ID   DLTS_STRA5              Reviewed;         395 AA.
AC   Q8DXQ8;
DT   23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Sensor protein DltS;
DE            EC=2.7.13.3;
GN   Name=dltS; OrderedLocusNames=SAG1791;
OS   Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=208435;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-611 / 2603 V/R;
RX   PubMed=12200547; DOI=10.1073/pnas.182380799;
RA   Tettelin H., Masignani V., Cieslewicz M.J., Eisen J.A., Peterson S.N.,
RA   Wessels M.R., Paulsen I.T., Nelson K.E., Margarit I., Read T.D.,
RA   Madoff L.C., Wolf A.M., Beanan M.J., Brinkac L.M., Daugherty S.C.,
RA   DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Lewis M.R., Radune D.,
RA   Fedorova N.B., Scanlan D., Khouri H.M., Mulligan S., Carty H.A.,
RA   Cline R.T., Van Aken S.E., Gill J., Scarselli M., Mora M., Iacobini E.T.,
RA   Brettoni C., Galli G., Mariani M., Vegni F., Maione D., Rinaudo D.,
RA   Rappuoli R., Telford J.L., Kasper D.L., Grandi G., Fraser C.M.;
RT   "Complete genome sequence and comparative genomic analysis of an emerging
RT   human pathogen, serotype V Streptococcus agalactiae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:12391-12396(2002).
CC   -!- FUNCTION: Member of the two-component regulatory system DltS/DltR.
CC       Regulates the expression of the dlt operon. Probably phosphorylates
CC       DltR (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AE009948; AAN00654.1; -; Genomic_DNA.
DR   RefSeq; NP_688781.1; NC_004116.1.
DR   RefSeq; WP_000490535.1; NC_004116.1.
DR   AlphaFoldDB; Q8DXQ8; -.
DR   SMR; Q8DXQ8; -.
DR   STRING; 208435.SAG1791; -.
DR   EnsemblBacteria; AAN00654; AAN00654; SAG1791.
DR   GeneID; 66886630; -.
DR   KEGG; sag:SAG1791; -.
DR   PATRIC; fig|208435.3.peg.1799; -.
DR   HOGENOM; CLU_000445_89_6_9; -.
DR   OMA; KFVLINM; -.
DR   Proteomes; UP000000821; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Kinase; Membrane; Nucleotide-binding;
KW   Phosphoprotein; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix; Two-component regulatory system.
FT   CHAIN           1..395
FT                   /note="Sensor protein DltS"
FT                   /id="PRO_0000074731"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          177..387
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT   MOD_RES         180
FT                   /note="Phosphohistidine; by autocatalysis"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
SQ   SEQUENCE   395 AA;  45764 MW;  6FEDFE55E5A2CC15 CRC64;
     MFSDLRKKFV FLTMSILIVV VLFLFAVSNR YNQYWDEYDA YRIVKLVAKN DYLGIPGDEP
     IALVTIDNQK MVKIQSNNTD LTNDVIEKSS LKLLEQGKKS RKWKSFIYSI KEYKDKTYTI
     AIMDLASYEV PYARRFLILV FTIFGFCLLA AVSLYLSRFI VGPVETEMTR EKQFVSDASH
     ELKTPIAAIR ANVQVLEQQI PGNRYLDHVV SETKRMEFLI EDLLNLSRLD EKRSKVNFKK
     LNLSVLCQEV LLTYESLAYE EEKCLNDTIE DDVWIVGEES QIKQILIILL DNAIRHSLSK
     SAIQFSLKQA RRKAILTISN PSAIYSKEVM DNLFERFYQA KDDHADSLSF GLGLSIAKAI
     VERHKGRIRA YQEKDQLRLE VQLPIDGFWT NTMIN