DOP1_PLAF7
ID DOP1_PLAF7 Reviewed; 3933 AA.
AC O97239;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 23-FEB-2022, entry version 101.
DE RecName: Full=Protein dopey homolog PFC0245c;
GN ORFNames=PFC0245c;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1] {ECO:0000312|EMBL:CAB39005.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=10448855; DOI=10.1038/22964;
RA Bowman S., Lawson D., Basham D., Brown D., Chillingworth T., Churcher C.M.,
RA Craig A., Davies R.M., Devlin K., Feltwell T., Gentles S., Gwilliam R.,
RA Hamlin N., Harris D., Holroyd S., Hornsby T., Horrocks P., Jagels K.,
RA Jassal B., Kyes S., McLean J., Moule S., Mungall K.L., Murphy L.,
RA Oliver K., Quail M.A., Rajandream M.A., Rutter S., Skelton J., Squares R.,
RA Squares S., Sulston J.E., Whitehead S., Woodward J.R., Newbold C.,
RA Barrell B.G.;
RT "The complete nucleotide sequence of chromosome 3 of Plasmodium
RT falciparum.";
RL Nature 400:532-538(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [3] {ECO:0000312|EMBL:CAB39005.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [4] {ECO:0000305}
RP SYNTHESIS OF 2215-2262, DEVELOPMENTAL STAGE, AND POSSIBLE CANDIDATE MALARIA
RP EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
CC -!- FUNCTION: May be involved in protein traffic between late Golgi and
CC early endosomes. {ECO:0000250|UniProtKB:Q9Y7B3}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DEVELOPMENTAL STAGE: Expressed during the asexual cell-cycle on the
CC cell surface of the host erythrocytes. {ECO:0000269|PubMed:17653272}.
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
CC -!- SIMILARITY: Belongs to the dopey family. {ECO:0000255}.
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DR EMBL; AL844502; CAB39005.1; -; Genomic_DNA.
DR RefSeq; XP_001351131.1; XM_001351095.1.
DR BioGRID; 1209624; 7.
DR IntAct; O97239; 7.
DR STRING; 5833.PFC0245c; -.
DR PRIDE; O97239; -.
DR EnsemblProtists; CAB39005; CAB39005; PF3D7_0305500.
DR GeneID; 814373; -.
DR KEGG; pfa:PF3D7_0305500; -.
DR VEuPathDB; PlasmoDB:PF3D7_0305500; -.
DR HOGENOM; CLU_225426_0_0_1; -.
DR InParanoid; O97239; -.
DR OMA; HIYLNIC; -.
DR PhylomeDB; O97239; -.
DR Proteomes; UP000001450; Chromosome 3.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR GO; GO:0005777; C:peroxisome; NAS:UniProtKB.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0006895; P:Golgi to endosome transport; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR040314; DOP1.
DR InterPro; IPR007249; Dopey_N.
DR PANTHER; PTHR14042; PTHR14042; 2.
DR Pfam; PF04118; Dopey_N; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Membrane; Merozoite; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..3933
FT /note="Protein dopey homolog PFC0245c"
FT /id="PRO_0000356827"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 782..802
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 842..862
