AGRG4_HUMAN
ID AGRG4_HUMAN Reviewed; 3080 AA.
AC Q8IZF6; A2A2J1; A2A2J2; Q5EGP2; Q86SM6;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Adhesion G-protein coupled receptor G4 {ECO:0000303|PubMed:25713288};
DE AltName: Full=G-protein coupled receptor 112;
DE Flags: Precursor;
GN Name=ADGRG4; Synonyms=GPR112;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=12435584; DOI=10.1016/s0014-5793(02)03574-3;
RA Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B.;
RT "Novel human G protein-coupled receptors with long N-terminals containing
RT GPS domains and Ser/Thr-rich regions.";
RL FEBS Lett. 531:407-414(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS MET-276 AND HIS-368.
RC TISSUE=Retina;
RA Bonner T.I., Kauffman D., Nagle J.W., Sloger M., Kozhich O.;
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 343-1613 (ISOFORMS 1/2).
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=18953328; DOI=10.1038/modpathol.2008.174;
RA Leja J., Essaghir A., Essand M., Wester K., Oeberg K., Toetterman T.H.,
RA Lloyd R., Vasmatzis G., Demoulin J.-B., Giandomenico V.;
RT "Novel markers for enterochromaffin cells and gastrointestinal
RT neuroendocrine carcinomas.";
RL Mod. Pathol. 22:261-272(2009).
RN [6]
RP NOMENCLATURE.
RX PubMed=25713288; DOI=10.1124/pr.114.009647;
RA Hamann J., Aust G., Arac D., Engel F.B., Formstone C., Fredriksson R.,
RA Hall R.A., Harty B.L., Kirchhoff C., Knapp B., Krishnan A., Liebscher I.,
RA Lin H.H., Martinelli D.C., Monk K.R., Peeters M.C., Piao X., Promel S.,
RA Schoneberg T., Schwartz T.W., Singer K., Stacey M., Ushkaryov Y.A.,
RA Vallon M., Wolfrum U., Wright M.W., Xu L., Langenhan T., Schioth H.B.;
RT "International union of basic and clinical pharmacology. XCIV. Adhesion G
RT protein-coupled receptors.";
RL Pharmacol. Rev. 67:338-367(2015).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8IZF6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IZF6-2; Sequence=VSP_038170, VSP_038173, VSP_038174,
CC VSP_038175, VSP_038176;
CC Name=3;
CC IsoId=Q8IZF6-3; Sequence=VSP_038171, VSP_038172;
CC -!- TISSUE SPECIFICITY: Detected in fetal retina. Highly expressed in
CC normal enterochromaffin cells and in neuroendocrine carcinoma. Detected
CC in normal liver; highly expressed in primary liver carcinoma.
CC {ECO:0000269|PubMed:18953328}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily. {ECO:0000305}.
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DR EMBL; AY140954; AAN46668.1; -; mRNA.
DR EMBL; AY882585; AAW78659.1; -; mRNA.
DR EMBL; AL078638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL136167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL161778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY255581; AAO85093.1; -; mRNA.
DR CCDS; CCDS35409.1; -. [Q8IZF6-1]
DR RefSeq; NP_722576.3; NM_153834.3. [Q8IZF6-1]
DR RefSeq; XP_011529571.1; XM_011531269.2. [Q8IZF6-1]
DR SMR; Q8IZF6; -.
DR BioGRID; 126563; 2.
DR IntAct; Q8IZF6; 2.
DR STRING; 9606.ENSP00000377699; -.
DR MEROPS; P02.014; -.
DR GlyGen; Q8IZF6; 8 sites.
DR iPTMnet; Q8IZF6; -.
DR PhosphoSitePlus; Q8IZF6; -.
DR BioMuta; ADGRG4; -.
DR DMDM; 259016241; -.
DR EPD; Q8IZF6; -.
DR jPOST; Q8IZF6; -.
DR MassIVE; Q8IZF6; -.
DR PaxDb; Q8IZF6; -.
DR PeptideAtlas; Q8IZF6; -.
DR PRIDE; Q8IZF6; -.
