ID   DYT2B_BOVIN             Reviewed;         152 AA.
AC   Q32P71;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Dynein light chain Tctex-type protein 2B {ECO:0000305};
DE   AltName: Full=Tctex1 domain-containing protein 2;
GN   Name=DYNLT2B; Synonyms=TCTEX1D2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as one of several non-catalytic accessory components of
CC       the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein
CC       complex that drives the movement of cargos along microtubules within
CC       cilia and flagella in concert with the intraflagellar transport (IFT)
CC       system. Required for proper retrograde ciliary transport.
CC       {ECO:0000250|UniProtKB:Q8WW35}.
CC   -!- SUBUNIT: Light chain of the cytoplasmic dynein complex 2, a
CC       multisubunit complex composed at least of eleven different proteins.
CC       The cytoplasmic dynein 2 complex consists of two catalytic heavy chains
CC       (HCs) and a number of non-catalytic subunits presented by intermediate
CC       chains (ICs), light intermediate chains (LICs) and light chains (LCs).
CC       Among them, a heavy chain (DYNC2H1), two intermediate chains (DYNC2I2
CC       and DYNC2I1), a light intermediate chain (DYNC2LI1), and a light chain
CC       (DYNLT2B) are unique to the dynein-2 complex, but a subset of the light
CC       chains are also shared by dynein-1 and dynein-2 complexes. The dimer
CC       DYNLT2B-DYNLT1/DYNLT3 interacts with DYNC2I1; this interaction is
CC       crucial for retrograde trafficking of ciliary proteins.
CC       {ECO:0000250|UniProtKB:Q8WW35}.
CC   -!- SUBCELLULAR LOCATION: Dynein axonemal particle
CC       {ECO:0000250|UniProtKB:Q8WW35}.
CC   -!- SIMILARITY: Belongs to the dynein light chain Tctex-type family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI08236.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC108235; AAI08236.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001160027.1; NM_001166555.1.
DR   AlphaFoldDB; Q32P71; -.
DR   SMR; Q32P71; -.
DR   STRING; 9913.ENSBTAP00000043713; -.
DR   PaxDb; Q32P71; -.
DR   GeneID; 504554; -.
DR   KEGG; bta:504554; -.
DR   CTD; 255758; -.
DR   eggNOG; KOG4108; Eukaryota.
DR   HOGENOM; CLU_097204_8_0_1; -.
DR   InParanoid; Q32P71; -.
DR   OrthoDB; 1434909at2759; -.
DR   TreeFam; TF313904; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005929; C:cilium; IEA:GOC.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005868; C:cytoplasmic dynein complex; ISS:UniProtKB.
DR   GO; GO:0120293; C:dynein axonemal particle; IEA:UniProtKB-SubCell.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IBA:GO_Central.
DR   GO; GO:0035721; P:intraciliary retrograde transport; ISS:UniProtKB.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   GO; GO:1905799; P:regulation of intraciliary retrograde transport; ISS:UniProtKB.
DR   Gene3D; 3.30.1140.40; -; 1.
DR   InterPro; IPR005334; Tctex-1-like.
DR   InterPro; IPR038586; Tctex-1-like_sf.
DR   PANTHER; PTHR21255; PTHR21255; 1.
DR   Pfam; PF03645; Tctex-1; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..152
FT                   /note="Dynein light chain Tctex-type protein 2B"
FT                   /id="PRO_0000316868"
SQ   SEQUENCE   152 AA;  17238 MW;  E299190D7D8F1191 CRC64;
     MSVAASFPKH TSFTMRASFA AADGLPETEN NAGEPENTYI LRPVFQQRFR PSVVKDCIHA
     VLKEELANAE YSPEEMPQLT KHLSENIKDK LKEMGFDRYK MVVQVVIGEQ RGEGVFMAAR
     CFWDADTDNC THDVFMNDSL FCVVAAFGCF YY