ERDL8_ARATH
ID ERDL8_ARATH Reviewed; 470 AA.
AC Q0WQ63; Q9MAA4;
DT 14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Sugar transporter ERD6-like 8;
GN OrderedLocusNames=At3g05150; ORFNames=T12H1.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 8-470.
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY.
RX PubMed=16923188; DOI=10.1186/1471-2148-6-64;
RA Johnson D.A., Hill J.P., Thomas M.A.;
RT "The monosaccharide transporter gene family in land plants is ancient and
RT shows differential subfamily expression and expansion across lineages.";
RL BMC Evol. Biol. 6:64-64(2006).
CC -!- FUNCTION: Sugar transporter. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF27021.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC009177; AAF27021.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE74191.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM64576.1; -; Genomic_DNA.
DR EMBL; AK228841; BAF00736.1; -; mRNA.
DR RefSeq; NP_001326593.1; NM_001337565.1.
DR RefSeq; NP_187166.2; NM_111387.5.
DR AlphaFoldDB; Q0WQ63; -.
DR SMR; Q0WQ63; -.
DR BioGRID; 5012; 23.
DR IntAct; Q0WQ63; 22.
DR STRING; 3702.AT3G05150.1; -.
DR PaxDb; Q0WQ63; -.
DR PRIDE; Q0WQ63; -.
DR ProteomicsDB; 220672; -.
DR EnsemblPlants; AT3G05150.1; AT3G05150.1; AT3G05150.
DR EnsemblPlants; AT3G05150.3; AT3G05150.3; AT3G05150.
DR GeneID; 819677; -.
DR Gramene; AT3G05150.1; AT3G05150.1; AT3G05150.
DR Gramene; AT3G05150.3; AT3G05150.3; AT3G05150.
DR KEGG; ath:AT3G05150; -.
DR Araport; AT3G05150; -.
DR TAIR; locus:2096219; AT3G05150.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_001265_30_5_1; -.
DR InParanoid; Q0WQ63; -.
DR PhylomeDB; Q0WQ63; -.
DR PRO; PR:Q0WQ63; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q0WQ63; baseline and differential.
DR Genevisible; Q0WQ63; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd17358; MFS_GLUT6_8_Class3_like; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR044775; MFS_ERD6/Tret1-like.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..470
FT /note="Sugar transporter ERD6-like 8"
FT /id="PRO_0000259858"
FT TRANSMEM 33..53
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..355
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..429
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 434..454
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 470 AA; 51024 MW; 250305540EA6CF59 CRC64;
METRKDDMEK RNDKSEPLLL PENGSDVSEE ASWMVYLSTI IAVCGSYEFG TCVGYSAPTQ
FGIMEELNLS YSQFSVFGSI LNMGAVLGAI TSGKISDFIG RKGAMRLSSV ISAIGWLIIY
LAKGDVPLDF GRFLTGYGCG TLSFVVPVFI AEISPRKLRG ALATLNQLFI VIGLASMFLI
GAVVNWRTLA LTGVAPCVVL FFGTWFIPES PRWLEMVGRH SDFEIALQKL RGPQANITRE
AGEIQEYLAS LAHLPKATLM DLIDKKNIRF VIVGVGLMFF QQFVGINGVI FYAQQIFVSA
GASPTLGSIL YSIEQVVLTA LGATLLIDRL GRRPLLMASA VGMLIGCLLI GNSFLLKAHG
LALDIIPALA VSGVLVYIGS FSIGMGAIPW VIMSEIFPIN LKGTAGGLVT VVNWLSSWLV
SFTFNFLMIW SPHGTFYVYG GVCVLAIIFI AKLVPETKGR TLEEIQAMMM
