AGRG7_HUMAN
ID AGRG7_HUMAN Reviewed; 797 AA.
AC Q96K78; Q14D94; Q86SQ2;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Adhesion G-protein coupled receptor G7 {ECO:0000303|PubMed:25713288};
DE AltName: Full=G-protein coupled receptor 128;
DE Flags: Precursor;
GN Name=ADGRG7; Synonyms=GPR128;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12565841; DOI=10.1016/s0006-291x(03)00026-3;
RA Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C.,
RA Schioeth H.B.;
RT "There exist at least 30 human G-protein-coupled receptors with long
RT Ser/Thr-rich N-termini.";
RL Biochem. Biophys. Res. Commun. 301:725-734(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLU-151.
RC TISSUE=Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NOMENCLATURE.
RX PubMed=25713288; DOI=10.1124/pr.114.009647;
RA Hamann J., Aust G., Arac D., Engel F.B., Formstone C., Fredriksson R.,
RA Hall R.A., Harty B.L., Kirchhoff C., Knapp B., Krishnan A., Liebscher I.,
RA Lin H.H., Martinelli D.C., Monk K.R., Peeters M.C., Piao X., Promel S.,
RA Schoneberg T., Schwartz T.W., Singer K., Stacey M., Ushkaryov Y.A.,
RA Vallon M., Wolfrum U., Wright M.W., Xu L., Langenhan T., Schioth H.B.;
RT "International union of basic and clinical pharmacology. XCIV. Adhesion G
RT protein-coupled receptors.";
RL Pharmacol. Rev. 67:338-367(2015).
CC -!- FUNCTION: Orphan receptor.
CC -!- INTERACTION:
CC Q96K78; Q5T700: LDLRAD1; NbExp=7; IntAct=EBI-10290200, EBI-10173166;
CC Q96K78; Q99523: SORT1; NbExp=3; IntAct=EBI-10290200, EBI-1057058;
CC Q96K78; Q9P0L0: VAPA; NbExp=3; IntAct=EBI-10290200, EBI-1059156;
CC Q96K78; A8KA83; NbExp=3; IntAct=EBI-10290200, EBI-10174961;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO27358.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY181246; AAO27358.1; ALT_INIT; mRNA.
DR EMBL; AK027360; BAB55061.1; -; mRNA.
DR EMBL; CH471052; EAW79818.1; -; Genomic_DNA.
DR EMBL; BC113451; AAI13452.1; -; mRNA.
DR CCDS; CCDS2938.1; -.
DR RefSeq; NP_116176.2; NM_032787.2.
DR AlphaFoldDB; Q96K78; -.
DR SMR; Q96K78; -.
DR BioGRID; 124318; 4.
DR IntAct; Q96K78; 4.
DR STRING; 9606.ENSP00000273352; -.
DR MEROPS; P02.020; -.
DR GlyGen; Q96K78; 10 sites.
DR iPTMnet; Q96K78; -.
DR PhosphoSitePlus; Q96K78; -.
DR BioMuta; ADGRG7; -.
DR DMDM; 229462926; -.
DR MassIVE; Q96K78; -.
DR PaxDb; Q96K78; -.
DR PeptideAtlas; Q96K78; -.
DR PRIDE; Q96K78; -.
DR ProteomicsDB; 77050; -.
DR Antibodypedia; 15851; 109 antibodies from 24 providers.
DR DNASU; 84873; -.
DR Ensembl; ENST00000273352.8; ENSP00000273352.3; ENSG00000144820.8.
DR GeneID; 84873; -.
DR KEGG; hsa:84873; -.
DR MANE-Select; ENST00000273352.8; ENSP00000273352.3; NM_032787.3; NP_116176.2.
DR UCSC; uc003duc.5; human.
DR CTD; 84873; -.
DR DisGeNET; 84873; -.
DR GeneCards; ADGRG7; -.
DR HGNC; HGNC:19241; ADGRG7.
DR HPA; ENSG00000144820; Group enriched (intestine, liver).
DR MIM; 612307; gene.
DR neXtProt; NX_Q96K78; -.
DR OpenTargets; ENSG00000144820; -.
