3HID2_ARATH
ID 3HID2_ARATH Reviewed; 299 AA.
AC Q9C991;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Probable 3-hydroxyisobutyrate dehydrogenase-like 2, mitochondrial;
DE Short=HIBADH-like;
DE EC=1.1.1.31;
GN OrderedLocusNames=At1g71170; ORFNames=F23N20.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-
CC oxopropanoate + H(+) + NADH; Xref=Rhea:RHEA:17681, ChEBI:CHEBI:11805,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57700,
CC ChEBI:CHEBI:57945; EC=1.1.1.31;
CC -!- PATHWAY: Amino-acid degradation; L-valine degradation.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate
CC dehydrogenase subfamily. {ECO:0000305}.
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DR EMBL; AC016972; AAG51697.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35168.1; -; Genomic_DNA.
DR EMBL; AK229143; BAF01017.1; -; mRNA.
DR PIR; D96736; D96736.
DR RefSeq; NP_565013.2; NM_105786.3.
DR AlphaFoldDB; Q9C991; -.
DR SMR; Q9C991; -.
DR STRING; 3702.AT1G71170.1; -.
DR PaxDb; Q9C991; -.
DR PRIDE; Q9C991; -.
DR ProteomicsDB; 244590; -.
DR EnsemblPlants; AT1G71170.1; AT1G71170.1; AT1G71170.
DR GeneID; 843457; -.
DR Gramene; AT1G71170.1; AT1G71170.1; AT1G71170.
DR KEGG; ath:AT1G71170; -.
DR Araport; AT1G71170; -.
DR TAIR; locus:2026341; AT1G71170.
DR eggNOG; KOG0409; Eukaryota.
DR HOGENOM; CLU_035117_1_0_1; -.
DR InParanoid; Q9C991; -.
DR OMA; HPGNQPV; -.
DR OrthoDB; 812358at2759; -.
DR PhylomeDB; Q9C991; -.
DR BioCyc; ARA:AT1G71170-MON; -.
DR UniPathway; UPA00362; -.
DR PRO; PR:Q9C991; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C991; baseline and differential.
DR Genevisible; Q9C991; AT.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006574; P:valine catabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.1040.10; -; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR029154; NADP-bd.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; SSF48179; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 2: Evidence at transcript level;
KW Branched-chain amino acid catabolism; Mitochondrion; NAD; Oxidoreductase;
KW Reference proteome.
FT CHAIN 1..299
FT /note="Probable 3-hydroxyisobutyrate dehydrogenase-like 2,
FT mitochondrial"
FT /id="PRO_0000421118"
FT ACT_SITE 182
FT /evidence="ECO:0000250"
FT BINDING 14..43
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT BINDING 108
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT BINDING 250
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
SQ SEQUENCE 299 AA; 31438 MW; 2E49DBD282A92359 CRC64;
METQYPKLIE PSKTRIGWIG IGIMGSAMVS HILAAGYSVT VYARDLRKTK DLQTKGGRTA
NSPKELGEMS DVVFTIVGNS NDVRSLLLGD DGVLSGLKPG GVTVDMTSSK PGLAREIYAE
ARRRDCWAVD APVSGGDAGA REGKLTIFAG GDSEIVEWLA PVMKTMGIVR FMGGAGSGQS
CKIGNQICVG SNMIGLAEGI VFAEKAGLDP VKWLEAVKDG AAGSAVMRLF GEMMAVRDYK
ATGFAEYMVK DLGMAAEAAM AMPGTALNKQ LFTVMVANGD GKLGFQGVVD VIRRLNGLS
