kiaa1838;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH ESR1;
RP PPARG AND RXRA, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL
RP STAGE, AND INDUCTION.
RC TISSUE=Lung;
RX PubMed=17595322; DOI=10.1210/me.2006-0520;
RA Li D., Kang Q., Wang D.-M.;
RT "Constitutive coactivator of peroxisome proliferator-activated receptor
RT (PPARgamma), a novel coactivator of PPARgamma that promotes adipogenesis.";
RL Mol. Endocrinol. 21:2320-2333(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Embryo, Liver, Olfactory bulb, Skin, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RA Nagaraja R., Waeltz P., Brathwaite M.E.;
RT "Genomic sequence analysis in the mouse T-complex region.";
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 255-786 (ISOFORM 1).
RC STRAIN=C57BL/6J, and Czech II; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Functions as a transactivator of PPARG and ESR1. Functions in
CC adipogenesis through PPARG activation. {ECO:0000269|PubMed:17595322}.
CC -!- SUBUNIT: Interacts with ESR1 and RXRA. Interacts with PPARG; in a
CC ligand-independent manner. {ECO:0000269|PubMed:17595322}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17595322}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6RI63-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6RI63-2; Sequence=VSP_033417, VSP_033418;
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed (at protein level).
CC {ECO:0000269|PubMed:17595322}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout the embryonic developmental
CC stages from 5 dpc to 19 dpc (at protein level).
CC {ECO:0000269|PubMed:17595322}.
CC -!- INDUCTION: Up-regulated in differentiating adipocytes (at protein
CC level). {ECO:0000269|PubMed:17595322}.
CC -!- SIMILARITY: Belongs to the constitutive coactivator of PPAR-gamma
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH03200.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB24339.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAD90470.1; Type=Erroneous translation; Evidence={ECO:0000305};
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DR EMBL; DQ873694; ABH09085.1; -; mRNA.
DR EMBL; AK005957; BAB24339.1; ALT_INIT; mRNA.
DR EMBL; AK028911; BAC26191.1; -; mRNA.
DR EMBL; AK050319; BAC34186.1; -; mRNA.
DR EMBL; AK076185; BAC36239.1; -; mRNA.
DR EMBL; AK078215; BAC37177.1; -; mRNA.
DR EMBL; AK132211; BAE21035.1; -; mRNA.
DR EMBL; AK220425; BAD90470.1; ALT_SEQ; Transcribed_RNA.
DR EMBL; AY497019; AAR30868.1; -; Genomic_DNA.
DR EMBL; BC003200; AAH03200.1; ALT_INIT; mRNA.
DR EMBL; BC085163; AAH85163.1; -; mRNA.
DR CCDS; CCDS37453.1; -. [Q6RI63-1]
DR RefSeq; NP_077165.2; NM_024203.3. [Q6RI63-1]
DR RefSeq; XP_006524890.1; XM_006524827.3.
DR AlphaFoldDB; Q6RI63; -.
DR BioGRID; 212265; 2.
DR STRING; 10090.ENSMUSP00000054420; -.
DR iPTMnet; Q6RI63; -.
DR PhosphoSitePlus; Q6RI63; -.
DR EPD; Q6RI63; -.
DR MaxQB; Q6RI63; -.
DR PaxDb; Q6RI63; -.
DR PeptideAtlas; Q6RI63; -.
DR PRIDE; Q6RI63; -.
DR ProteomicsDB; 275495; -. [Q6RI63-1]
DR ProteomicsDB; 275496; -. [Q6RI63-2]
DR Antibodypedia; 33580; 91 antibodies from 23 providers.
DR Ensembl; ENSMUST00000055352; ENSMUSP00000054420; ENSMUSG00000014763. [Q6RI63-1]
DR GeneID; 67544; -.
DR KEGG; mmu:67544; -.
DR UCSC; uc008aoj.2; mouse. [Q6RI63-1]
DR CTD; 84498; -.
DR MGI; MGI:1914794; Fam120b.
DR VEuPathDB; HostDB:ENSMUSG00000014763; -.
DR eggNOG; ENOG502QRMW; Eukaryota.
