ID   ADEC_KOSOT              Reviewed;         577 AA.
AC   C5CI63;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Adenine deaminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade {ECO:0000255|HAMAP-Rule:MF_01518}; OrderedLocusNames=Kole_2088;
OS   Kosmotoga olearia (strain ATCC BAA-1733 / DSM 21960 / TBF 19.5.1).
OC   Bacteria; Thermotogae; Kosmotogales; Kosmotogaceae; Kosmotoga.
OX   NCBI_TaxID=521045;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1733 / DSM 21960 / TBF 19.5.1;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.,
RA   Noll K.;
RT   "Complete sequence of Thermotogales bacterium TBF 19.5.1.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; CP001634; ACR80765.1; -; Genomic_DNA.
DR   RefSeq; WP_015869406.1; NC_012785.1.
DR   AlphaFoldDB; C5CI63; -.
DR   SMR; C5CI63; -.
DR   STRING; 521045.Kole_2088; -.
DR   EnsemblBacteria; ACR80765; ACR80765; Kole_2088.
DR   KEGG; kol:Kole_2088; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_0; -.
DR   OMA; TDHECFT; -.
DR   OrthoDB; 751534at2; -.
DR   Proteomes; UP000002382; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..577
FT                   /note="Adenine deaminase"
FT                   /id="PRO_1000215362"
SQ   SEQUENCE   577 AA;  63526 MW;  6C220F73FC7A689B CRC64;
     MNIIDIIPVA RGKQPADLLL KNARIVNVFS GEIERANIAI FRKRIAGIGD YSEGKQVIDL
     HGAYVVPGLI DAHLHIESSM VSPVEFAKTV LPRGTTTVIA DPHEIANVLG LDGVEYLIKS
     TEGVPLNLYI MLPSSVPATN LENNGARISV MDMIGFVEKH PRVLGLGEVM NYPDIINGDH
     DSIAKIELLR HKYKKIDGHI PGISGKDLNA YICAFIRSDH ECTNVEEAKE KLARGMQILV
     REGSVARNLD ELLPLINEKN YPFISFCTDD KHPNDILNEG HIDYMIRYAI KKGIDPITAV
     RAATINTARH YNLRSMGAIA PGYKADFVIV DNLEEFRISM VFKDSKLIAE NGKLVIDINR
     EQFPLEEVNT FKCPHIEEKD LEVLNKGENI RVIRVYGDDV LTKELRMEPK TKDGRIVSDV
     NRDILKVASI CRYCEEKSMA IGFINGTGLK QGAVATSVGH DAHNMSVIGT NDADMVVAAN
     RVIDMGGGLV IANSGKVLAE LPLPIAGLMS NLSSKEVAER LGHLKTVLKE LGCEVPDLFM
     TLSFVQLSVI PELRITNQGL VDVINNNFVS LFIGKEG