ID   DS7CA_DANRE             Reviewed;         324 AA.
AC   A8E5C5; Q502I7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Dehydrogenase/reductase SDR family member 7C-A;
DE            EC=1.1.-.-;
DE   Flags: Precursor;
GN   Name=dhrs7ca; ORFNames=zgc:112176;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=WIK; TISSUE=Larva;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative oxidoreductase. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; BC095682; AAH95682.1; -; mRNA.
DR   EMBL; BC153545; AAI53546.1; -; mRNA.
DR   RefSeq; NP_001018493.1; NM_001020657.1.
DR   AlphaFoldDB; A8E5C5; -.
DR   SMR; A8E5C5; -.
DR   STRING; 7955.ENSDARP00000097447; -.
DR   PaxDb; A8E5C5; -.
DR   PeptideAtlas; A8E5C5; -.
DR   Ensembl; ENSDART00000106669; ENSDARP00000097447; ENSDARG00000071877.
DR   GeneID; 553684; -.
DR   KEGG; dre:553684; -.
DR   CTD; 553684; -.
DR   ZFIN; ZDB-GENE-050522-226; dhrs7cb.
DR   eggNOG; KOG1205; Eukaryota.
DR   GeneTree; ENSGT00940000157100; -.
DR   HOGENOM; CLU_010194_2_1_1; -.
DR   InParanoid; A8E5C5; -.
DR   OrthoDB; 1313182at2759; -.
DR   PhylomeDB; A8E5C5; -.
DR   TreeFam; TF313474; -.
DR   PRO; PR:A8E5C5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 12.
DR   Bgee; ENSDARG00000071877; Expressed in muscle tissue and 14 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   NAD; NADP; Oxidoreductase; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..324
FT                   /note="Dehydrogenase/reductase SDR family member 7C-A"
FT                   /id="PRO_0000333757"
FT   ACT_SITE        191
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         41..65
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         178
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        266
FT                   /note="S -> G (in Ref. 1; AAH95682)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        272
FT                   /note="Q -> R (in Ref. 1; AAH95682)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   324 AA;  35182 MW;  910B95E08CDE6279 CRC64;
     MAVPSVMVLP LLIVVFAGVY YVYNEVMRFM SKSVVRNKVV VITDAVSGMG SECARLFHAG
     GARLVLCGPS WDKLESLYDS LCSGSDPSQT FTPKLVLLDF SDMENISDVV SEICECYGCV
     DVLICNSSMK VKAPVQNLSL EMDKTIMDVN YFGPITLAKG VLPLMITRRT GQFVLVNSIQ
     GKLALPFRTC YAASKHAVQA FFDCLRAEVE EFGISVSTIS HTFINAGAEN ATPTEATPIT
     ATPTKATPTN PIWAYVCSKL NTHGVSPQIL AQEIVRSVNR QSREVFLAHP VPTVALYIRA
     LMPGCFFSVV SAGVRDGAMA EQLK