DR PharmGKB; PA134982718; -.
DR VEuPathDB; HostDB:ENSG00000144820; -.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000159169; -.
DR HOGENOM; CLU_370321_0_0_1; -.
DR InParanoid; Q96K78; -.
DR OMA; DLMKICQ; -.
DR OrthoDB; 349194at2759; -.
DR PhylomeDB; Q96K78; -.
DR TreeFam; TF351485; -.
DR PathwayCommons; Q96K78; -.
DR SignaLink; Q96K78; -.
DR BioGRID-ORCS; 84873; 9 hits in 1066 CRISPR screens.
DR ChiTaRS; ADGRG7; human.
DR GenomeRNAi; 84873; -.
DR Pharos; Q96K78; Tbio.
DR PRO; PR:Q96K78; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q96K78; protein.
DR Bgee; ENSG00000144820; Expressed in jejunal mucosa and 97 other tissues.
DR ExpressionAtlas; Q96K78; baseline and differential.
DR Genevisible; Q96K78; HS.
DR GO; GO:0016021; C:integral component of membrane; TAS:GDB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:GDB.
DR Gene3D; 2.60.220.50; -; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 1: Evidence at protein level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..797
FT /note="Adhesion G-protein coupled receptor G7"
FT /id="PRO_0000012903"
FT TOPO_DOM 27..438
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 439..459
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 460..468
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 469..489
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 490..528
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 529..549
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 550..565
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 566..586
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 587..623
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 624..644
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 645..669
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 670..690
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 691..698
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 699..719
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 720..797
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 380..427
FT /note="GPS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00098"
FT CARBOHYD 82
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 178
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 191
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 247
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 261
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 312
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 316
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 387
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 413
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 151
FT /note="K -> E (in dbSNP:rs1144122)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_055138"
FT VARIANT 645
FT /note="T -> S (in dbSNP:rs16842529)"
FT /id="VAR_049459"
FT VARIANT 756
FT /note="R -> H (in dbSNP:rs9872512)"
FT /id="VAR_049460"
SQ SEQUENCE 797 AA; 88909 MW; D6CAAA78AC0E4679 CRC64;
MASCRAWNLR VLVAVVCGLL TGIILGLGIW RIVIRIQRGK STSSSSTPTE FCRNGGTWEN
GRCICTEEWK GLRCTIANFC ENSTYMGFTF ARIPVGRYGP SLQTCGKDTP NAGNPMAVRL
CSLSLYGEIE LQKVTIGNCN ENLETLEKQV KDVTAPLNNI SSEVQILTSD ANKLTAENIT
SATRVVGQIF NTSRNASPEA KKVAIVTVSQ LLDASEDAFQ RVAATANDDA LTTLIEQMET
YSLSLGNQSV VEPNIAIQSA NFSSENAVGP SNVRFSVQKG ASSSLVSSST FIHTNVDGLN
PDAQTELQVL LNMTKNYTKT CGFVVYQNDK LFQSKTFTAK SDFSQKIISS KTDENEQDQS
ASVDMVFSPK YNQKEFQLYS YACVYWNLSA KDWDTYGCQK DKGTDGFLRC RCNHTTNFAV
LMTFKKDYQY PKSLDILSNV GCALSVTGLA LTVIFQIVTR KVRKTSVTWV LVNLCISMLI
FNLLFVFGIE NSNKNLQTSD GDINNIDFDN NDIPRTDTIN IPNPMCTAIA ALLHYFLLVT
FTWNALSAAQ LYYLLIRTMK PLPRHFILFI SLIGWGVPAI VVAITVGVIY SQNGNNPQWE
LDYRQEKICW LAIPEPNGVI KSPLLWSFIV PVTIILISNV VMFITISIKV LWKNNQNLTS
TKKVSSMKKI VSTLSVAVVF GITWILAYLM LVNDDSIRIV FSYIFCLFNT TQGLQIFILY
TVRTKVFQSE ASKVLMLLSS IGRRKSLPSV TRPRLRVKMY NFLRSLPTLH ERFRLLETSP
STEEITLSES DNAKESI
