AGRF3_HUMAN
ID AGRF3_HUMAN Reviewed; 1079 AA.
AC Q8IZF5; B4DF15; E9PEV1; Q53TA5; Q6UXT7; Q6UXX3; Q86SL7; Q8IXD8; Q8TDT3;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Adhesion G-protein coupled receptor F3;
DE AltName: Full=G-protein coupled receptor 113;
DE AltName: Full=G-protein coupled receptor PGR23;
DE Flags: Precursor;
GN Name=ADGRF3; Synonyms=GPR113, PGR23; ORFNames=UNQ9196/PRO34000;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=12435584; DOI=10.1016/s0014-5793(02)03574-3;
RA Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B.;
RT "Novel human G protein-coupled receptors with long N-terminals containing
RT GPS domains and Ser/Thr-rich regions.";
RL FEBS Lett. 531:407-414(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT THR-404.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 563-1079.
RX PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT "Identification of G protein-coupled receptor genes from the human genome
RT sequence.";
RL FEBS Lett. 520:97-101(2002).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 797-942.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
RN [8]
RP NOMENCLATURE.
RX PubMed=25713288; DOI=10.1124/pr.114.009647;
RA Hamann J., Aust G., Arac D., Engel F.B., Formstone C., Fredriksson R.,
RA Hall R.A., Harty B.L., Kirchhoff C., Knapp B., Krishnan A., Liebscher I.,
RA Lin H.H., Martinelli D.C., Monk K.R., Peeters M.C., Piao X., Promel S.,
RA Schoneberg T., Schwartz T.W., Singer K., Stacey M., Ushkaryov Y.A.,
RA Vallon M., Wolfrum U., Wright M.W., Xu L., Langenhan T., Schioth H.B.;
RT "International union of basic and clinical pharmacology. XCIV. Adhesion G
RT protein-coupled receptors.";
RL Pharmacol. Rev. 67:338-367(2015).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8IZF5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IZF5-2; Sequence=VSP_012815, VSP_012816, VSP_012817;
CC Name=3;
CC IsoId=Q8IZF5-3; Sequence=VSP_046174, VSP_046175;
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB89332.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC45265.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY140955; AAN46669.1; -; mRNA.
DR EMBL; AB065959; BAC45265.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AY358172; AAQ88539.1; -; mRNA.
DR EMBL; AY358214; AAQ88581.1; -; Transcribed_RNA.
DR EMBL; AB083619; BAB89332.1; ALT_INIT; Genomic_DNA.
DR EMBL; AK293887; BAG57276.1; -; mRNA.
DR EMBL; AC010896; AAY14645.1; -; Genomic_DNA.
DR EMBL; AY255611; AAO85123.1; -; mRNA.
DR CCDS; CCDS33159.2; -. [Q8IZF5-2]
DR CCDS; CCDS46238.1; -. [Q8IZF5-3]
DR CCDS; CCDS46239.1; -. [Q8IZF5-1]
DR RefSeq; NP_001138640.1; NM_001145168.1. [Q8IZF5-1]
DR RefSeq; NP_001138641.1; NM_001145169.1. [Q8IZF5-3]
DR RefSeq; NP_001308900.1; NM_001321971.1.
DR RefSeq; NP_001308904.1; NM_001321975.1.
DR RefSeq; NP_722577.2; NM_153835.3. [Q8IZF5-2]
DR AlphaFoldDB; Q8IZF5; -.
DR SMR; Q8IZF5; -.
DR BioGRID; 127907; 20.
DR STRING; 9606.ENSP00000307831; -.
DR ChEMBL; CHEMBL4523891; -.
DR MEROPS; P02.028; -.
DR GlyGen; Q8IZF5; 6 sites.
DR iPTMnet; Q8IZF5; -.
DR PhosphoSitePlus; Q8IZF5; -.
DR BioMuta; ADGRF3; -.
DR DMDM; 59797951; -.
DR MaxQB; Q8IZF5; -.
DR PaxDb; Q8IZF5; -.
DR PeptideAtlas; Q8IZF5; -.
DR PRIDE; Q8IZF5; -.
DR Antibodypedia; 52007; 76 antibodies from 21 providers.
DR DNASU; 165082; -.
DR Ensembl; ENST00000311519.5; ENSP00000307831.1; ENSG00000173567.16. [Q8IZF5-1]
DR Ensembl; ENST00000333478.10; ENSP00000327396.6; ENSG00000173567.16. [Q8IZF5-2]
DR Ensembl; ENST00000421160.6; ENSP00000388537.2; ENSG00000173567.16. [Q8IZF5-3]
DR Ensembl; ENST00000447444.5; ENSP00000404775.1; ENSG00000173567.16. [Q8IZF5-2]
DR GeneID; 165082; -.
DR KEGG; hsa:165082; -.
DR UCSC; uc002rhd.2; human. [Q8IZF5-1]
DR CTD; 165082; -.
DR DisGeNET; 165082; -.
DR GeneCards; ADGRF3; -.
DR HGNC; HGNC:18989; ADGRF3.
DR HPA; ENSG00000173567; Not detected.
DR neXtProt; NX_Q8IZF5; -.
DR OpenTargets; ENSG00000173567; -.
DR PharmGKB; PA134918027; -.
DR VEuPathDB; HostDB:ENSG00000173567; -.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000161541; -.
DR HOGENOM; CLU_010357_0_0_1; -.
DR InParanoid; Q8IZF5; -.
DR OMA; YQWNASV; -.
DR OrthoDB; 311123at2759; -.
DR PhylomeDB; Q8IZF5; -.
DR TreeFam; TF316380; -.
