ERF92_ARATH
ID ERF92_ARATH Reviewed; 218 AA.
AC Q8LDC8; Q9ZNR2;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Ethylene-responsive transcription factor 1B;
DE Short=AtERF1B;
DE AltName: Full=Ethylene-responsive element-binding factor 1B;
DE Short=EREBP-1B;
GN Name=ERF1B; Synonyms=ERF092, ERF1; OrderedLocusNames=At3g23240;
GN ORFNames=K14B15.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, AND INDUCTION.
RC STRAIN=cv. Columbia;
RX PubMed=9851977; DOI=10.1101/gad.12.23.3703;
RA Solano R., Stepanova A.N., Chao Q., Ecker J.R.;
RT "Nuclear events in ethylene signaling: a transcriptional cascade mediated
RT by ETHYLENE-INSENSITIVE3 and ETHYLENE-RESPONSE-FACTOR1.";
RL Genes Dev. 12:3703-3714(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, AND INDUCTION.
RX PubMed=12060224; DOI=10.1046/j.1365-313x.2002.01191.x;
RA Berrocal-Lobo M., Molina A., Solano R.;
RT "Constitutive expression of ETHYLENE-RESPONSE-FACTOR1 in Arabidopsis
RT confers resistance to several necrotrophic fungi.";
RL Plant J. 29:23-32(2002).
RN [7]
RP FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=11950980; DOI=10.1104/pp.010862;
RA Onate-Sanchez L., Singh K.B.;
RT "Identification of Arabidopsis ethylene-responsive element binding factors
RT with distinct induction kinetics after pathogen infection.";
RL Plant Physiol. 128:1313-1322(2002).
RN [8]
RP FUNCTION, AND INDUCTION.
RX PubMed=12509529; DOI=10.1105/tpc.007468;
RA Lorenzo O., Piqueras R., Sanchez-Serrano J.J., Solano R.;
RT "ETHYLENE RESPONSE FACTOR1 integrates signals from ethylene and jasmonate
RT pathways in plant defense.";
RL Plant Cell 15:165-178(2003).
RN [9]
RP INDUCTION.
RX PubMed=12805630; DOI=10.1104/pp.102.017814;
RA Brown R.L., Kazan K., McGrath K.C., Maclean D.J., Manners J.M.;
RT "A role for the GCC-box in jasmonate-mediated activation of the PDF1.2 gene
RT of Arabidopsis.";
RL Plant Physiol. 132:1020-1032(2003).
RN [10]
RP FUNCTION, AND INDUCTION.
RX PubMed=15242170; DOI=10.1094/mpmi.2004.17.7.763;
RA Berrocal-Lobo M., Molina A.;
RT "Ethylene response factor 1 mediates Arabidopsis resistance to the
RT soilborne fungus Fusarium oxysporum.";
RL Mol. Plant Microbe Interact. 17:763-770(2004).
RN [11]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16407444; DOI=10.1104/pp.105.073783;
RA Nakano T., Suzuki K., Fujimura T., Shinshi H.;
RT "Genome-wide analysis of the ERF gene family in Arabidopsis and rice.";
RL Plant Physiol. 140:411-432(2006).
RN [12]
RP INTERACTION WITH TAF12B.
RC STRAIN=cv. Wassilewskija;
RX PubMed=17526916; DOI=10.1093/jxb/erm080;
RA Robles L.M., Wampole J.S., Christians M.J., Larsen P.B.;
RT "Arabidopsis enhanced ethylene response 4 encodes an EIN3-interacting TFIID
RT transcription factor required for proper ethylene response, including ERF1
RT induction.";
RL J. Exp. Bot. 58:2627-2639(2007).
RN [13]
RP INTERACTION WITH MED25.
RX PubMed=21343311; DOI=10.1093/mp/ssr002;
RA Ou B., Yin K.Q., Liu S.N., Yang Y., Gu T., Wing Hui J.M., Zhang L.,
RA Miao J., Kondou Y., Matsui M., Gu H.Y., Qu L.J.;
RT "A high-throughput screening system for Arabidopsis transcription factors
RT and its application to Med25-dependent transcriptional regulation.";
RL Mol. Plant 4:546-555(2011).
CC -!- FUNCTION: Acts as a transcriptional activator. Binds to the GCC-box
CC pathogenesis-related promoter element. Involved in the regulation of
CC gene expression during the plant development, and/or mediated by stress
CC factors and by components of stress signal transduction pathways. Seems
CC to be a key integrator of ethylene and jasmonate signals in the
CC regulation of ethylene/jasmonate-dependent defenses. Can mediate
CC resistance to necrotizing fungi (Botrytis cinerea and Plectosphaerella
CC cucumerina) and to soil borne fungi (Fusarium oxysporum conglutinans
CC and Fusiarium oxysporum lycopersici), but probably not to necrotizing
CC bacteria (Pseudomonas syringae tomato). {ECO:0000269|PubMed:11950980,
CC ECO:0000269|PubMed:12060224, ECO:0000269|PubMed:12509529,
CC ECO:0000269|PubMed:15242170, ECO:0000269|PubMed:9851977}.
CC -!- SUBUNIT: Interacts with MED25 and TAF12B. {ECO:0000269|PubMed:17526916,
CC ECO:0000269|PubMed:21343311}.
CC -!- INTERACTION:
CC Q8LDC8; Q8L7G9: At4g17680; NbExp=3; IntAct=EBI-15197679, EBI-4424427;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed, mostly in flowers and
CC rosettes after ethylene treatment. {ECO:0000269|PubMed:11950980}.
