ID   DNAK_ANAMM              Reviewed;         645 AA.
AC   Q5PAB8;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=AM842;
OS   Anaplasma marginale (strain St. Maries).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Anaplasma.
OX   NCBI_TaxID=234826;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=St. Maries;
RX   PubMed=15618402; DOI=10.1073/pnas.0406656102;
RA   Brayton K.A., Kappmeyer L.S., Herndon D.R., Dark M.J., Tibbals D.L.,
RA   Palmer G.H., McGuire T.C., Knowles D.P. Jr.;
RT   "Complete genome sequencing of Anaplasma marginale reveals that the surface
RT   is skewed to two superfamilies of outer membrane proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:844-849(2005).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; CP000030; AAV86762.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5PAB8; -.
DR   SMR; Q5PAB8; -.
DR   PRIDE; Q5PAB8; -.
DR   KEGG; ama:AM842; -.
DR   HOGENOM; CLU_005965_2_1_5; -.
DR   OMA; ISIKRHM; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Stress response.
FT   CHAIN           1..645
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_0000225929"
FT   REGION          603..645
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        606..625
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        626..645
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         200
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   645 AA;  69935 MW;  7C5834D0B53F5B56 CRC64;
     MGVIMAAERI IGIDLGTTNS CVAVMEAGTA KVIENSEGSR TTPSVVAFTE NERLVGELAK
     RQANINAQNT IYASKRIIGR RYDDMRDVKC PYEVFPAKNG DAWIRARGEG YSPVQIGAFV
     LEKIKETAER YFGAPVKKAV ITVPAYFNDA QRQATKDAGT IAGLDVVRII NEPTAAALAY
     GLDKGDKQRT IVVYDLGGGT FDVSVLEIAE GVFEVKATNG DTKLGGEDFD NAVMEHMMES
     FKQETGIDLH NDPMAVQRIK EAAEKAKIEL SSRLETDITL PFISSDSTGA KHLSLKLTRA
     KFEGLVSELI ERTIEPCKKA LDDAGIKDTS KIDEVVLVGG MTRMPKVIQR VKDFFGGKEP
     CKGVNPDEVV AIGAAIQGGI LTGDVRDVLL LDVAPLSLGI ETLGGVFTPL IERNTTIPTK
     KSQVFSTAED GQTAVTIKVY QGERKMAVDN KLLGQFSLEG IPSAPRGIPQ IEVTFDIDAN
     GIVHVSAKDK ASGKEQTIKI QSSGGLSEEE IKKMVQDAQD RAEEDEKRKK RVELKNSAEA
     LIHSTEKSLN DYGDKISSAD KSGIEAAIKE LRECLSNDDS SSDVIQQKYD ALMQLSMKLG
     EAAYSAQKDS GTSTDSTASD TSGNPEERVV DSEYQEIKKD DEDKK