ID   EX7L_HELPY              Reviewed;         420 AA.
AC   O25039;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=HP_0259;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
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DR   EMBL; AE000511; AAD07327.1; -; Genomic_DNA.
DR   PIR; C64552; C64552.
DR   RefSeq; NP_207057.1; NC_000915.1.
DR   RefSeq; WP_000382848.1; NC_018939.1.
DR   AlphaFoldDB; O25039; -.
DR   DIP; DIP-3158N; -.
DR   IntAct; O25039; 2.
DR   MINT; O25039; -.
DR   STRING; 85962.C694_01310; -.
DR   PaxDb; O25039; -.
DR   EnsemblBacteria; AAD07327; AAD07327; HP_0259.
DR   KEGG; hpy:HP_0259; -.
DR   PATRIC; fig|85962.47.peg.279; -.
DR   eggNOG; COG1570; Bacteria.
DR   OMA; WPAVRFE; -.
DR   PhylomeDB; O25039; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..420
FT                   /note="Exodeoxyribonuclease 7 large subunit"
FT                   /id="PRO_0000197850"
SQ   SEQUENCE   420 AA;  47170 MW;  D704819640F480EA CRC64;
     MDVLSVSEIN AQIKALLEAT FLQVRVQGEV SNLTIHKVSG HAYFSLKDSQ SVIKCVLFKG
     NANRLKFALK EGQEVVVFGG ISVYVPRGDY QINCFEIEPK DIGSLTLALE QLKEKLRLKG
     YFDEENKLPK PHFPKRVAVI TSQNSAAWAD MKKIASKRWP MCELVCINTL MQGEGCVQSV
     VESIVYADSF HDTKNAFDAI VVARGGGSME DLYSFNDEKI ADALYLAKTF SMSAIGHESD
     FLLSDLVADL RASTPSNAME ILLPSSDEWL QRLDGFNVKL HRSFKTLLHQ KKAHLEHLVA
     SLKRLSFENK HHLNALKLEK LKIALENKTL EFLRFKKTLL EKISTQTLTS PFLQTKTERL
     NRLENALKLA HANLKLPQFG ALVSKNNQAI ELEALKRGDK IELSNEKTRA SAEILSVDRV