ID   DIRK1_BUTOC             Reviewed;          14 AA.
AC   P0DQU9;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-AUG-2022, sequence version 1.
DT   03-AUG-2022, entry version 1.
DE   RecName: Full=RK1 peptide {ECO:0000303|PubMed:29366787};
DE   AltName: Full=Disintegrin-like peptide;
OS   Buthus occitanus tunetanus (Common European scorpion) (Buthus tunetanus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Buthus.
OX   NCBI_TaxID=6871;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SYNTHESIS, SUBCELLULAR LOCATION, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=29366787; DOI=10.1016/j.bbrc.2018.01.133;
RA   Khamessi O., Ben Mabrouk H., ElFessi-Magouri R., Kharrat R.;
RT   "RK1, the first very short peptide from Buthus occitanus tunetanus inhibits
RT   tumor cell migration, proliferation and angiogenesis.";
RL   Biochem. Biophys. Res. Commun. 499:1-7(2018).
CC   -!- FUNCTION: Venom peptide with no toxicity on mice (ICV injection) and
CC       tumor cell lines (PubMed:29366787). Inhibits cell proliferation,
CC       migration and angiogenesis of glioma and melanoma tumor cell lines
CC       (PubMed:29366787). May act by binding to integrins (Probable).
CC       {ECO:0000269|PubMed:29366787, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29366787}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:29366787}.
CC   -!- MASS SPECTROMETRY: Mass=1467.67; Method=MALDI; Note=Average mass.;
CC       Evidence={ECO:0000269|PubMed:29366787};
CC   -!- SIMILARITY: Belongs to the disintegrin-like family. {ECO:0000305}.
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PE   1: Evidence at protein level;
KW   Cell adhesion impairing toxin; Direct protein sequencing; Disulfide bond;
KW   Secreted; Toxin.
FT   PEPTIDE         1..14
FT                   /note="RK1 peptide"
FT                   /evidence="ECO:0000269|PubMed:29366787"
FT                   /id="PRO_0000455819"
FT   DISULFID        3..12
FT                   /evidence="ECO:0000305|PubMed:29366787"
SQ   SEQUENCE   14 AA;  1470 MW;  01735F36C6CF8A24 CRC64;
     IDCSKVNLTA ECSS