DMBX1_CHICK
ID DMBX1_CHICK Reviewed; 367 AA.
AC F1NEA7; Q8UVD8;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2013, sequence version 2.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Diencephalon/mesencephalon homeobox protein 1 {ECO:0000250|UniProtKB:Q8NFW5};
GN Name=DMBX1 {ECO:0000250|UniProtKB:Q8NFW5};
GN Synonyms=ATX {ECO:0000303|PubMed:11731459};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000312|Proteomes:UP000000539};
RN [1] {ECO:0000312|Proteomes:UP000000539}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Red jungle fowl {ECO:0000312|Proteomes:UP000000539};
RX PubMed=15592404; DOI=10.1038/nature03154;
RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA Wilson R.K.;
RT "Sequence and comparative analysis of the chicken genome provide unique
RT perspectives on vertebrate evolution.";
RL Nature 432:695-716(2004).
RN [2] {ECO:0000312|EMBL:AAL66342.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 5-306, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=12175514; DOI=10.1016/s0925-4773(02)00067-9;
RA Gogoi R.N., Schubert F.R., Martinez-Barbera J.-P., Acampora D., Simeone A.,
RA Lumsden A.;
RT "The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum.";
RL Mech. Dev. 114:213-217(2002).
RN [3] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=11731459; DOI=10.1242/dev.128.23.4789;
RA Martinez-Barbera J.P., Signore M., Boyl P.P., Puelles E., Acampora D.,
RA Gogoi R., Schubert F., Lumsden A., Simeone A.;
RT "Regionalisation of anterior neuroectoderm and its competence in responding
RT to forebrain and midbrain inducing activities depend on mutual antagonism
RT between OTX2 and GBX2.";
RL Development 128:4789-4800(2001).
CC -!- FUNCTION: Functions as a transcriptional repressor. Required for brain
CC development. {ECO:0000250|UniProtKB:Q91ZK4}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q91ZK4}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: In the embryo, expressed in the developing central
CC nervous system and in other tissues including the developing digestive
CC system (PubMed:12175514). At 9.7 dpc, expression is restricted to the
CC midbrain and pretectum (PubMed:11731459). {ECO:0000269|PubMed:11731459,
CC ECO:0000269|PubMed:12175514}.
CC -!- DEVELOPMENTAL STAGE: Expression detected from HH stage 4.
CC {ECO:0000269|PubMed:12175514}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR EMBL; AADN03005565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN03005656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF461038; AAL66342.1; -; mRNA.
DR AlphaFoldDB; F1NEA7; -.
DR SMR; F1NEA7; -.
DR STRING; 9031.ENSGALP00000032474; -.
DR PaxDb; F1NEA7; -.
DR Ensembl; ENSGALT00000033114; ENSGALP00000032474; ENSGALG00000010436.
DR VEuPathDB; HostDB:geneid_395271; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000155505; -.
DR HOGENOM; CLU_060969_0_0_1; -.
DR InParanoid; F1NEA7; -.
DR OMA; NSLNAMY; -.
DR TreeFam; TF351609; -.
DR PRO; PR:F1NEA7; -.
DR Proteomes; UP000000539; Chromosome 8.
DR ExpressionAtlas; F1NEA7; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Repressor; Transcription; Transcription regulation.
FT CHAIN 1..367
FT /note="Diencephalon/mesencephalon homeobox protein 1"
FT /id="PRO_0000434509"
FT DNA_BIND 71..130
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 129..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 344..357
FT /note="OAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT COMPBIAS 131..152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 302..305
FT /note="NMAP -> QHWR (in Ref. 2; AAL66342)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 367 AA; 41001 MW; 827C815389DB05BB CRC64;
MQHYGVNGYS LHAMNSLSAM YNLHQQAAQQ AQHAPDYRPS VHALTLAERL AGCTFQDIIL
EARYGSQHRK QRRSRTAFTA QQLEALEKTF QKTHYPDVVM RERLAMCTNL PEARVQVWFK
NRRAKFRKKQ RSLQKEQLQK QKDCESSHSE GKTEPPVLET QSTIPDTEKT QSIPSEVSTD
LNLTLSEQSA SESAPEDQTD REEEFKSTLD EAKVDKSPGV DGKALNCKRA SPKSESPISA
TVTPSSSSGL AQTHSYSSSP LSLFRLQEQF RQHMAATNNL VHYSSFEMGT PSAMPYLGMN
VNMAPLSSLH CQSYYQSLSH AQQVWSSPIL QASSSLPSLN SKTTSIENLR LRAKQHAASL
GLDTLPN