DR ProteomicsDB; 71345; -. [Q8IZF6-1]
DR ProteomicsDB; 71346; -. [Q8IZF6-2]
DR ProteomicsDB; 71347; -. [Q8IZF6-3]
DR Antibodypedia; 51733; 43 antibodies from 17 providers.
DR DNASU; 139378; -.
DR Ensembl; ENST00000370652.5; ENSP00000359686.1; ENSG00000156920.11. [Q8IZF6-1]
DR Ensembl; ENST00000394141.1; ENSP00000377697.1; ENSG00000156920.11. [Q8IZF6-3]
DR Ensembl; ENST00000394143.6; ENSP00000377699.1; ENSG00000156920.11. [Q8IZF6-1]
DR GeneID; 139378; -.
DR KEGG; hsa:139378; -.
DR MANE-Select; ENST00000394143.6; ENSP00000377699.1; NM_153834.4; NP_722576.3.
DR UCSC; uc004ezu.1; human. [Q8IZF6-1]
DR CTD; 139378; -.
DR GeneCards; ADGRG4; -.
DR HGNC; HGNC:18992; ADGRG4.
DR HPA; ENSG00000156920; Tissue enhanced (fallopian tube, intestine, retina).
DR neXtProt; NX_Q8IZF6; -.
DR OpenTargets; ENSG00000156920; -.
DR PharmGKB; PA134885132; -.
DR VEuPathDB; HostDB:ENSG00000156920; -.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000162744; -.
DR HOGENOM; CLU_000643_0_0_1; -.
DR InParanoid; Q8IZF6; -.
DR OMA; DFYGRAD; -.
DR OrthoDB; 148879at2759; -.
DR PhylomeDB; Q8IZF6; -.
DR TreeFam; TF321769; -.
DR PathwayCommons; Q8IZF6; -.
DR SignaLink; Q8IZF6; -.
DR BioGRID-ORCS; 139378; 22 hits in 704 CRISPR screens.
DR ChiTaRS; ADGRG4; human.
DR GeneWiki; GPR112; -.
DR GenomeRNAi; 139378; -.
DR Pharos; Q8IZF6; Tdark.
DR PRO; PR:Q8IZF6; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q8IZF6; protein.
DR Bgee; ENSG00000156920; Expressed in duodenum and 40 other tissues.
DR Genevisible; Q8IZF6; HS.
DR GO; GO:0016021; C:integral component of membrane; TAS:GDB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:GDB.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00354; Pentaxin; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Signal; Transducer;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..3080
FT /note="Adhesion G-protein coupled receptor G4"
FT /id="PRO_0000070335"
FT TOPO_DOM 28..2741
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 2742..2762
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 2763..2778
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 2779..2799
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 2800..2805
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 2806..2826
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 2827..2848
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 2849..2869
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 2870..2892
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 2893..2913
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 2914..2942
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 2943..2963
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 2964..2965
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 2966..2986
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 2987..3080
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT DOMAIN 29..228
FT /note="Pentraxin (PTX)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT DOMAIN 2682..2733
