EF1B_SCHPO
ID EF1B_SCHPO Reviewed; 214 AA.
AC O74173; Q10249;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Elongation factor 1-beta;
DE Short=EF-1-beta;
GN Name=tef5; ORFNames=SPCC1450.04;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kawamukai M.;
RT "S.pombe elongation factor 1 beta.";
RL Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 2-214.
RC STRAIN=972 / ATCC 24843;
RX PubMed=9099890; DOI=10.1016/s0378-1119(96)00764-0;
RA Mita K., Morimyo M., Ito K., Sugaya K., Ebihara K., Hongo E., Higashi T.,
RA Hirayama Y., Nakamura Y.;
RT "Comprehensive cloning of Schizosaccharomyces pombe genes encoding
RT translation elongation factors.";
RL Gene 187:259-266(1997).
CC -!- FUNCTION: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound
CC to EF-1-alpha to GTP.
CC -!- SUBUNIT: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
CC -!- SIMILARITY: Belongs to the EF-1-beta/EF-1-delta family. {ECO:0000305}.
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DR EMBL; AB016046; BAA31571.1; -; mRNA.
DR EMBL; CU329672; CAB40171.1; -; Genomic_DNA.
DR EMBL; D82574; BAA11572.1; -; mRNA.
DR PIR; T40986; T40986.
DR PIR; T43285; T43285.
DR RefSeq; NP_588303.1; NM_001023293.2.
DR AlphaFoldDB; O74173; -.
DR SMR; O74173; -.
DR BioGRID; 275843; 7.
DR STRING; 4896.SPCC1450.04.1; -.
DR iPTMnet; O74173; -.
DR MaxQB; O74173; -.
DR PaxDb; O74173; -.
DR PRIDE; O74173; -.
DR EnsemblFungi; SPCC1450.04.1; SPCC1450.04.1:pep; SPCC1450.04.
DR GeneID; 2539275; -.
DR KEGG; spo:SPCC1450.04; -.
DR PomBase; SPCC1450.04; tef5.
DR VEuPathDB; FungiDB:SPCC1450.04; -.
DR eggNOG; KOG1668; Eukaryota.
DR HOGENOM; CLU_050172_0_2_1; -.
DR InParanoid; O74173; -.
DR OMA; FEVKPWD; -.
DR PhylomeDB; O74173; -.
DR Reactome; R-SPO-156842; Eukaryotic Translation Elongation.
DR PRO; PR:O74173; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005853; C:eukaryotic translation elongation factor 1 complex; ISO:PomBase.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISO:PomBase.
DR GO; GO:0003746; F:translation elongation factor activity; ISO:PomBase.
DR GO; GO:0002182; P:cytoplasmic translational elongation; ISO:PomBase.
DR GO; GO:0006414; P:translational elongation; IBA:GO_Central.
DR CDD; cd00292; EF1B; 1.
DR Gene3D; 3.30.70.60; -; 1.
DR InterPro; IPR036219; eEF-1beta-like_sf.
DR InterPro; IPR018940; EF-1_beta_acid_region_euk.
DR InterPro; IPR014038; EF1B_bsu/dsu_GNE.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR014717; Transl_elong_EF1B/ribosomal_S6.
DR InterPro; IPR001326; Transl_elong_EF1B_B/D_CS.
DR Pfam; PF10587; EF-1_beta_acid; 1.
DR Pfam; PF00736; EF1_GNE; 1.
DR SMART; SM01182; EF-1_beta_acid; 1.
DR SMART; SM00888; EF1_GNE; 1.
DR SUPFAM; SSF47616; SSF47616; 1.
DR SUPFAM; SSF54984; SSF54984; 1.
DR PROSITE; PS00824; EF1BD_1; 1.
DR PROSITE; PS00825; EF1BD_2; 1.
PE 2: Evidence at transcript level;
KW Elongation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..214
FT /note="Elongation factor 1-beta"
FT /id="PRO_0000155041"
FT CONFLICT 66
FT /note="A -> T (in Ref. 3; BAA11572)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 214 AA; 23484 MW; 9D1E61BA0FE1EA6F CRC64;
MGFSDLTSDA GLKQLNDFLL DKSFIEGYEP SQADAVVFKA VGVAPDTAKY PNGARWYKQI
ATYDLATLPG TAKEVSAYGP EGAAAAEEDE IDLFGSDEEE DPEAERIKAE RVAEYNKKKA
AKPKAVHKSL VTLDVKPWDD ETPMDELEKA VRSIQMDGLV WGLSKLVPVG FGVNKFQINL
VVEDDKVSLE ALQEELEGFE DYVQSTDIAA MSKL
