DMBTL_MOUSE
ID DMBTL_MOUSE Reviewed; 841 AA.
AC Q8BZE1; E9QN00;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Putative DMBT1-like protein;
DE Flags: Precursor;
GN Name=Cdcp3 {ECO:0000312|MGI:MGI:1918645};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Urinary bladder;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SIMILARITY: Belongs to the DMBT1 family. {ECO:0000305}.
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DR EMBL; AK035662; BAC29143.1; -; mRNA.
DR EMBL; AC110885; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS21911.1; -.
DR RefSeq; NP_780375.2; NM_175166.3.
DR AlphaFoldDB; Q8BZE1; -.
DR SMR; Q8BZE1; -.
DR STRING; 10090.ENSMUSP00000061529; -.
DR GlyGen; Q8BZE1; 1 site.
DR PaxDb; Q8BZE1; -.
DR PRIDE; Q8BZE1; -.
DR DNASU; 71395; -.
DR Ensembl; ENSMUST00000050586; ENSMUSP00000061529; ENSMUSG00000006204.
DR GeneID; 71395; -.
DR KEGG; mmu:71395; -.
DR UCSC; uc009kba.1; mouse.
DR CTD; 71395; -.
DR MGI; MGI:1918645; Cdcp3.
DR VEuPathDB; HostDB:ENSMUSG00000006204; -.
DR eggNOG; ENOG502QQ5W; Eukaryota.
DR GeneTree; ENSGT00940000162108; -.
DR HOGENOM; CLU_002555_11_3_1; -.
DR InParanoid; Q8BZE1; -.
DR OrthoDB; 1095487at2759; -.
DR PhylomeDB; Q8BZE1; -.
DR TreeFam; TF329295; -.
DR BioGRID-ORCS; 71395; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8BZE1; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BZE1; protein.
DR Bgee; ENSMUSG00000006204; Expressed in olfactory epithelium and 33 other tissues.
DR ExpressionAtlas; Q8BZE1; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR CDD; cd00041; CUB; 3.
DR Gene3D; 2.60.120.290; -; 3.
DR Gene3D; 3.10.250.10; -; 3.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR Pfam; PF00431; CUB; 3.
DR Pfam; PF00530; SRCR; 3.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00202; SR; 3.
DR SUPFAM; SSF49854; SSF49854; 3.
DR SUPFAM; SSF56487; SSF56487; 3.
DR PROSITE; PS01180; CUB; 3.
DR PROSITE; PS00420; SRCR_1; 1.
DR PROSITE; PS50287; SRCR_2; 3.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Repeat; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..841
FT /note="Putative DMBT1-like protein"
FT /id="PRO_0000343686"
FT DOMAIN 144..244
FT /note="SRCR 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 272..378
FT /note="CUB 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 428..528
FT /note="SRCR 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 556..667
FT /note="CUB 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 680..780
FT /note="SRCR 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 795..841
FT /note="CUB 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT REGION 32..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..548
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 294
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 169..233
FT /evidence="ECO:0000250"
FT DISULFID 182..243
FT /evidence="ECO:0000250"
FT DISULFID 213..223
FT /evidence="ECO:0000250"
FT DISULFID 272..297
FT /evidence="ECO:0000250"
FT DISULFID 320..342
FT /evidence="ECO:0000250"
FT DISULFID 453..517
FT /evidence="ECO:0000250"
FT DISULFID 466..527
FT /evidence="ECO:0000250"
FT DISULFID 497..507
FT /evidence="ECO:0000250"
FT DISULFID 556..582
FT /evidence="ECO:0000250"
FT DISULFID 609..631
FT /evidence="ECO:0000250"
FT DISULFID 705..769
FT /evidence="ECO:0000250"
FT DISULFID 718..779
FT /evidence="ECO:0000250"
FT DISULFID 749..759
FT /evidence="ECO:0000250"
FT DISULFID 795..821
FT /evidence="ECO:0000250"
FT CONFLICT 672
FT /note="R -> I (in Ref. 1; BAC29143)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 841 AA; 90689 MW; A39C7BB2F53E89D0 CRC64;
MGCHTRLLWL LFFHAAILPE AACYRRDFRG SGARLGKERP KRSSIQGVSE EQQEGHGEEP
AARPQGDGNP ATILSVLPAA ISTQPSSKLA PSSSVSVLPV ADSAPGSRRA HAPRINLKGA
DMLPDLTPVI DPESYKPSGG WAPVRLAGNH GSCAGRVELF YQGVWGTVCD DLWDLPQANI
ICRQLGCGWA VSALSEAYFG QGSGKILLDN VHCKGHEEHL EECSHLGWFS HNCDHSEDAS
VICSDAEYGT VTLSDPPLAA MEGATNPEKS RCGGVITSAP GKIKNPPMNE MHDNITCVWE
IRASTSEHIR LAFPSLDLDC TNEYFEILDG PPSSTKSLGK PCRGLHITFA SHSSSMTLVY
FRGENNIGKN FMAYYYFEAK EMTTKTPYLI TIPTATSKMV TERPQFSNTP SGNISPLPVS
DSGDWPELRL VGGSSRCSGR VEILYQGVWG TICDDLWGSN EAEVVCRQLE CGQAVSSLGE
AYFGPGSGEI FLDNLQCSGM EHYLGQCPHS GWSEHNCGHH EDAGVICSDS DAPPPPMPPG
PPPTPQDPLT GGSNSCGGVI SSLSGSFTSP RYPENYPTDI QCVWEIHVEK NFRIELMIPN
LNLEDILGCP YDSIEIFDGP RIASLSMGKF CAPSAVVFFS SSDILTVVFR SDYMTTNTGF
YAFFNAIPQD GRESEERPVL RLAGSSGQCS GRVEILHQGA WGTVCDDLWD LNEAEVVCRQ
LGCGHAIAAP GSAYFGPGSG NILLDNIQCS GTENHFGQCS SSAWLDHNCG HHEDAGVICS
DADVTPSPTE GSHSCGGVIS NLSGSFSSPW YPTNYPTDTE CIWEIHVAEK FNIELTIPSL
K