FT /note="GPS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00098"
FT REGION 946..965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1274..1348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2109..2141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3051..3080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3051..3065
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 233
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 487
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 836
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 899
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1020
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1519
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2361
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2640
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 58..123
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT VAR_SEQ 1..63
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12435584"
FT /id="VSP_038170"
FT VAR_SEQ 24
FT /note="D -> V (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_038171"
FT VAR_SEQ 25..229
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_038172"
FT VAR_SEQ 2243..2381
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12435584"
FT /id="VSP_038173"
FT VAR_SEQ 2593..2637
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12435584"
FT /id="VSP_038174"
FT VAR_SEQ 2979..3012
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12435584"
FT /id="VSP_038175"
FT VAR_SEQ 3069..3080
FT /note="DDFDKDPYCSSP -> APELSALHVVASEPTTG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12435584"
FT /id="VSP_038176"
FT VARIANT 276
FT /note="I -> M (in dbSNP:rs4829829)"
FT /evidence="ECO:0000269|Ref.2"
FT /id="VAR_055929"
FT VARIANT 368
FT /note="P -> H (in dbSNP:rs5930931)"
FT /evidence="ECO:0000269|Ref.2"
FT /id="VAR_059329"
FT VARIANT 1213
FT /note="T -> N (in dbSNP:rs4829830)"
FT /id="VAR_059330"
FT VARIANT 1540
FT /note="S -> P (in dbSNP:rs912002)"
FT /id="VAR_059331"
FT VARIANT 1791
FT /note="F -> L (in dbSNP:rs5930932)"
FT /id="VAR_059332"
FT CONFLICT 229
FT /note="Missing (in Ref. 1; AAN46668)"
FT /evidence="ECO:0000305"
FT CONFLICT 2426
FT /note="Missing (in Ref. 1; AAN46668)"
FT /evidence="ECO:0000305"
FT CONFLICT 2694
FT /note="Missing (in Ref. 1; AAN46668)"
FT /evidence="ECO:0000305"
FT CONFLICT 2769
FT /note="Missing (in Ref. 1; AAN46668)"
FT /evidence="ECO:0000305"
FT CONFLICT 2885
FT /note="Missing (in Ref. 1; AAN46668)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3080 AA; 333368 MW; 3449BC820B251BD3 CRC64;
MKEHIIYQKL YGLILMSSFI FLSDTLSLKG KKLDFFGRGD TYVSLIDTIP ELSRFTACID
LVFMDDNSRY WMAFSYITNN ALLGREDIDL GLAGDHQQLI LYRLGKTFSI RHHLASFQWH
TICLIWDGVK GKLELFLNKE RILEVTDQPH NLTPHGTLFL GHFLKNESSE VKSMMRSFPG
SLYYFQLWDH ILENEEFMKC LDGNIVSWEE DVWLVNKIIP TVDRTLRCFV PENMTIQEKS
TTVSQQIDMT TPSQITGVKP QNTAHSSTLL SQSIPIFATD YTTISYSNTT SPPLETMTAQ
KILKTLVDET ATFAVDVLST SSAISLPTQS ISIDNTTNSM KKTKSPSSES TKTTKMVEAM