DR PathwayCommons; Q8IZF5; -.
DR BioGRID-ORCS; 165082; 15 hits in 1068 CRISPR screens.
DR GeneWiki; GPR113; -.
DR GenomeRNAi; 165082; -.
DR Pharos; Q8IZF5; Tdark.
DR PRO; PR:Q8IZF5; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8IZF5; protein.
DR Bgee; ENSG00000173567; Expressed in islet of Langerhans and 93 other tissues.
DR ExpressionAtlas; Q8IZF5; baseline and differential.
DR Genevisible; Q8IZF5; HS.
DR GO; GO:0016021; C:integral component of membrane; TAS:GDB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:GDB.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; -; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF111418; SSF111418; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Signal; Transducer; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..1079
FT /note="Adhesion G-protein coupled receptor F3"
FT /id="PRO_0000012893"
FT TOPO_DOM 26..775
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 776..796
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 797..811
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 812..832
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 833..851
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 852..874
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 875..881
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 882..902
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 903..928
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 929..949
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 950..973
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 974..994
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 995..1002
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 1003..1023
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1024..1079
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT DOMAIN 712..764
FT /note="GPS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00098"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 264
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 301
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 382
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 441
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 648
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..97
FT /note="MVCSAAPLLLLATTLPLLGSPVAQASQPVSETGVRPREGLQRRQWGPLIGRD
FT KAWNERIDRPFPACPIPLSSSFGRWPKGQTMWAQTSTLTLTEEEL -> MTTRKLSAHS
FT AATPGYKAVTHKHHTGWARMAKTGLPEK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_012815"
FT VAR_SEQ 29..97
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_046174"
FT VAR_SEQ 168..307
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_012816"
FT VAR_SEQ 1048..1079
FT /note="VSCCLQILSCASKSMSEGIPWPSSEDMGTARS -> ATNEGCILEHSKGGSD
FT TARKTDASE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_012817"
FT VAR_SEQ 1048..1079
FT /note="VSCCLQILSCASKSMSEGIPWPSSEDMGTARS -> ATNEGCILEHSKGGSD
FT TAR (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_046175"
FT VARIANT 404
FT /note="A -> T (in dbSNP:rs2052937)"
FT /evidence="ECO:0000269|PubMed:12975309"
FT /id="VAR_024475"
FT CONFLICT 348
FT /note="A -> V (in Ref. 3; AAQ88539)"
FT /evidence="ECO:0000305"
FT CONFLICT 599
FT /note="H -> Y (in Ref. 3; AAQ88539)"
FT /evidence="ECO:0000305"
FT CONFLICT 765
FT /note="P -> S (in Ref. 4; BAG57276)"
FT /evidence="ECO:0000305"
FT CONFLICT 886
FT /note="M -> T (in Ref. 3; AAQ88581)"
FT /evidence="ECO:0000305"
FT CONFLICT Q8IZF5-2:868
FT /note="K -> N (in Ref. 3; AAQ88581)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1079 AA; 116341 MW; A18CA158F4DDBB9C CRC64;
MVCSAAPLLL LATTLPLLGS PVAQASQPVS ETGVRPREGL QRRQWGPLIG RDKAWNERID
RPFPACPIPL SSSFGRWPKG QTMWAQTSTL TLTEEELGQS QAGGESGSGQ LLDQENGAGE
SALVSVYVHL DFPDKTWPPE LSRTLTLPAA SASSSPRPLL TGLRLTTECN VNHKGNFYCA
CLSGYQWNTS ICLHYPPCQS LHNHQPCGCL VFSHPEPGYC QLLPPGSPVT CLPAVPGILN
LNSQLQMPGD TLSLTLHLSQ EATNLSWFLR HPGSPSPILL QPGTQVSVTS SHGQAALSVS
NMSHHWAGEY MSCFEAQGFK WNLYEVVRVP LKATDVARLP YQLSISCATS PGFQLSCCIP
STNLAYTAAW SPGEGSKASS FNESGSQCFV LAVQRCPMAD TTYACDLQSL GLAPLRVPIS
ITIIQDGDIT CPEDASVLTW NVTKAGHVAQ APCPESKRGI VRRLCGADGV WGPVHSSCTD
ARLLALFTRT KLLQAGQGSP AEEVPQILAQ LPGQAAEASS PSDLLTLLST MKYVAKVVAE
ARIQLDRRAL KNLLIATDKV LDMDTRSLWT LAQARKPWAG STLLLAVETL ACSLCPQDHP
FAFSLPNVLL QSQLFGPTFP ADYSISFPTR PPLQAQIPRH SLAPLVRNGT EISITSLVLR
KLDHLLPSNY GQGLGDSLYA TPGLVLVISI MAGDRAFSQG EVIMDFGNTD GSPHCVFWDH
SLFQGRGGWS KEGCQAQVAS ASPTAQCLCQ HLTAFSVLMS PHTVPEEPAL ALLTQVGLGA
SILALLVCLG VYWLVWRVVV RNKISYFRHA ALLNMVFCLL AADTCFLGAP FLSPGPRSPL
CLAAAFLCHF LYLATFFWML AQALVLAHQL LFVFHQLAKH RVLPLMVLLG YLCPLGLAGV
TLGLYLPQGQ YLREGECWLD GKGGALYTFV GPVLAIIGVN GLVLAMAMLK LLRPSLSEGP
PAEKRQALLG VIKALLILTP IFGLTWGLGL ATLLEEVSTV PHYIFTILNT LQGVFILLFG
CLMDRKIQEA LRKRFCRAQA PSSTISLVSC CLQILSCASK SMSEGIPWPS SEDMGTARS