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1186..1206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1462..1482
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1997..2017
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 2860..2880
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 2905..2925
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 3017..3037
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 3200..3220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 3276..3296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 468..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1216..1284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1361..1405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2691..2739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3620..3646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 620..651
FT /evidence="ECO:0000255"
FT COILED 1349..1403
FT /evidence="ECO:0000255"
FT COILED 3897..3925
FT /evidence="ECO:0000255"
FT COMPBIAS 468..492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..640
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..656
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1216..1255
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1264..1283
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2700..2739
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3933 AA; 467882 MW; 5144A4604EE36933 CRC64;
MIKKSEESKR LLRKKLNNDI TNILLLFEKV QEWADLSNIL QKLYLTIEKY ELFVNVSSKF
LLFRRLSQCL NPLLPSGVHS KALIIYSSIF KKVEMDFFIN NIHILCSGIF EFMLHCTINL
KTIYFKNIKS ILRLKENVYI FAYALLLSLF NVVDSDNNIL LYIYSINNYI GENIFFNNIW
LLLLRHPEIR TNILNFLEAS FSPQIYLLSK ERIKMLLPYK DHLVLSSIIY CLNDKNILNQ
RITLSLLINN FPLSHVPNKK NKKKIIDKSK SNDYHMDKPP YSPFNASTSS VILNNSNMDS
MNDNRINENN INNNDNKRHN IQINNDYLFG DMMNKQNDTT IMQSNKMLNR HNIIGEQHLD
DDLLSSIHDD NSEKKNNNNF MLLNENNKIS TSKEHLDNMH NRGIKSHEDI MGSNQNKMNL
SNDEKDHWGG NLNSKVGNYD DKNICGKKHL GLKSEYGQVS YDESLERRLN NNNNNNNNNN
NNNNNNGDNL KYQGSVDYDE HDISMSTEND KYGKMGNENM NDVFISKGKM MRKGYEDDGH
HHININDDDN LNYDDNEDDE YGNYHNNNYN DRNYFNEYDE DDQYENNNNN NHSNNNNMLH
LGSVDRNRRK QLKKKINNIG QTNNYDDDEE EEDEEEEDNN NNTSYNNNNN NSSSSSSIFF
SDTSKKLIAR NVIFLLKKSD IGLNRRIFKY LYLYESNDEK NFKDKEINFE NYKIYCETII
DILENKSDDN YNSIAEVIYI LFKNKDYINI NRYIMEQVFL YLLNFCYKNR EDTSIKSFLK
NMLNLNLISY ENILNIFLYT FYYLRRNDDL FVHYTNIYIK KYINLLNIMT FFVEFIKHMN
KYLYIQFLFH FNLATLKLMN FLNLKIINII KKYSHVKDLN EKYFIDSNDV VSGRHSTLYY
FYFFVTHYNN YYLNKCLSII VKDILPQNPS NRKMGNYQSH YYANNKHMLY MNTHEIHSAR
MEEYSNKIQK VGFKNEIVDR KNKYDNNEYS ESEIKMRAVD NSMNYIKRKV KKKNMESKDS
SNSMSNMEIN TNSTMANRLN HMQHIQHDGI SSMEHMNNKI NDNNNNNNVN YFFDGNNSNN
NNNNNILENN NKLYFDKGYN GNYSKIENDQ SFHNILMKYK FKLKQNLIDA IIKNHELYFF
TNNCEYIIFL FYNYHLLIEK EKLNKSCFYF LKNILNNCTC ENKNKFYFWC FLFLHIIRIN
FNKSLLKNYK IKEAGDDTDD DDDDDDDDDD EEEDDDDEDD DDEDDEEEDD EEDLGVDGLK
NMSSKKGKKK KKKSVHKNKL MNKKYGRGGS SKYYYYLTSD KEIMLHGGMM GGVNYSDMEH
