ID   EI24_ARATH              Reviewed;         320 AA.
AC   Q5BPL5; Q5XV84;
DT   01-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Protein EI24 homolog;
GN   OrderedLocusNames=At4g06676; ORFNames=T2N12.19;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11853315; DOI=10.1093/dnares/8.6.285;
RA   Kumekawa N., Hosouchi T., Tsuruoka H., Kotani H.;
RT   "The size and sequence organization of the centromeric region of
RT   Arabidopsis thaliana chromosome 4.";
RL   DNA Res. 8:285-290(2001).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA   Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences.;
CC       Name=1;
CC         IsoId=Q5BPL5-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the EI24 (TC 9.B.7) family. {ECO:0000305}.
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DR   EMBL; AB073164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002687; AEE82556.1; -; Genomic_DNA.
DR   EMBL; AY735638; AAU44508.1; -; mRNA.
DR   EMBL; AY924813; AAX23888.1; -; mRNA.
DR   RefSeq; NP_849325.4; NM_178994.5. [Q5BPL5-1]
DR   AlphaFoldDB; Q5BPL5; -.
DR   STRING; 3702.AT4G06676.1; -.
DR   TCDB; 2.A.121.3.3; the sulfate transporter (cysz) family.
DR   PaxDb; Q5BPL5; -.
DR   PRIDE; Q5BPL5; -.
DR   ProteomicsDB; 222260; -. [Q5BPL5-1]
DR   EnsemblPlants; AT4G06676.1; AT4G06676.1; AT4G06676. [Q5BPL5-1]
DR   GeneID; 826112; -.
DR   Gramene; AT4G06676.1; AT4G06676.1; AT4G06676. [Q5BPL5-1]
DR   KEGG; ath:AT4G06676; -.
DR   Araport; AT4G06676; -.
DR   TAIR; locus:1005716216; AT4G06676.
DR   eggNOG; KOG3966; Eukaryota.
DR   InParanoid; Q5BPL5; -.
DR   OrthoDB; 889537at2759; -.
DR   PhylomeDB; Q5BPL5; -.
DR   PRO; PR:Q5BPL5; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; Q5BPL5; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016236; P:macroautophagy; IBA:GO_Central.
DR   InterPro; IPR009890; EI24.
DR   PANTHER; PTHR21389; PTHR21389; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..320
FT                   /note="Protein EI24 homolog"
FT                   /id="PRO_0000430419"
FT   TRANSMEM        41..61
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..312
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        217
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        42
FT                   /note="C -> R (in Ref. 3; AAU44508)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        111
FT                   /note="S -> G (in Ref. 3; AAU44508)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   320 AA;  36208 MW;  E8849C218E45F408 CRC64;
     MRSKSKQVLL LWLEGFREAC SLHRVVILCL RSRKLLLRTG QCFLLNGLIF LGSLGVFKWF
     IDPSLQWILP DQCSPLTSQE FCSYGGFYAF LRGGLLQLFY VFWFYPLYML SFILSNIWYN
     DIAKHGFEAI EISDLNSAEA LRQGEALASL NMANAERPSG LGGVMIGIGE QVYSILLLTF
     FFLEVCVVGV IPYIGKILNF LLLSWMYAYY CYEYKWNFSG ISLKKRLDFF QSNWAFFAGF
     GSPCVLAIFF LSPLVSGALM AILFPLFVLT ATGSGPEKLI GAPRRTWKCA GLGKLPIFYI
     ADTLSMLALS IFRLESPHEN