ATEIFQPPTP SNFLSTSRFT KNSVVSTTSA IKSQSAVTKT TSLFSTIEST SMSTTPCLKQ
KSTNTGALPI STAGQEFIES TAAGTVPWFT VEKTSPASTH VGTASSFPPE PVLISTAAPV
DSVFPRNQTA FPLATTDMKI AFTVHSLTLP TRLIETTPAP RTAETELTST NFQDVSLPRV
EDAMSTSMSK ETSSKTFSFL TSFSFTGTES VQTVIDAEAT RTALTPEITL ASTVAETMLS
STITGRVYTQ NTPTADGHLL TLMSTRSAST SKAPESGPTS TTDEAAHLFS SNETIWTSRP
DQALLASMNT TTILTFVPNE NFTSAFHENT TYTEYLSATT NITPLKASPE GKGTTANDAT
TARYTTAVSK LTSPWFANFS IVSGTTSITN MPEFKLTTLL LKTIPMSTKP ANELPLTPRE
TVVPSVDIIS TLACIQPNFS TEESASETTQ TEINGAIVFG GTTTPVPKSA TTQRLNATVT
RKEATSHYLM RKSTIAAVAE VSPFSTMLEV TDESAQRVTA SVTVSSFPDI EKLSTPLDNK
TATTEVRESW LLTKLVKTTP RSSYNEMTEM FNFNHTYVAH WTSETSEGIS AGSPTSGSTH
IFGEPLGAST TRISETSFST TPTDRTATSL SDGILPPQPT AAHSSATPVP VTHMFSLPVN
GSSVVAEETE VTMSEPSTLA RAFSTSVLSD VSNLSSTTMT TALVPPLDQT ASTTIVIVPT
HGDLIRTTSE ATVISVRKTS MAVPSLTETP FHSLRLSTPV TAKAETTLFS TSVDTVTPST
HTLVCSKPPP DNIPPASSTH VISTTSTPEA TQPISQVEET STYALSFPYT FSGGGVVASL
ATGTTETSVV DETTPSHISA NKLTTSVNSH ISSSATYRVH TPVSIQLVTS TSVLSSDKDQ
MTISLGKTPR TMEVTEMSPS KNSFISYSRG TPSLEMTDTG FPETTKISSH QTHSPSEIPL
GTPSDGNLAS SPTSGSTQIT PTLTSSNTVG VHIPEMSTSL GKTALPSQAL TITTFLCPEK
ESTSALPAYT PRTVEMIVNS TYVTHSVSYG QDTSFVDTTT SSSTRISNPM DINTTFSHLH
SLRTQPEVTS VASFISESTQ TFPESLSLST AGLYNDGFTV LSDRITTAFS VPNVPTMLPR
ESSMATSTPI YQMSSLPVNV TAFTSKKVSD TPPIVITKSS KTMHPGCLKS PCTATSGPMS
EMSSIPVNNS AFTPATVSSD TSTRVGLFST LLSSVTPRTT MTMQTSTLDV TPVIYAGATS
KNKMVSSAFT TEMIEAPSRI TPTTFLSPTE PTLPFVKTVP TTIMAGIVTP FVGTTAFSPL
SSKSTGAISS IPKTTFSPFL SATQQSSQAD EATTLGILSG ITNRSLSTVN SGTGVALTDT
YSRITVPENM LSPTHADSLH TSFNIQVSPS LTSFKSASGP TKNVKTTTNC FSSNTRKMTS
LLEKTSLTNY ATSLNTPVSY PPWTPSSATL PSLTSFVYSP HSTEAEISTP KTSPPPTSQM
VEFPVLGTRM TSSNTQPLLM TSWNIPTAEG SQFPISTTIN VPTSNEMETE TLHLVPGPLS
TFTASQTGLV SKDVMAMSSI PMSGILPNHG LSENPSLSTS LRAITSTLAD VKHTFEKMTT
SVTPGTTLPS ILSGATSGSV ISKSPILTWL LSSLPSGSPP ATVSNAPHVM TSSTVEVSKS
TFLTSDMISA HPFTNLTTLP SATMSTILTR TIPTPTLGGI TTGFPTSLPM SINVTDDIVY
ISTHPEASSR TTITANPRTV SHPSSFSRKT MSPSTTDHTL SVGAMPLPSS TITSSWNRIP
TASSPSTLII PKPTLDSLLN IMTTTSTVPG ASFPLISTGV TYPFTATVSS PISSFFETTW
LDSTPSFLST EASTSPTATK STVSFYNVEM SFSVFVEEPR IPITSVINEF TENSLNSIFQ
NSEFSLATLE TQIKSRDISE EEMVMDRAIL EQREGQEMAT ISYVPYSCVC QVIIKASSSL
ASSELMRKIK SKIHGNFTHG NFTQDQLTLL VNCEHVAVKK LEPGNCKADE TASKYKGTYK
WLLTNPTETA QTRCIKNEDG NATRFCSISI NTGKSQWEKP KFKQCKLLQE LPDKIVDLAN
ITISDENAED VAEHILNLIN ESPALGKEET KIIVSKISDI SQCDEISMNL THVMLQIINV
VLEKQNNSAS DLHEISNEIL RIIERTGHKM EFSGQIANLT VAGLALAVLR GDHTFDGMAF
SIHSYEEGTD PEIFLGNVPV GGILASIYLP KSLTERIPLS NLQTILFNFF GQTSLFKTKN
VTKALTTYVV SASISDDMFI QNLADPVVIT LQHIGGNQNY GQVHCAFWDF ENNNGLGGWN
SSGCKVKETN VNYTICQCDH LTHFGVLMDL SRSTVDSVNE QILALITYTG CGISSIFLGV
AVVTYIAFHK LRKDYPAKIL INLCTALLML NLVFLINSWL SSFQKVGVCI TAAVALHYFL
LVSFTWMGLE AVHMYLALVK VFNIYIPNYI LKFCLVGWGI PAIMVAITVS VKKDLYGTLS
PTTPFCWIKD DSIFYISVVA YFCLIFLMNL SMFCTVLVQL NSVKSQIQKT RRKMILHDLK
GTMSLTFLLG LTWGFAFFAW GPMRNFFLYL FAIFNTLQGF FIFVFHCVMK ESVREQWQIH
LCCGWLRLDN SSDGSSRCQI KVGYKQEGLK KIFEHKLLTP SLKSTATSST FKSLGSAQGT
PSEISFPNDD FDKDPYCSSP