DR GeneTree; ENSGT00530000063168; -.
DR HOGENOM; CLU_007639_0_0_1; -.
DR InParanoid; Q6RI63; -.
DR OMA; TCPHVCT; -.
DR OrthoDB; 203269at2759; -.
DR PhylomeDB; Q6RI63; -.
DR TreeFam; TF331093; -.
DR BioGRID-ORCS; 67544; 5 hits in 71 CRISPR screens.
DR ChiTaRS; Fam120b; mouse.
DR PRO; PR:Q6RI63; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q6RI63; protein.
DR Bgee; ENSMUSG00000014763; Expressed in substantia nigra and 242 other tissues.
DR Genevisible; Q6RI63; MM.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0045444; P:fat cell differentiation; IMP:MGI.
DR GO; GO:0035357; P:peroxisome proliferator activated receptor signaling pathway; IPI:MGI.
DR InterPro; IPR026784; Coact_PPARg.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR PANTHER; PTHR15976; PTHR15976; 1.
DR SUPFAM; SSF88723; SSF88723; 1.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; Differentiation; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..786
FT /note="Constitutive coactivator of peroxisome proliferator-
FT activated receptor gamma"
FT /id="PRO_0000332991"
FT REGION 1..561
FT /note="Mediates transactivation of PPARG"
FT REGION 371..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 457..493
FT /note="VARMHHVHSESYLVYNILSSGEIECSNTLEDELDQAL -> ASDCASPTSVH
FT NVVIESVPTNGFDREKRTVGGCRRETS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072, ECO:0000303|Ref.3"
FT /id="VSP_033417"
FT VAR_SEQ 494..786
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072, ECO:0000303|Ref.3"
FT /id="VSP_033418"
FT CONFLICT 41
FT /note="I -> N (in Ref. 2; BAC36239)"
FT /evidence="ECO:0000305"
FT CONFLICT 178
FT /note="E -> K (in Ref. 2; BAC34186)"
FT /evidence="ECO:0000305"
FT CONFLICT 549
FT /note="V -> I (in Ref. 5; AAH03200)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 786 AA; 89313 MW; A9B6EEFD99275D4C CRC64;
MGVRGLQGFV GSTCPHICTI VNIHELAERH RNKYPGCTPT IVVDAMCCLR YWYTAESWVC
GGQWREYYCA LRNFVAAFTS AGIKLIFFFD GMVEPGKRDE WVKRRLKNNR EISKIFHYIK
SKRDQPGRNM FFIPSGLAIF TRFALKTLGQ ETFCSLQEAD YEVASYGLQH NCLGILGEDT
DYLIYDTCPY FSIGDLCLES LQTIMLCREK LCESLGLRVA DLPLLACLLG NDITPESMFE
SFRYKCLSSY ASVKENAGKK GNIILAVSDY ISKVLHLYQG EKKIEEMLPL GPNKALFYKG
VTSYLLPGQK SPWLVQKPKG MITDKQQMVS LNPESKQEVP MCIDPEFKQE VPVCTNPESM
QEVPMCMDPE PNQEASMCTD PESKQEVPMC TDSESKPEVS QYTNPESKQK LPSGIDTEFN
LEALMCTHPE FKQEDVMDME PEIKQVTMVS ESEILKVARM HHVHSESYLV YNILSSGEIE
CSNTLEDELD QALPSQAFIY RPVRQRVYAL LLGDWKDGAS TGPVVKEWFV YPGNSLKHPD
LVRPLQMTVQ GGTPSLEVLW LSQEPAVQAQ RLDTLLACFN LSSSREELQA VESPLRALCC
LLIYLFVQVD TLSLEDLHAF IAQALCLQGK STSQLMHLQL DYINSRAVQL GSLLVRGLTT
LVLVNSACGF PWTTSEFMPW NVFDGKLFHQ KYLQSEKGYA VEVLLEQNRS WLTKFHNLKA
VVCKACSKEN RRIVGRTHWD SPYTGRQGRQ GYSSYRTDST HGHSGQSWRN QGSGGRQHER
NHWRRY
