ID   DRU_AGADC               Reviewed;          66 AA.
AC   O93455;
DT   04-MAY-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Dermaseptin PD-3-7 {ECO:0000303|PubMed:9774745};
DE   Flags: Precursor;
OS   Agalychnis dacnicolor (Giant mexican leaf frog) (Pachymedusa dacnicolor).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Agalychnis.
OX   NCBI_TaxID=75988;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skin;
RX   PubMed=9774745; DOI=10.1016/s0167-4838(98)00202-7;
RA   Wechselberger C.;
RT   "Cloning of cDNAs encoding new peptides of the dermaseptin-family.";
RL   Biochim. Biophys. Acta 1388:279-283(1998).
CC   -!- FUNCTION: Possesses a potent antimicrobial activity against Gram-
CC       positive and Gram-negative bacteria. Probably acts by disturbing
CC       membrane functions with its amphipathic structure (By similarity).
CC       {ECO:0000250}.
CC   -!- INTERACTION:
CC       O93455; O93455: -; NbExp=5; IntAct=EBI-7249529, EBI-7249529;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:9774745}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000305|PubMed:9774745}.
CC   -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC       URL="https://wangapd3.com/database/query_output.php?ID=1386";
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DR   EMBL; AJ005193; CAA06430.1; -; mRNA.
DR   AlphaFoldDB; O93455; -.
DR   MINT; O93455; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR004275; Frog_antimicrobial_propeptide.
DR   Pfam; PF03032; FSAP_sig_propep; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Cleavage on pair of basic residues; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..40
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000007087"
FT   PEPTIDE         43..66
FT                   /note="Dermaseptin PD-3-7"
FT                   /evidence="ECO:0000305|PubMed:9774745"
FT                   /id="PRO_0000007088"
SQ   SEQUENCE   66 AA;  7399 MW;  1783028D8750C051 CRC64;
     MSFMKKSLLL VLFLGVVSLS NCEEEKGENE NEDHEEHHEE KRLLGDLLGQ TSKLVNDLTD
     TVGSIV