ID   EFC4A_RAT               Reviewed;         393 AA.
AC   B0BNK9;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=EF-hand calcium-binding domain-containing protein 4A;
DE   AltName: Full=Calcium release-activated channel regulator 2B;
GN   Name=Cracr2b; Synonyms=Efcab4a;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays a role in store-operated Ca(2+) entry (SOCE).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EFCAB4 family. {ECO:0000305}.
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DR   EMBL; CH473953; EDM12067.1; -; Genomic_DNA.
DR   EMBL; CH473953; EDM12068.1; -; Genomic_DNA.
DR   EMBL; CH473953; EDM12069.1; -; Genomic_DNA.
DR   EMBL; BC158864; AAI58865.1; -; mRNA.
DR   RefSeq; NP_001121013.1; NM_001127541.1.
DR   RefSeq; XP_006230621.1; XM_006230559.3.
DR   RefSeq; XP_006230623.1; XM_006230561.3.
DR   RefSeq; XP_006230657.1; XM_006230595.3.
DR   RefSeq; XP_006230658.1; XM_006230596.3.
DR   RefSeq; XP_006230659.1; XM_006230597.3.
DR   RefSeq; XP_017459705.1; XM_017604216.1.
DR   RefSeq; XP_017459708.1; XM_017604219.1.
DR   RefSeq; XP_017459713.1; XM_017604224.1.
DR   AlphaFoldDB; B0BNK9; -.
DR   SMR; B0BNK9; -.
DR   STRING; 10116.ENSRNOP00000025964; -.
DR   PhosphoSitePlus; B0BNK9; -.
DR   PaxDb; B0BNK9; -.
DR   PeptideAtlas; B0BNK9; -.
DR   PRIDE; B0BNK9; -.
DR   Ensembl; ENSRNOT00000025964; ENSRNOP00000025964; ENSRNOG00000019199.
DR   GeneID; 309112; -.
DR   KEGG; rno:309112; -.
DR   UCSC; RGD:1560911; rat.
DR   CTD; 283229; -.
DR   RGD; 1560911; Cracr2b.
DR   eggNOG; ENOG502QRXK; Eukaryota.
DR   GeneTree; ENSGT00440000033504; -.
DR   HOGENOM; CLU_047014_1_0_1; -.
DR   InParanoid; B0BNK9; -.
DR   OMA; GRREQTQ; -.
DR   OrthoDB; 1113066at2759; -.
DR   PhylomeDB; B0BNK9; -.
DR   TreeFam; TF329556; -.
DR   PRO; PR:B0BNK9; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Proteomes; UP000234681; Chromosome 1.
DR   Bgee; ENSRNOG00000019199; Expressed in stomach and 16 other tissues.
DR   Genevisible; B0BNK9; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:2001256; P:regulation of store-operated calcium entry; ISO:RGD.
DR   GO; GO:0002115; P:store-operated calcium entry; ISS:UniProtKB.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   SMART; SM00054; EFh; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..393
FT                   /note="EF-hand calcium-binding domain-containing protein
FT                   4A"
FT                   /id="PRO_0000395806"
FT   DOMAIN          28..63
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          65..97
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          214..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          173..352
FT                   /evidence="ECO:0000255"
FT   MOD_RES         3
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N4Y2"
SQ   SEQUENCE   393 AA;  44553 MW;  62C2637729FDB780 CRC64;
     MASPGPPGAG QGQEEEERAG VSAGHQAEVL QQAQELFVLC DKDAKGFITR QDLQGLQSDL
     PLTPEQLEAV FESLDQAHTG FLTAREFCLG LGKFVGVESV PGRAPLRTPE ETFESGTGGS
     LEEEDDVETF YTSLEKLGVA RVLGEQWAVR TLWVGLQRER PELLGSLEEI LMRASACLEA
     AARERDGLEQ ALRRRESEHE REVRGLYEEL EQQLREQRQR RQSQNPPREE ERGHLELELQ
     TREQELERAA LRQRELEQQL QARAAEQLEV QAQHIQLQRA YEALRAQLDQ AQEQLIRLEG
     EAQGRQEQTQ RDVVAVSRNM QKEKLSLLRQ LELLRELNLR LRDERDACET KLLGSSHRKA
     LAIAHKPGPI YCCCCCGWAR PPRRGSGHLP SAR