ID   EZRA_STRS2              Reviewed;         574 AA.
AC   A4W2T8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Septation ring formation regulator EzrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN   Name=ezrA {ECO:0000255|HAMAP-Rule:MF_00728}; OrderedLocusNames=SSU98_1519;
OS   Streptococcus suis (strain 98HAH33).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=391296;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=98HAH33;
RX   PubMed=17375201; DOI=10.1371/journal.pone.0000315;
RA   Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X.,
RA   Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J.,
RA   Dong Y., Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F.,
RA   Yang R., Wang J., Yu J.;
RT   "A glimpse of streptococcal toxic shock syndrome from comparative genomics
RT   of S. suis 2 Chinese isolates.";
RL   PLoS ONE 2:E315-E315(2007).
CC   -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC       frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC       formation at polar sites. Interacts either with FtsZ or with one of its
CC       binding partners to promote depolymerization. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00728};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00728}.
CC       Note=Colocalized with FtsZ to the nascent septal site.
CC       {ECO:0000255|HAMAP-Rule:MF_00728}.
CC   -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
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DR   EMBL; CP000408; ABP92677.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4W2T8; -.
DR   SMR; A4W2T8; -.
DR   KEGG; ssv:SSU98_1519; -.
DR   HOGENOM; CLU_034079_2_0_9; -.
DR   OMA; FRSQNHI; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005940; C:septin ring; IEA:InterPro.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR   HAMAP; MF_00728; EzrA; 1.
DR   InterPro; IPR010379; EzrA.
DR   Pfam; PF06160; EzrA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Coiled coil; Membrane; Septation;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..574
FT                   /note="Septation ring formation regulator EzrA"
FT                   /id="PRO_1000045913"
FT   TOPO_DOM        1..7
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TRANSMEM        8..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TOPO_DOM        27..574
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          105..189
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
SQ   SEQUENCE   574 AA;  66448 MW;  7124337D7176B1BA CRC64;
     MPTGTIILIV SIVIILIIAY VACLIVRKRN DNLLVALEER KEELFNLPVN EEVETVKALH
     LIGQSQVSFR EWNQKWVDLS LNSFADIENH IFEAEGYNNA FRFVSAKNAI DSIDSQIDLI
     EEDIASIRQG LMELKEQEEK NSGRVKHALN LFDSLQEAVR ENPDSYGETL SELEKQLKNI
     EVEFSEFVML NSSGDPIEAS EILDKTEEHM IALNQIMDRI PSLIERVTKD FPEQLEDLES
     GYRKLVEQNY LFTEANIESQ FQNIRVSIRE NTALIVSFDL DAAEAENEGI QAKIDHLYKV
     FNREIEANKE AVKISKNLPK FLEHVVQNTQ LLDEESQRLN ATYLLADSKL SRINQLKARL
     ESIEIVVTES VEDIENPQVA YSILEERLDH SLASLKEIEE EQLVLADYLK SQELSENTAR
     KKATLYINKL HTLKRYMEKR NLPGIPAEFL TNFFRTSDHV EALIAELDYK RINIEVVNRM
     LENATYDMNQ LEELAYLIVQ NATLTEQLLQ YSNRYRSFDE SVQKAFNRSL SIFEKDFDYQ
     AAFEEISFAL ETVEPGVTER FVRSYEKTRE AIRY