DMRTC_MOUSE
ID DMRTC_MOUSE Reviewed; 182 AA.
AC Q9D9R7; B1AX31; B1AX32; Q2PMY0; Q9D5U3;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Doublesex- and mab-3-related transcription factor C1;
DE AltName: Full=Doublesex- and mab-3-related transcription factor 8.1;
GN Name=Dmrtc1; Synonyms=Dmrt8.1, Dmrtc1a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), AND TISSUE SPECIFICITY.
RX PubMed=16488114; DOI=10.1016/j.ygeno.2006.01.003;
RA Veith A.-M., Klattig J., Dettai A., Schmidt C., Englert C., Volff J.-N.;
RT "Male-biased expression of X-chromosomal DM domain-less Dmrt8 genes in the
RT mouse.";
RL Genomics 88:185-195(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 (ISOFORM 3), AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=isoform c;
CC IsoId=Q9D9R7-1; Sequence=Displayed;
CC Name=2; Synonyms=isoform b;
CC IsoId=Q9D9R7-2; Sequence=VSP_019523, VSP_019524;
CC Name=3; Synonyms=isoform a;
CC IsoId=Q9D9R7-3; Sequence=VSP_019522, VSP_019523, VSP_019524;
CC -!- TISSUE SPECIFICITY: Expressed in Sertoli cells in male testis.
CC {ECO:0000269|PubMed:16488114}.
CC -!- DEVELOPMENTAL STAGE: Detected in many tissues at 13.5 dpc.
CC -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
CC -!- CAUTION: Although related to other DMRT proteins, it does not contain a
CC canonical DM DNA-binding domain. {ECO:0000305}.
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DR EMBL; DQ316772; ABC48232.1; -; mRNA.
DR EMBL; DQ316773; ABC48233.1; -; mRNA.
DR EMBL; DQ316774; ABC48234.1; -; mRNA.
DR EMBL; AK006548; BAB24647.1; -; mRNA.
DR EMBL; AK014934; BAB29626.1; -; mRNA.
DR EMBL; AL773565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS30327.1; -. [Q9D9R7-3]
DR CCDS; CCDS53161.1; -. [Q9D9R7-1]
DR CCDS; CCDS53162.1; -. [Q9D9R7-2]
DR RefSeq; NP_001033705.2; NM_001038616.2. [Q9D9R7-1]
DR RefSeq; NP_081867.1; NM_027591.3. [Q9D9R7-3]
DR RefSeq; NP_083654.1; NM_029378.2. [Q9D9R7-2]
DR AlphaFoldDB; Q9D9R7; -.
DR STRING; 10090.ENSMUSP00000033686; -.
DR PRIDE; Q9D9R7; -.
DR ProteomicsDB; 279789; -. [Q9D9R7-3]
DR DNASU; 70887; -.
DR Ensembl; ENSMUST00000033686; ENSMUSP00000033686; ENSMUSG00000031323. [Q9D9R7-3]
DR Ensembl; ENSMUST00000120808; ENSMUSP00000112572; ENSMUSG00000031323. [Q9D9R7-2]
DR Ensembl; ENSMUST00000121197; ENSMUSP00000113569; ENSMUSG00000031323. [Q9D9R7-1]
DR GeneID; 70887; -.
DR KEGG; mmu:70887; -.
DR UCSC; uc009tzc.2; mouse. [Q9D9R7-2]
DR UCSC; uc009tze.2; mouse. [Q9D9R7-1]
DR CTD; 70887; -.
DR MGI; MGI:1918137; Dmrtc1a.
DR VEuPathDB; HostDB:ENSMUSG00000031323; -.
DR eggNOG; KOG3815; Eukaryota.
DR GeneTree; ENSGT00940000156489; -.
DR HOGENOM; CLU_050863_3_0_1; -.
DR InParanoid; Q9D9R7; -.
DR OrthoDB; 1429868at2759; -.
DR TreeFam; TF340713; -.
DR BioGRID-ORCS; 70887; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q9D9R7; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9D9R7; protein.
DR Bgee; ENSMUSG00000031323; Expressed in placenta labyrinth and 91 other tissues.
DR ExpressionAtlas; Q9D9R7; baseline and differential.
DR Genevisible; Q9D9R7; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR026607; DMRT.
DR InterPro; IPR031577; DMRT-C1/C2_C.
DR PANTHER; PTHR12322; PTHR12322; 1.
DR Pfam; PF15791; DMRT-like; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..182
FT /note="Doublesex- and mab-3-related transcription factor
FT C1"
FT /id="PRO_0000244103"
FT REGION 26..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..16
FT /note="MVEEEVAKKYDSSFTA -> MQRSSGSREPRKDFSPVTTSKKEEATPLKRRL
FT VERHKRTMAAAHPSHMHVKKLAVEEGVRT (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072,
FT ECO:0000303|PubMed:16488114"
FT /id="VSP_019522"
FT VAR_SEQ 146..156
FT /note="GTAGERGLQLA -> VKRELSGASRM (in isoform 2 and isoform
FT 3)"
FT /evidence="ECO:0000303|PubMed:16141072,
FT ECO:0000303|PubMed:16488114"
FT /id="VSP_019523"
FT VAR_SEQ 157..182
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072,
FT ECO:0000303|PubMed:16488114"
FT /id="VSP_019524"
FT CONFLICT 43
FT /note="L -> M (in Ref. 1; ABC48234 and 2; BAB24647)"
FT /evidence="ECO:0000305"
FT MOD_RES Q9D9R7-3:15
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 182 AA; 19230 MW; 0A17457204D2B142 CRC64;
MVEEEVAKKY DSSFTAGKNT VQQIQAQVDT ATQEESSQGP VLLNQHPETT SVPYTPETVG
QQLMVSLPGE PHGTSAMPSM CPSLILQPCA TTDPMLLQPQ VMGPSASNQA SVSATLEWQE
MLEAAEALLA LKNSSQTRHQ PCGMPGTAGE RGLQLANPSM PPRPTSSGSL PSGHLDCMSL
LT