DEDNLDVDDE DEQMFSYNKN KIRNKHFGEL NKMKYMNEDI TNNNNNINNN SNNNNNNKNN
INNNNNNNNN NNNNNNNLNN LNNFNNNVSI NNGNNKYRNY FRSTEEELLF NKRFVEFLLP
YSNNIAKYIF QYIKILKKNK KFIKLFFDIN YLYFFCDNMF CLKILKKSLK CKDNHELTIN
VKVILEYIIN SKTNEYHIIH SNFYNLTHDV FKLYNRRNNL INYYLIKYIM RNKENLSYIF
DNIIISMFDL ITEIENLYEK IEMMKKDLSY SMMNNNDHVY DPNGMIEAAD QRKSHYVSLK
DNMNNMNNMN NVNNMNNVNN MNNVNNVNNV NNVNYHNNTI NNNNNNNNFS NHTSYVNEKT
QENNYHNLMN TYEKYLKKLK CKFDYISYFF LNMENFMLWL YKHKISKKIY HSRNKMTLTN
YEKNMAIIIC YICTEGNINS FFFRNYLDVF FILFLKIIYL NENISELNNS ANNIIQKEKN
NLKHNSLLEF KRDTLSMLNN IFNINHNKKF EYMKILNLYY RQIIHHLLFL YYYFTVKKYY
VLQLQLVHFI RYILPLYEKN IDKKFLTNES TEKDKVFKRM KYNNYEEFIS ASKYHFEIIN
RNNYNMKNDV FIFSILRKSM TIIFNLNEQV LYKEVLKTII DLIENIIDEK EVKNYYLTVF
FLDLLYIIKM EDQKKKKNIF FIMKFCQFLI EIFKLIYRDE MKNELKCDKK FQDDNITIDI
IENALSNNKM STASFCTIFS IKTDDKFVNV QHKNISNLFS VIFNLYAFLK KKIKLYYKHN
KHLINNDDKN NVVNNNSYIY YDNNSNVYNN NNTNIYNNNN NNENNAFNNN MPNNSNIMNN
MNNMNDIYHI SQHTNNNIRY NDVSSCGARG HNINSNENVN QNDLNNNSNY NYNRGMNNMN
GDINNINGDI NNMNGDINNM NGDINNMNGD INNMNGDINN MNGGNFKNPN SYNNNNNMNS
YYSHNSSDYH KDNDNMRNNV NSSNSNFHNN NQDVQIMNRK NDSDGNVGNF DNNSTYSYMN
NVNNDISMRL TNINNNNNIN INNNNNNNNN LFAYNKNNPN ALVNNMNNQD KPDQHNNSHQ
YMYKENDMNQ FGNSNYNNMD NTNNKFYNNY NYGKNVEGHT IYDNNNNNNN NSNNGAVNIN
SVQGENNVMS RNNILFNHNV NNNEYYFSQK NEDNMASMNN NHHNNYHNNN NNHHNNNINN
HHNNNINNHH NMNRNNNIYS EDSKTNECYS MREKMGDVNV AYNSNFYDDK NNYTHMKNDL
IKNEQKNNYG FCNNHENTFI YNCKNRMNRN NYAFNMGSKK NKKIMLLKVC LSNIISINKL
LYFITRPEFL FIDNLYSIFK DYIKNRNEYN KERLSKSDYY YEQREKLYKE HRRKMNRQNI
RTDSSNNNNN NNINSNNNNN NNNNNNNNNN NNNNNNIYNN NNYYYSSSIN KVSFDDDEKI
EVESFLDHNG VVGSNKKIKR EKIREYFKKE KNLLKKLNFM TKFSKNTIKK SMIVMNNSDE
CIEKKKLSFS LTLLTEFDDV ILIKIIDDLL NYYEKYKSKI NLNEFMYFLF NIYLNICTLT
KRIINHFIDF IFSFIKKITQ TSQNIMSSLW FLYILFIIEN NHIYVFNDKL QKKIIVEQIS
ILIQISLYSY YSKNVKNNYN IQTPLPNFVQ PFNIYYIIQN YFINNNYFHI KKNNKNIRYF
YIKNLKLIEK NFNINDYSEI AAINALSFLL MCFYHTVNYN GTNKSYICES SVNIFYEHFS
KYISLIYNNS LQNIFYRYVF LLIMNLLIDY NANSKYYIKK ITFDLYSYIT NVDIRCIKAL
STLFKKLNET NIDELLLVPT SSIFSLKFNI INSRINYINK LSLIILAGNR NFYLCHLPKI
AENISEYIKF CNDLKLYREI LILICIIIIK NDENEIYIII PTFISLILQI YHVERIKYKM
AVENINNIDK DDDNYIYDFN SYNNKDVLSL LKTLLIIINI LIKRNVSFIN FYSWIFFKDI
SIKKNRLEQQ NREPGNLMIY PGHKTLVYNN KKKKQKNVVR YVSSSSDKDE SSVYNISVDE
ENSLKTQGRF FDDTYYKRKD NSGYTNKMKN FNSLTYEDKS SLMTGNQTSS TKDVGGMVNN
AIRQNIEQNN MIHPNQINNN NNNNNNNNNV YNFNDFTNSM NQPNVINNNK KKKAFTTDDY
FVKYDENQKV TKQTKLNHHN EDNLNDTITV YLNSNQEDYL YESKNNFTSI RSEHISSMVD
IKKGSILNSN NILTNDNNTN NNIHSNIHNG SSSNNNNNNN SVCTGIKLDE SKFVPFLDII
ERIYSPNNIL NKKYVSSEEL KNEKSTRTYN SSLQEGSDYD EEEDEEYDVD ADVDVDVDVD
DDDDDDVDIV DVDVDDVVVD YNYYDNENNS VKIIDVDERK RSVHFYPQHL DGNTLKKNLY
YNDNYLREYI LSTKNELSGY SSFENNLSSS SVNSIKSNFS NTFSKDNINK NIITDDTSDD
NDMMNSNNNM NSMMVPYNMH MTDDEFQENI NNNNNNNNNN NDNMYLSSDD GYPSQSNHKW
IHFNSLLNYD IHELSKKKKK KKKKISIHSC KNLPLVLVYL SKKIKLNFYK YSMKKPKEET
IILLKELNSV ENDINDLFLE VDLNEVYYDF LIR
