DPY19_DROME
ID DPY19_DROME Reviewed; 872 AA.
AC Q9VWR8; Q7KUV6; Q9VWR9;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=C-mannosyltransferase dpy-19 homolog;
DE EC=2.4.1.-;
GN ORFNames=CG6659;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Probable C-mannosyltransferase that mediates C-mannosylation
CC of tryptophan residues on target proteins. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9VWR8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9VWR8-2; Sequence=VSP_029633;
CC -!- SIMILARITY: Belongs to the dpy-19 family. {ECO:0000305}.
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DR EMBL; AE014298; AAF48869.1; -; Genomic_DNA.
DR EMBL; AE014298; AAF48870.1; -; Genomic_DNA.
DR EMBL; AY122173; AAM52685.1; -; mRNA.
DR RefSeq; NP_573317.1; NM_133089.2. [Q9VWR8-1]
DR RefSeq; NP_728189.1; NM_167627.1. [Q9VWR8-2]
DR AlphaFoldDB; Q9VWR8; -.
DR BioGRID; 59166; 1.
DR IntAct; Q9VWR8; 1.
DR STRING; 7227.FBpp0074383; -.
DR PaxDb; Q9VWR8; -.
DR PRIDE; Q9VWR8; -.
DR DNASU; 32854; -.
DR EnsemblMetazoa; FBtr0074612; FBpp0074383; FBgn0030946. [Q9VWR8-1]
DR EnsemblMetazoa; FBtr0074613; FBpp0074384; FBgn0030946. [Q9VWR8-2]
DR GeneID; 32854; -.
DR KEGG; dme:Dmel_CG6659; -.
DR UCSC; CG6659-RA; d. melanogaster. [Q9VWR8-1]
DR FlyBase; FBgn0030946; CG6659.
DR VEuPathDB; VectorBase:FBgn0030946; -.
DR eggNOG; KOG4587; Eukaryota.
DR GeneTree; ENSGT00530000063023; -.
DR HOGENOM; CLU_334709_0_0_1; -.
DR InParanoid; Q9VWR8; -.
DR OMA; HDPLQGD; -.
DR PhylomeDB; Q9VWR8; -.
DR BioGRID-ORCS; 32854; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 32854; -.
DR PRO; PR:Q9VWR8; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0030946; Expressed in adult Malpighian tubule (Drosophila) and 29 other tissues.
DR Genevisible; Q9VWR8; DM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005637; C:nuclear inner membrane; IBA:GO_Central.
DR GO; GO:0000030; F:mannosyltransferase activity; IBA:GO_Central.
DR GO; GO:0018406; P:protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan; IBA:GO_Central.
DR InterPro; IPR030038; Dpy-19.
DR InterPro; IPR018732; Dpy-19/Dpy-19-like.
DR PANTHER; PTHR31488; PTHR31488; 1.
DR PANTHER; PTHR31488:SF1; PTHR31488:SF1; 1.
DR Pfam; PF10034; Dpy19; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Glycosyltransferase; Membrane;
KW Reference proteome; Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..872
FT /note="C-mannosyltransferase dpy-19 homolog"
FT /id="PRO_0000311884"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 627..647
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 678..698
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 514..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 508..535
FT /evidence="ECO:0000255"
FT COMPBIAS 517..563
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..594
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..115
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_029633"
SQ SEQUENCE 872 AA; 101097 MW; D00F126032922218 CRC64;
MREPNLYVIL SHALIGCGFF FLYVQHVRVI FETRTNIQQL NQLEREALLR REDALYYAFY
KQLAEGPDFW HGYEQLKNVT DIEYPHSVNV LQRFYVLPEL VTAYFFHVVR SGFNPMVQPM
QFYLEFVWLM GGVTLLVLYL YGTLLSENIF GGIYGVISYL MFHSFVAKIY ERPLARENFA
FPFIFLQMFY LCICIGRIIH RQRHTSRMFM IFAMSLFTAC ALLSWQFSTF IFTTQILIMM
TSWNASALPT ALVNAFVLDY SLSHLLGHAL AFVMSHGNSQ LLLTWQLSIS LFLFLITMVR
QLRHVRSRRL GHAQDLLNGD LFSLKFLMLT LLLASSVQTT LIELFNRAGV VSVTEGDQQH
FFDICAHWAL QVNVGFVAHL SACNPQYARV AWSELWQLVK TMIVKPYCMY GVVMLAMFFR
RWRKSGAPVS ALTEEQRERA RKYVLEDFIE EHFVSMSDMS SKETEKQLYK CFRLLKSCDY
DYERYKRAQA SLRKEQPPAR DDFMQDIKRL RAQINRNSVK QRKERAQETK EAATDGASTP
TEEEDKDPEA ESESKKKNQE PGSGETETES AADPTETPPS RSADNEEEEE EHSATAAGCG
SNSSGHRQRK RSSSRRSSVV PTANAQILNM HYVYSFLQML VFTLIGLAVR KLFFLSFTQG
CVIAPTVCSK LWYHRQRNIF WSVSLAVFLL SMFDPGMVNI REEYFPTRYS KSGDDLDSML
EWIKLNTERD AVFAGPVDII GTVHLTTKRP IVNHAHLEMR QIAERTEHVY SVYSRQQSSD
IYNQCAQLKI QYLIISLDEC TNEVRDDCDL LAIWDDKQPA YQKYPQFCHE LLHKNVPSFL
KVFANDHYGI IKMFSQSVQI NLKHNKMPEM SI
