ID   EZRA_LISW6              Reviewed;         571 AA.
AC   A0AJ43;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Septation ring formation regulator EzrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN   Name=ezrA {ECO:0000255|HAMAP-Rule:MF_00728}; OrderedLocusNames=lwe1607;
OS   Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 /
OS   NCTC 11857 / SLCC 5334 / V8).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=386043;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8;
RX   PubMed=16936040; DOI=10.1128/jb.00758-06;
RA   Hain T., Steinweg C., Kuenne C.T., Billion A., Ghai R., Chatterjee S.S.,
RA   Domann E., Kaerst U., Goesmann A., Bekel T., Bartels D., Kaiser O.,
RA   Meyer F., Puehler A., Weisshaar B., Wehland J., Liang C., Dandekar T.,
RA   Lampidis R., Kreft J., Goebel W., Chakraborty T.;
RT   "Whole-genome sequence of Listeria welshimeri reveals common steps in
RT   genome reduction with Listeria innocua as compared to Listeria
RT   monocytogenes.";
RL   J. Bacteriol. 188:7405-7415(2006).
CC   -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC       frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC       formation at polar sites. Interacts either with FtsZ or with one of its
CC       binding partners to promote depolymerization. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00728};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00728}.
CC       Note=Colocalized with FtsZ to the nascent septal site.
CC       {ECO:0000255|HAMAP-Rule:MF_00728}.
CC   -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
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DR   EMBL; AM263198; CAK21025.1; -; Genomic_DNA.
DR   RefSeq; WP_011702392.1; NC_008555.1.
DR   AlphaFoldDB; A0AJ43; -.
DR   SMR; A0AJ43; -.
DR   STRING; 386043.lwe1607; -.
DR   EnsemblBacteria; CAK21025; CAK21025; lwe1607.
DR   GeneID; 61189484; -.
DR   KEGG; lwe:lwe1607; -.
DR   eggNOG; COG4477; Bacteria.
DR   HOGENOM; CLU_034079_2_0_9; -.
DR   OMA; FRSQNHI; -.
DR   OrthoDB; 670472at2; -.
DR   Proteomes; UP000000779; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005940; C:septin ring; IEA:InterPro.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR   HAMAP; MF_00728; EzrA; 1.
DR   InterPro; IPR010379; EzrA.
DR   Pfam; PF06160; EzrA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Coiled coil; Membrane; Septation;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..571
FT                   /note="Septation ring formation regulator EzrA"
FT                   /id="PRO_1000045900"
FT   TOPO_DOM        1..3
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TRANSMEM        4..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TOPO_DOM        23..571
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          169..214
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          249..298
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          326..374
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          400..438
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          474..529
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
SQ   SEQUENCE   571 AA;  66796 MW;  35B814BFD8981305 CRC64;
     MYYMLIGFII VVIAIISAGY ILKRKHYQRI NELEETKIKL RERPVIDELS KVKKLKLTGQ
     TEALFESWRS SWDEIETRLF PDLEEVLLEA EMNTDRYKFR SATYVENDIE QMLVVIEKQM
     DQILGGLKEL LISEEKNAKE SRMTKEKFAE LRREVLTRGF KLGDTLPYVE TKLDELAENL
     NRYDLLTDQG DHLEAREIVL IVQKEMKVIE AQMERIPSLL HETDTILPEE MNKLRAGYEE
     MVRKGYYLAQ MELDKEITRM KTQIDKMKRN VINLDLDEAE QGIEELHNEI DLFYDTLEHE
     AEARHFVKEN HSPTSDKLQR QNTVSDALAE QITEVKQTYH VAEDDLAVYL KTSAKLSEAK
     ENFEQLTALI ASGEIAYSAA QDTLKEIDAA LISIGAEQDK FAEELRSLRK DELEARDDAE
     RMRRAIVTLD RKMERERLPG LPEEYLSLRE HMGESIDALE KRLEEKPLNM KAVTQDWRIA
     EEDLNHLTEK AEEMMENVRL VEHVIQYANR YRLRNKELAD ELVQAENHFY NDYQYKKALE
     IAVTALEKVE TGAFKKVEKA YESKVSVDDI E