ID   EZRA_STAA8              Reviewed;         564 AA.
AC   Q2FXK8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Septation ring formation regulator EzrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN   Name=ezrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN   OrderedLocusNames=SAOUHSC_01827;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
CC   -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC       frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC       formation at polar sites. Interacts either with FtsZ or with one of its
CC       binding partners to promote depolymerization. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00728};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00728}.
CC       Note=Colocalized with FtsZ to the nascent septal site.
CC       {ECO:0000255|HAMAP-Rule:MF_00728}.
CC   -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000253; ABD30895.1; -; Genomic_DNA.
DR   RefSeq; WP_000244857.1; NC_007795.1.
DR   RefSeq; YP_500332.1; NC_007795.1.
DR   AlphaFoldDB; Q2FXK8; -.
DR   SMR; Q2FXK8; -.
DR   STRING; 1280.SAXN108_1746; -.
DR   EnsemblBacteria; ABD30895; ABD30895; SAOUHSC_01827.
DR   GeneID; 3921777; -.
DR   KEGG; sao:SAOUHSC_01827; -.
DR   PATRIC; fig|93061.5.peg.1666; -.
DR   eggNOG; COG4477; Bacteria.
DR   HOGENOM; CLU_034079_1_0_9; -.
DR   OMA; FRSQNHI; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005940; C:septin ring; IEA:InterPro.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR   HAMAP; MF_00728; EzrA; 1.
DR   InterPro; IPR010379; EzrA.
DR   Pfam; PF06160; EzrA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Coiled coil; Membrane;
KW   Reference proteome; Septation; Transmembrane; Transmembrane helix.
FT   CHAIN           1..564
FT                   /note="Septation ring formation regulator EzrA"
FT                   /id="PRO_1000045903"
FT   TOPO_DOM        1..4
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TRANSMEM        5..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TOPO_DOM        24..564
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          99..138
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          190..223
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          271..300
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          350..435
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          471..550
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
SQ   SEQUENCE   564 AA;  66247 MW;  DFE47B81AE97023E CRC64;
     MVLYIILAII VIILIAVGVL FYLRSNKRQI IEKAIERKNE IETLPFDQNL AQLFKLNLKG
     ETKTKYDAMK KDTVESTNKY LAPVEEKIHN AEALLDKFSF NASQSEIDDA NELMDSYEQS
     YQQQLEDVNE IIALYKDNDE LYDKCKVDYR EMKRDVLANR HQFGEAASLL ETEIEKFEPR
     LEQYEVLKAD GNYVQAHNHI AALNEQMKQL RSYMEEIPEL IRETQKELPG QFQDLKYGCR
     DLKVEGYDLD HVKVDSTLQS LKTELSFVEP LISRLELEEA NDKLANINDK LDDMYDLIEH
     EVKAKNDVEE TKDIITDNLF KAKDMNYTLQ TEIEYVRENY YINESDAQSV RQFENEIQSL
     ISVYDDILKE MSKSAVRYSE VQDNLQYLED HVTVINDKQE KLQNHLIQLR EDEAEAEDNL
     LRVQSKKEEV YRRLLASNLT SVPERFIIMK NEIDHEVRDV NEQFSERPIH VKQLKDKVSK
     IVIQMNTFED EANDVLVNAV YAEKLIQYGN RYRKDYSNVD KSLNEAERLF KNNRYKRAIE
     IAEQALESVE PGVTKHIEEE VIKQ