ID   ERH_PIG                 Reviewed;          32 AA.
AC   P80230; P37110;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Enhancer of rudimentary homolog;
DE   Contains:
DE     RecName: Full=Antibacterial peptide 3910;
DE              Short=AP 3910;
DE   Flags: Fragment;
GN   Name=ERH;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Intestine;
RX   PubMed=8375398; DOI=10.1111/j.1432-1033.1993.tb18182.x;
RA   Agerberth B., Boman A., Andersson M., Joernvall H., Mutt V., Boman H.G.;
RT   "Isolation of three antibacterial peptides from pig intestine: gastric
RT   inhibitory polypeptide (7-42), diazepam-binding inhibitor (32-86) and a
RT   novel factor, peptide 3910.";
RL   Eur. J. Biochem. 216:623-629(1993).
CC   -!- FUNCTION: May have a role in the cell cycle. {ECO:0000250}.
CC   -!- FUNCTION: AP 3910 has antibacterial activity against B.megaterium.
CC   -!- SUBUNIT: Homodimer. Component of the methylosome, a 20S complex
CC       containing at least CLNS1A/pICln, PRMT5/SKB1, WDR77/MEP50, PRMT1 and
CC       ERH. Interacts with CHTOP. {ECO:0000250|UniProtKB:P84089,
CC       ECO:0000250|UniProtKB:P84090}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P84090}.
CC   -!- SIMILARITY: Belongs to the E(R) family. {ECO:0000305}.
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DR   PIR; S36841; S36841.
DR   AlphaFoldDB; P80230; -.
DR   SMR; P80230; -.
DR   STRING; 9823.ENSSSCP00000002505; -.
DR   PaxDb; P80230; -.
DR   PeptideAtlas; P80230; -.
DR   PRIDE; P80230; -.
DR   eggNOG; KOG1766; Eukaryota.
DR   HOGENOM; CLU_125703_1_0_1; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   Genevisible; P80230; SS.
DR   GO; GO:0034709; C:methylosome; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISO:UniProtKB.
DR   GO; GO:0008327; F:methyl-CpG binding; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2260.10; -; 1.
DR   InterPro; IPR035912; EHR_sf.
DR   InterPro; IPR000781; ERH.
DR   PANTHER; PTHR12373; PTHR12373; 1.
DR   Pfam; PF01133; ER; 1.
DR   SUPFAM; SSF143875; SSF143875; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Cell cycle; Direct protein sequencing; Nucleus;
KW   Reference proteome.
FT   PEPTIDE         1..32
FT                   /note="Antibacterial peptide 3910"
FT                   /id="PRO_0000008414"
FT   NON_TER         1
SQ   SEQUENCE   32 AA;  3910 MW;  C1C418CACD680ED1 CRC64;
     RADTQTYQPY NKDWIKEKIY VLLRRQAQQA GK