ID   DMD5_CAEEL              Reviewed;         280 AA.
AC   Q19291;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 2.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Doublesex- and mab-3-related transcription factor dmd-5 {ECO:0000303|PubMed:27144354};
GN   Name=dmd-5 {ECO:0000312|WormBase:F10C1.5};
GN   ORFNames=F10C1.5 {ECO:0000312|WormBase:F10C1.5};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, TISSUE SPECIFICITY, AND MUTAGENESIS OF TRP-54.
RX   PubMed=27144354; DOI=10.1038/nature17977;
RA   Oren-Suissa M., Bayer E.A., Hobert O.;
RT   "Sex-specific pruning of neuronal synapses in Caenorhabditis elegans.";
RL   Nature 533:206-211(2016).
CC   -!- FUNCTION: Transcription factor (By similarity). Required for sex-
CC       specific synaptic pruning, probably acting downstream of sex-
CC       determining transformer protein tra-1 (PubMed:27144354).
CC       {ECO:0000250|UniProtKB:Q9QZ59, ECO:0000269|PubMed:27144354}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC   -!- TISSUE SPECIFICITY: Dimorphically expressed in the dimorphically
CC       connected interneuron AVG; expression is observed in the AVG in males,
CC       but not in hermaphrodites. {ECO:0000269|PubMed:27144354}.
CC   -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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DR   EMBL; BX284602; CCD65032.1; -; Genomic_DNA.
DR   PIR; T16020; T16020.
DR   RefSeq; NP_495138.2; NM_062737.6.
DR   AlphaFoldDB; Q19291; -.
DR   SMR; Q19291; -.
DR   IntAct; Q19291; 5.
DR   STRING; 6239.F10C1.5; -.
DR   EPD; Q19291; -.
DR   PaxDb; Q19291; -.
DR   EnsemblMetazoa; F10C1.5.1; F10C1.5.1; WBGene00017326.
DR   GeneID; 184287; -.
DR   KEGG; cel:CELE_F10C1.5; -.
DR   UCSC; F10C1.5; c. elegans.
DR   CTD; 184287; -.
DR   WormBase; F10C1.5; CE29753; WBGene00017326; dmd-5.
DR   eggNOG; KOG3815; Eukaryota.
DR   GeneTree; ENSGT00940000168442; -.
DR   HOGENOM; CLU_967212_0_0_1; -.
DR   InParanoid; Q19291; -.
DR   OMA; QTAPLDC; -.
DR   OrthoDB; 1430043at2759; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00017326; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007548; P:sex differentiation; IBA:GO_Central.
DR   Gene3D; 4.10.1040.10; -; 1.
DR   InterPro; IPR001275; DM_DNA-bd.
DR   InterPro; IPR036407; DM_DNA-bd_sf.
DR   InterPro; IPR026607; DMRT.
DR   PANTHER; PTHR12322; PTHR12322; 1.
DR   Pfam; PF00751; DM; 1.
DR   SMART; SM00301; DM; 1.
DR   SUPFAM; SSF82927; SSF82927; 1.
DR   PROSITE; PS40000; DM_1; 1.
DR   PROSITE; PS50809; DM_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..280
FT                   /note="Doublesex- and mab-3-related transcription factor
FT                   dmd-5"
FT                   /id="PRO_0000455666"
FT   DNA_BIND        33..80
FT                   /note="DM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT   REGION          116..182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..182
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         54
FT                   /note="W->R: In gk408945; alterations in AVG interneuron
FT                   synaptic wiring. Suppresses the ectopic synapses formed
FT                   between PHB and AVG neurons when AVG is masculinized by
FT                   cell-specific expression of fem-3 in hermaphrodites.
FT                   Defects in male mating behavior; reduced efficiency in
FT                   locating vulva of partner."
FT                   /evidence="ECO:0000269|PubMed:27144354"
SQ   SEQUENCE   280 AA;  30849 MW;  1E9A10881E9C460F CRC64;
     MPVSPSSVSV LPPTSLEQIL RIRAERNQRT PKCARCRNHG TTSALKGHKR YCQWKDCMCA
     KCTLIAERQR VMAAQVALRR QQSQEERDAR DLEVLLGSAG NANDLLDILR LDAGEHHGKN
     HASPTTNNNN NTEEKYEDSQ GQRSSPSSPT GSETVVSTSS PPELSSESTP NTSGSVIPTS
     PVFKPNGYSS MPMFNPVYGR PFMRFPMFSV MPHFFGTPSM SDFASAASLA APPAFFSAQP
     TIATSSPSTI FPQTAPLDYS HRLMKNEEAE EEYRENDKTF