ID   E411_ADE05              Reviewed;         116 AA.
AC   P04489;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   29-SEP-2021, entry version 80.
DE   RecName: Full=Probable early E4 11 kDa protein;
OS   Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus.
OX   NCBI_TaxID=28285;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7166756; DOI=10.1016/0022-2836(82)90389-8;
RA   Sarnow P., Hearing P., Anderson C.W., Reich N., Levine A.J.;
RT   "Identification and characterization of an immunologically conserved
RT   adenovirus early region 11,000 Mr protein and its association with the
RT   nuclear matrix.";
RL   J. Mol. Biol. 162:565-583(1982).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1727603; DOI=10.1016/0042-6822(92)90082-z;
RA   Chroboczek J., Bieber F., Jacrot B.;
RT   "The sequence of the genome of adenovirus type 5 and its comparison with
RT   the genome of adenovirus type 2.";
RL   Virology 186:280-285(1992).
CC   -!- INTERACTION:
CC       P04489; P04489: -; NbExp=5; IntAct=EBI-6398911, EBI-6398911;
CC       P04489; P29590-3: PML; Xeno; NbExp=4; IntAct=EBI-6398911, EBI-8099068;
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DR   EMBL; M73260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; X02998; CAA26757.1; -; Genomic_DNA.
DR   PIR; B03807; Q4ADE5.
DR   RefSeq; AP_000230.1; AC_000008.1.
DR   PDB; 4DJB; X-ray; 2.05 A; A/B=1-116.
DR   PDBsum; 4DJB; -.
DR   SMR; P04489; -.
DR   DIP; DIP-571N; -.
DR   IntAct; P04489; 3.
DR   MINT; P04489; -.
DR   PRO; PR:P04489; -.
DR   Proteomes; UP000004992; Genome.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   Gene3D; 3.30.70.2870; -; 1.
DR   InterPro; IPR009699; Mastadenovirus_E4/Orf3.
DR   InterPro; IPR038368; Mastadenovirus_E4/Orf3_sf.
DR   Pfam; PF06931; Adeno_E4_ORF3; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Early protein.
FT   CHAIN           1..116
FT                   /note="Probable early E4 11 kDa protein"
FT                   /id="PRO_0000221771"
FT   STRAND          2..10
FT                   /evidence="ECO:0007829|PDB:4DJB"
FT   HELIX           11..19
FT                   /evidence="ECO:0007829|PDB:4DJB"
FT   HELIX           24..37
FT                   /evidence="ECO:0007829|PDB:4DJB"
FT   HELIX           38..42
FT                   /evidence="ECO:0007829|PDB:4DJB"
FT   STRAND          47..53
FT                   /evidence="ECO:0007829|PDB:4DJB"
FT   STRAND          55..66
FT                   /evidence="ECO:0007829|PDB:4DJB"
FT   HELIX           70..96
FT                   /evidence="ECO:0007829|PDB:4DJB"
FT   STRAND          108..111
FT                   /evidence="ECO:0007829|PDB:4DJB"
SQ   SEQUENCE   116 AA;  13298 MW;  AE4EF38B8F81EE0A CRC64;
     MIRCLRLKVE GALEQIFTMA GLNIRDLLRD ILRRWRDENY LGMVEGAGMF IEEIHPEGFS
     LYVHLDVRAV CLLEAIVQHL TNAIICSLAV EFDHATGGER VHLIDLHFEV LDNLLE