ID   DJC22_BOVIN             Reviewed;         347 AA.
AC   Q17QW0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=DnaJ homolog subfamily C member 22;
GN   Name=DNAJC22;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a co-chaperone.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q17QW0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q17QW0-2; Sequence=VSP_032459, VSP_032460;
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DR   EMBL; AAFC03102965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC118149; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; NP_001069169.2; NM_001075701.2. [Q17QW0-1]
DR   AlphaFoldDB; Q17QW0; -.
DR   SMR; Q17QW0; -.
DR   STRING; 9913.ENSBTAP00000055590; -.
DR   PaxDb; Q17QW0; -.
DR   PRIDE; Q17QW0; -.
DR   Ensembl; ENSBTAT00000063126; ENSBTAP00000055590; ENSBTAG00000016398. [Q17QW0-1]
DR   GeneID; 515215; -.
DR   KEGG; bta:515215; -.
DR   CTD; 79962; -.
DR   VEuPathDB; HostDB:ENSBTAG00000016398; -.
DR   eggNOG; KOG0714; Eukaryota.
DR   GeneTree; ENSGT00390000012136; -.
DR   HOGENOM; CLU_057927_1_0_1; -.
DR   InParanoid; Q17QW0; -.
DR   OMA; LASAWWT; -.
DR   OrthoDB; 1058581at2759; -.
DR   TreeFam; TF324581; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000016398; Expressed in caput epididymis and 40 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR036869; J_dom_sf.
DR   InterPro; IPR007829; TM2.
DR   Pfam; PF00226; DnaJ; 1.
DR   Pfam; PF05154; TM2; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Chaperone; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..347
FT                   /note="DnaJ homolog subfamily C member 22"
FT                   /id="PRO_0000325861"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          277..347
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT   VAR_SEQ         282..297
FT                   /note="FGLSEGATNEEIHGRY -> RFLPSHCCLRWLQKLD (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_032459"
FT   VAR_SEQ         298..347
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_032460"
SQ   SEQUENCE   347 AA;  39014 MW;  CCF95FAC117ABB94 CRC64;
     MAKGLLMTYT LWAVGGPAGL HHLYLGRDSH ALLWMLTLGG GGLGWLWEFW MLPSFVAQAN
     RAQEQRQGSG RGTPPLSLIR FVAQMIVGMY FGLVALISLS FMASFYIVGL PLAVGLGVLL
     VAAVGNQTSD LKNTLGAAFL TSPIFYGRPI AILPISLAAS ITAQKHRRYK PSVGSETLSV
     RLYRLGLAYL AFTGPLVHSV LCHTAVTLSY VADTLGSFLS WFSFFPLLGR LLESVLLLPF
     RAWKLLVGDH GISSSYFQEW EKLYEFVHSF QDEKRQLALQ VFGLSEGATN EEIHGRYREL
     VKTWHPDHNR YQMEEAQRRF LEIQAAYEVL RQPRKPRGSW RWEETSF