ID   EZRA_LISIN              Reviewed;         571 AA.
AC   Q92BB4;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Septation ring formation regulator EzrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN   Name=ezrA {ECO:0000255|HAMAP-Rule:MF_00728}; OrderedLocusNames=lin1636;
OS   Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=272626;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-680 / CLIP 11262;
RX   PubMed=11679669; DOI=10.1126/science.1063447;
RA   Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA   Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA   Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA   Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA   Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA   Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA   Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA   Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA   Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA   Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT   "Comparative genomics of Listeria species.";
RL   Science 294:849-852(2001).
CC   -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC       frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC       formation at polar sites. Interacts either with FtsZ or with one of its
CC       binding partners to promote depolymerization. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein.
CC       Note=Colocalized with FtsZ to the nascent septal site.
CC       {ECO:0000255|HAMAP-Rule:MF_00728}.
CC   -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
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DR   EMBL; AL596169; CAC96867.1; -; Genomic_DNA.
DR   PIR; AC1637; AC1637.
DR   RefSeq; WP_010991625.1; NC_003212.1.
DR   AlphaFoldDB; Q92BB4; -.
DR   SMR; Q92BB4; -.
DR   STRING; 272626.lin1636; -.
DR   PRIDE; Q92BB4; -.
DR   EnsemblBacteria; CAC96867; CAC96867; CAC96867.
DR   KEGG; lin:lin1636; -.
DR   eggNOG; COG4477; Bacteria.
DR   HOGENOM; CLU_034079_1_0_9; -.
DR   OMA; FRSQNHI; -.
DR   OrthoDB; 670472at2; -.
DR   Proteomes; UP000002513; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005940; C:septin ring; IEA:InterPro.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR   HAMAP; MF_00728; EzrA; 1.
DR   InterPro; IPR010379; EzrA.
DR   Pfam; PF06160; EzrA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Coiled coil; Membrane; Septation;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..571
FT                   /note="Septation ring formation regulator EzrA"
FT                   /id="PRO_0000172874"
FT   TOPO_DOM        1..3
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TRANSMEM        4..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TOPO_DOM        23..571
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          170..215
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          248..299
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          326..374
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          400..437
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          478..529
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
SQ   SEQUENCE   571 AA;  66526 MW;  C3F2E6079AB58B96 CRC64;
     MYYMLIGFII VVIAVISAGY ILKRKHYQRI NELEETKIKL RERPVIDELS KVKKLKLTGQ
     TEALFESWRS SWDEIETRLF PDLEEVLLEA EMNADRYRFR SATNTENDIE QMLVVIEKQM
     DQILGGLKEL LISEEKNAKE SRMTKEKFAE LRREVLTRGF KLGETLPYVE AKLNSLAENL
     NRYDSLTDQA DHLEAREIVI SVQKEMAVIE AQMERIPSLL HETDTILPEE MNKLRAGYEE
     MVRKGYYLAQ MELDKEISRM KTQIEKMKQN VINLDLDEAE EGIEELHNEI ELFYDTLEHE
     AEARHFVKEN HSPTSDKLKR QNTVSDALAE QITEVKQTYH VAEDDLAVYL KTSAKLSEAK
     ENFEQLTALI ASGEIAYSAA QDTLKEIDAA LLSISSEQDN FAEELRSLRK DELEARDDAE
     RMRRAIITLD RKMERERLPG LPEEYLSLRA HMGESIDALE KRLEEKPLNM KAVSQDWRIA
     EEDLTHLTEK AEEMMENVRL VEHVIQYANR YRLRNKELAD ELVQAENHFY NDYQYKKALE
     IAVTALEKVE TGAFKKVEKA YESKVSVDDI E