ID   EZRA_OCEIH              Reviewed;         564 AA.
AC   Q8EPB2;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Septation ring formation regulator EzrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN   Name=ezrA {ECO:0000255|HAMAP-Rule:MF_00728}; OrderedLocusNames=OB2200;
OS   Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC
OS   3954 / HTE831).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX   NCBI_TaxID=221109;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831;
RX   PubMed=12235376; DOI=10.1093/nar/gkf526;
RA   Takami H., Takaki Y., Uchiyama I.;
RT   "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge
RT   and its unexpected adaptive capabilities to extreme environments.";
RL   Nucleic Acids Res. 30:3927-3935(2002).
CC   -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC       frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC       formation at polar sites. Interacts either with FtsZ or with one of its
CC       binding partners to promote depolymerization. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein.
CC       Note=Colocalized with FtsZ to the nascent septal site.
CC       {ECO:0000255|HAMAP-Rule:MF_00728}.
CC   -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
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DR   EMBL; BA000028; BAC14156.1; -; Genomic_DNA.
DR   RefSeq; WP_011066594.1; NC_004193.1.
DR   AlphaFoldDB; Q8EPB2; -.
DR   SMR; Q8EPB2; -.
DR   STRING; 221109.22777885; -.
DR   EnsemblBacteria; BAC14156; BAC14156; BAC14156.
DR   KEGG; oih:OB2200; -.
DR   eggNOG; COG4477; Bacteria.
DR   HOGENOM; CLU_034079_1_0_9; -.
DR   OMA; FRSQNHI; -.
DR   OrthoDB; 670472at2; -.
DR   PhylomeDB; Q8EPB2; -.
DR   Proteomes; UP000000822; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005940; C:septin ring; IEA:InterPro.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR   HAMAP; MF_00728; EzrA; 1.
DR   InterPro; IPR010379; EzrA.
DR   Pfam; PF06160; EzrA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Coiled coil; Membrane;
KW   Reference proteome; Septation; Transmembrane; Transmembrane helix.
FT   CHAIN           1..564
FT                   /note="Septation ring formation regulator EzrA"
FT                   /id="PRO_0000172877"
FT   TOPO_DOM        1..2
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TRANSMEM        3..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TOPO_DOM        22..564
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          101..140
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          168..215
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          251..436
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          468..537
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
SQ   SEQUENCE   564 AA;  66433 MW;  11ABC8FBA16FF3FE CRC64;
     MVFVISVILA IIVILTIGLI LRKRIYDKVD HQEKWKMDIM ARDVAQQISK IKSLNLSGET
     QEKFELWKGR WEHIITKELP DIEDHLFDAE DAADKFRMKR ANNILTEGDQ KLQNIEVKIE
     EILEELDELL SSEKTSREEV AQIVPTIKLL RKTLSQSRYQ YGKAEKFFDK KLDEFDTQLA
     TYEDNVESGD YLEANRLIQV LKEEIAEFEI KMEQFPEILR RCKQDLPSQL EQVLAGLQEM
     KNDGYRVKHF GFDKEIITYQ DQLKNLQQQI EQGDITDVST KLDEIEERIT EMYESLEGEA
     IAKNYLEQRI PEYEKSISEI AATYDDTKLE VEELQKAYFV ENNDMERFFT IGKTISTLRE
     QLKELHKEMD DDQKSHSDLQ NIVEDGFDKI EQLEEQHEEF KKSIENLRKD EMEAREKLIE
     MRRQLYELNR KIKKSNIPGV PGFIWTRFET ASAKNSQVVD VLEDYPLDIA KVQHALSEAK
     QAVDQTHEQI DIMLDQAYLT EQVIQYANRY RSQQPDLNGK LKEAERLFRN YEYELSLEHA
     AKAIEEIEPG ALKRIEENQL TLNR