ID   ENTC3_STAAN             Reviewed;         266 AA.
AC   P0A0L4; P23313;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Enterotoxin type C-3;
DE   AltName: Full=SEC3;
DE   Flags: Precursor;
GN   Name=entC3; OrderedLocusNames=SA1817;
OS   Staphylococcus aureus (strain N315).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N315;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Staphylococcal enterotoxin that activates the host immune
CC       system by binding as unprocessed molecules to major histocompatibility
CC       (MHC) complex class II and T-cell receptor (TCR) molecules. In turn,
CC       this ternary complex activates a large number of T-lymphocytes
CC       initiating a systemic release of pro-inflammatory cytokines (By
CC       similarity). Causes also the intoxication staphylococcal food poisoning
CC       syndrome (By similarity). {ECO:0000250|UniProtKB:P0A0L5,
CC       ECO:0000250|UniProtKB:P34071}.
CC   -!- SUBUNIT: Interacts with MHC class II molecules composed of alpha/HLA-
CC       DRA and beta/HLA-DRB1 chains. Interacts with host T-cell receptor/TCR
CC       beta variable chain TRBV8-2. {ECO:0000250|UniProtKB:P0A0L5}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the staphylococcal/streptococcal toxin family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000018; BAB43097.1; -; Genomic_DNA.
DR   RefSeq; WP_000278088.1; NC_002745.2.
DR   AlphaFoldDB; P0A0L4; -.
DR   SMR; P0A0L4; -.
DR   Allergome; 2141; Sta a SEC.
DR   EnsemblBacteria; BAB43097; BAB43097; BAB43097.
DR   KEGG; sau:SA1817; -.
DR   HOGENOM; CLU_093855_0_1_9; -.
DR   OMA; KFTGLME; -.
DR   PRO; PR:P0A0L4; -.
DR   Proteomes; UP000000751; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR008992; Enterotoxin.
DR   InterPro; IPR006126; Staph/Strept_toxin_CS.
DR   InterPro; IPR006173; Staph_tox_OB.
DR   InterPro; IPR016091; SuperAg_toxin_C.
DR   InterPro; IPR013307; Superantigen_bac.
DR   InterPro; IPR006123; Toxin_b-grasp_Staph/Strep.
DR   InterPro; IPR006177; Toxin_bac.
DR   Pfam; PF02876; Stap_Strp_tox_C; 1.
DR   Pfam; PF01123; Stap_Strp_toxin; 1.
DR   PRINTS; PR00279; BACTRLTOXIN.
DR   PRINTS; PR01898; SAGSUPRFAMLY.
DR   SUPFAM; SSF50203; SSF50203; 1.
DR   SUPFAM; SSF54334; SSF54334; 1.
DR   PROSITE; PS00277; STAPH_STREP_TOXIN_1; 1.
DR   PROSITE; PS00278; STAPH_STREP_TOXIN_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Enterotoxin; Metal-binding; Secreted; Signal; Superantigen;
KW   Toxin; Virulence; Zinc.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000250"
FT   CHAIN           28..266
FT                   /note="Enterotoxin type C-3"
FT                   /id="PRO_0000035610"
FT   DISULFID        120..137
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   266 AA;  30671 MW;  5ED8A32D11FFCA59 CRC64;
     MYKRLFISRV ILIFALILVI STPNVLAESQ PDPMPDDLHK SSEFTGTMGN MKYLYDDHYV
     SATKVKSVDK FLAHDLIYNI SDKKLKNYDK VKTELLNEDL AKKYKDEVVD VYGSNYYVNC
     YFSSKDNVGK VTGGKTCMYG GITKHEGNHF DNGNLQNVLV RVYENKRNTI SFEVQTDKKS
     VTAQELDIKA RNFLINKKNL YEFNSSPYET GYIKFIENNG NTFWYDMMPA PGDKFDQSKY
     LMMYNDNKTV DSKSVKIEVH LTTKNG