CC -!- INDUCTION: Induced by Pseudomonas syringae tomato (both virulent and
CC avirulent avrRpt2 strains), independently of PAD4. Ethylene induction
CC is completely dependent on functional ETHYLENE-INSENSITIVE2 (EIN2),
CC ETHYLENE-INSENSITIVE3 (EIN3), which is itself a transcription factor
CC and CORONATIVE-INSENSITIVE1 (COI1) proteins. Induction by jasmonate,
CC B.cinerea or F.oxysporum as well as the synergistic induction by
CC ethylene and jasmonate requires EIN2 and COI1. Induction by methyl
CC jasmonate (MeJA) is independent of JAR1. Induction by salicylic acid
CC (SA) is dependent on NPR1 but not on PAD4. Seems not to be induced by
CC Alternaria brassicicola. {ECO:0000269|PubMed:11950980,
CC ECO:0000269|PubMed:12060224, ECO:0000269|PubMed:12509529,
CC ECO:0000269|PubMed:12805630, ECO:0000269|PubMed:15242170,
CC ECO:0000269|PubMed:9851977}.
CC -!- DOMAIN: The AP2/ERF domain binds specifically to the 5'-GCCGCC-3'
CC motif. The affinity of this binding is higher if the seventh amino-acid
CC of this domain is basic (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the AP2/ERF transcription factor family. ERF
CC subfamily. {ECO:0000305}.
CC -!- CAUTION: Two different genes At3g23240 and At4g17500 were assigned the
CC same gene name ERF1. {ECO:0000305}.
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DR EMBL; AF076277; AAD03544.1; -; mRNA.
DR EMBL; AF076278; AAD03545.1; -; Genomic_DNA.
DR EMBL; AB025608; BAA95737.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76738.1; -; Genomic_DNA.
DR EMBL; AF428390; AAL16158.1; -; mRNA.
DR EMBL; AY133629; AAM91459.1; -; mRNA.
DR EMBL; AY086078; AAM63284.1; -; mRNA.
DR RefSeq; NP_188965.1; NM_113225.3.
DR AlphaFoldDB; Q8LDC8; -.
DR SMR; Q8LDC8; -.
DR BioGRID; 7234; 12.
DR IntAct; Q8LDC8; 11.
DR STRING; 3702.AT3G23240.1; -.
DR PaxDb; Q8LDC8; -.
DR PRIDE; Q8LDC8; -.
DR EnsemblPlants; AT3G23240.1; AT3G23240.1; AT3G23240.
DR GeneID; 821902; -.
DR Gramene; AT3G23240.1; AT3G23240.1; AT3G23240.
DR KEGG; ath:AT3G23240; -.
DR Araport; AT3G23240; -.
DR TAIR; locus:2086223; AT3G23240.
DR eggNOG; ENOG502RBAX; Eukaryota.
DR HOGENOM; CLU_058713_1_1_1; -.
DR InParanoid; Q8LDC8; -.
DR OMA; MNYSIFH; -.
DR OrthoDB; 1363724at2759; -.
DR PhylomeDB; Q8LDC8; -.
DR PRO; PR:Q8LDC8; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q8LDC8; baseline and differential.
DR Genevisible; Q8LDC8; AT.
DR GO; GO:0005634; C:nucleus; TAS:TAIR.
DR GO; GO:0003677; F:DNA binding; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0006952; P:defense response; IMP:TAIR.
DR GO; GO:0009873; P:ethylene-activated signaling pathway; IGI:TAIR.
DR GO; GO:0009867; P:jasmonic acid mediated signaling pathway; TAS:TAIR.
DR CDD; cd00018; AP2; 1.
DR Gene3D; 3.30.730.10; -; 1.
DR InterPro; IPR001471; AP2/ERF_dom.
DR InterPro; IPR036955; AP2/ERF_dom_sf.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR044808; ERF_plant.
DR PANTHER; PTHR31190; PTHR31190; 1.
DR Pfam; PF00847; AP2; 1.
DR PRINTS; PR00367; ETHRSPELEMNT.
DR SMART; SM00380; AP2; 1.
DR SUPFAM; SSF54171; SSF54171; 1.
DR PROSITE; PS51032; AP2_ERF; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Ethylene signaling pathway; Nucleus; Plant defense;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..218
FT /note="Ethylene-responsive transcription factor 1B"
FT /id="PRO_0000112543"
FT DNA_BIND 81..139
FT /note="AP2/ERF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 165..181
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 11..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 4
FT /note="F -> L (in Ref. 5; AAM63284)"
FT /evidence="ECO:0000305"
FT CONFLICT 24
FT /note="D -> E (in Ref. 5; AAM63284)"
FT /evidence="ECO:0000305"
FT CONFLICT 64..65
FT /note="DS -> EL (in Ref. 5; AAM63284)"
FT /evidence="ECO:0000305"
FT CONFLICT 152
FT /note="Y -> C (in Ref. 5; AAM63284)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 218 AA; 24695 MW; 91739B3DDB15F3C2 CRC64;
MDPFLIQSPF SGFSPEYSIG SSPDSFSSSS SNNYSLPFNE NDSEEMFLYG LIEQSTQQTY
IDSDSQDLPI KSVSSRKSEK SYRGVRRRPW GKFAAEIRDS TRNGIRVWLG TFESAEEAAL
AYDQAAFSMR GSSAILNFSA ERVQESLSEI KYTYEDGCSP VVALKRKHSM RRRMTNKKTK
DSDFDHRSVK LDNVVVFEDL GEQYLEELLG SSENSGTW
