EIF3B_COCIM
ID EIF3B_COCIM Reviewed; 739 AA.
AC Q1DI97; J3K132;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Eukaryotic translation initiation factor 3 90 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3 p90 {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Translation initiation factor eIF3 p90 subunit homolog;
GN Name=PRT1 {ECO:0000255|HAMAP-Rule:MF_03001}; ORFNames=CIMG_09966;
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS;
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=RS;
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000255|HAMAP-
CC Rule:MF_03001}.
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DR EMBL; GG704915; EAS27361.3; -; Genomic_DNA.
DR RefSeq; XP_001238944.1; XM_001238943.2.
DR AlphaFoldDB; Q1DI97; -.
DR SMR; Q1DI97; -.
DR STRING; 246410.Q1DI97; -.
DR EnsemblFungi; EAS27361; EAS27361; CIMG_09966.
DR GeneID; 4558133; -.
DR KEGG; cim:CIMG_09966; -.
DR VEuPathDB; FungiDB:CIMG_09966; -.
DR InParanoid; Q1DI97; -.
DR OMA; NVADCKI; -.
DR OrthoDB; 1194797at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR CDD; cd12278; RRM_eIF3B; 1.
DR Gene3D; 2.130.10.10; -; 2.
DR Gene3D; 3.30.70.330; -; 1.
DR HAMAP; MF_03001; eIF3b; 1.
DR InterPro; IPR011400; EIF3B.
DR InterPro; IPR034363; eIF3B_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR14068; PTHR14068; 1.
DR Pfam; PF08662; eIF2A; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF036424; eIF3b; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW Repeat; RNA-binding; WD repeat.
FT CHAIN 1..739
FT /note="Eukaryotic translation initiation factor 3 subunit
FT B"
FT /id="PRO_0000363816"
FT DOMAIN 39..125
FT /note="RRM"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REPEAT 191..229
FT /note="WD 1"
FT REPEAT 231..288
FT /note="WD 2"
FT REPEAT 457..498
FT /note="WD 3"
FT REPEAT 516..559
FT /note="WD 4"
FT REPEAT 574..612
FT /note="WD 5"
SQ SEQUENCE 739 AA; 84140 MW; FD31CC105F4D387E CRC64;
MAPSFDTLSE QDLHEEEVEI DFSDLKAQYE VRLEEGLDAF VVIDGLPVVP EESKPKLIKF
LLKKLNTVGR TREDAIFMPL NEKGMSEGFA FVEYDTPEQA IAATKHLHGT PLDKKHTLAV
NKLTDIDRYG REGRVDEEYT PPKIEPFQEK EHLRSWLGDP NARDQFAMYR GDKVGVFWNM
KNNPPENVVD RDHWTQLFVQ WSPLGTYLAS VHPQGVQLWG GPQFGKQKQF PHPFVSLMEF
SPGEKYLTTW SSRPIQLDGP PGALSYEEEG KNIIIWDITT GKPLRSFVSH ELAAPAGPDG
DAAQAKKKVQ WPAFKWSADE KFVARMLPGQ SISIYELPRM NLLDRTSVKI EGVMDFEWSP
ATVQREGVKQ SEQLLSFWTP EIGSNPAKVG LMSIPSKEVV RTRNLFNVSD VKLHWQSQGA
YVCVKVDRHS KSKKSLATNL EIFRVREKGV PVEVVDSLKD TVINFAWEPK GNRFVLITTG
EVPTGTAVPP KTAVSFFAPE KTKSGAAGNF KLVRTIEKKT SNGIYWSPKG RFVVVATVHS
QQHFDIDFWD LDFEGEKPEN EKDLSANLQL MKTNEHFGVT DIDWDPTGRY VVSSASAWTH
SLENGYHIHT FSGTTLTEHA VEKFKQLVWR PRPPTLLSKE EQKKVRRNLR EYSREFDEED
KYAVDIANTA IVEMRKRLLN EWTAWLKKEK EMVEEEREVL GLPKYEEEPA AKPTPGAEDD
TIVEEIVEEI IEESEEIVA
